DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdx1 and Scr

DIOPT Version :9

Sequence 1:	NP_074043.4	Gene:	Pdx1 / 29535	RGDID:	62387	Length:	283	Species:	Rattus norvegicus
Sequence 2:	NP_001368995.1	Gene:	Scr / 40833	FlyBaseID:	FBgn0003339	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	315	Identity:	98/315 - (31%)
Similarity:	123/315 - (39%)	Gaps:	107/315 - (33%)

- Green bases have known domain annotations that are detailed below.

  Rat    61 SPPDISPYEVPP-----------------------LADDPAGAHLHHHL--------PAQLGL-A 93
            ||.|:|..::.|                       ||...|.|.|:::.        |..:.: .
  Fly   206 SPQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPM 270

  Rat    94 HPPPG-----PFPNGTETG-------GLEEPSRVHLPFPWMKSTKAHAWKSQW-AGGAYAAEPEE 145
            |.|.|     ...:|.|.|       |.:.|.::   :||||  :.|...|.. |.|       |
  Fly   271 HSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQI---YPWMK--RVHLGTSTVNANG-------E 323

  Rat   146 NKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRS 210
            .||.||:|||.|.|||||||.||:|::|.||:|:|..|.||||.|||||||||||||||. |..|
  Fly   324 TKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEH-KMAS 387

  Rat   211 SGTT--------------------------------SGGGGG-----EEPEQDCAVTSGEE-LLA 237
            ....                                ||.|..     :||.|..|..|... ..:
  Fly   388 MNIVPYHMGPYGHPYHQFDIHPSQFAHLSAXDAWHFSGTGXRLNQLYQEPYQTAAAASAASGYQS 452

  Rat   238 LPPPPPPGGAV--------PSGVPAAAREGRLPSGLSASPQPSSIAP---LRPQE 281
            ....|..||:|        |..:......|..|:.|.||...||.||   ..|||
  Fly   453 QDGGPIGGGSVGVGGGAGGPGSLANGGSNGSGPNSLFASAASSSQAPDCIKYPQE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdx1	NP_074043.4	Transactivation domain	13..73		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..81		8/42 (19%)
		Antp-type hexapeptide	118..123		2/4 (50%)
		Homeobox	149..203	CDD:395001	38/53 (72%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..283		31/130 (24%)
Scr	NP_001368995.1	Homeobox	328..381	CDD:395001	38/52 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810