DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptgs2 and cysu

DIOPT Version :9

Sequence 1:	NP_058928.3	Gene:	Ptgs2 / 29527	RGDID:	620349	Length:	604	Species:	Rattus norvegicus
Sequence 2:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster

Alignment Length:	748	Identity:	145/748 - (19%)
Similarity:	241/748 - (32%)	Gaps:	252/748 - (33%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MLFRAVLLCAALALSHAANPCCSNPCQNRGECMSIGFDQYKCDCTRTGFYGENCTTPEFLTRIKL 65
            |:.|.:||..| |::||                     ||.       .:||...|........|
  Fly     1 MILRILLLSLA-AVAHA---------------------QYH-------QFGEQLQTAHGSDCALL 36

  Rat    66 LLKPTPNTVH-YILTHFKGVWNIVNNIP---FLRNSIMRYVLTSRSHLIDSPP------------ 114
            |..|..::|: |.:..|:|..|..||.|   ...::|....|.:|..:..:.|
  Fly    37 LAGPGRSSVYDYNVNLFRGTLNPYNNGPGTCITYDAINAAYLDARKRIHVAQPKSDWKPEELATV 101

  Rat   115 -------------TYNVHY---------------------------------GYKSWEAF-SNLS 132
                         ||.:.|                                 .|:.::.. :|:.
  Fly   102 GELLLDISIQLARTYGLSYEEIEKGLPTIDTSKTLIREVCPPFFAGVECRPGKYRRFDGLCNNIE 166

  Rat   133 Y---------YTRALPPV-ADDCPTP-MGVKGNKELPDSKEVLEKVLLRREFIPDPQGTNMMFAF 186
            :         :.|.:.|: :|....| :.|.| ::||.|: |:.:.:...:...|..||.|:.|
  Fly   167 HPTWGAANAPFQRLIGPLYSDGINAPRISVTG-RDLPFSR-VVSRTMHPDDGFHDHAGTVMVIA- 228

  Rat   187 FAQHFTHQFFKTDQKRGP-----------------------------------------GFTRG- 209
            :.|...|.|..|.....|                                         .|.||
  Fly   229 WGQFMDHDFTLTGTPLDPINRNDPEECCKRPLHLKHPYCNEIRIPDDDYFYRLFNVKCIDFVRGF 293

  Rat   210 --------LGHG---------VDLNHVYGETLDRQHKLRLFQDGKLKYQVIGGEVYPPTVKDTQV 257
                    ||..         :|.|.|||.......|||....|.::..        |..::..:
  Fly   294 PSPRPGCKLGSRQQFNTLTGVIDANTVYGVKESFARKLRTGYGGLMRMN--------PVFQEYGL 350

  Rat   258 DMIYPPHVPEHLRFAVGQEVFGLV-PGLMMYA------------------TIWLREHNRVCDILK 303
            ..:.|      |:..:..|  |.. |...||.                  |:..|||||:...|.
  Fly   351 KDLLP------LKLDIPDE--GCTRPNKSMYCFEGGEIRVNEQLVLTCMHTLMAREHNRLATALA 407

  Rat   304 QEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFN 368
            |.:..||||.|||.:|.|.|.....:...:::..|.|.....||.   |..|:..|.:...|..|
  Fly   408 QINKHWDDETLFQEARRINIAIVQHVTFNEFLPILLGKEVMEKFG---LVLQKDGYWDGYDSTVN 469

  Rat   369 ----------TLYHWHPLLPDTFNIEDQEYTF---KQF---------LYNNSILLEH--GLAHFV 409
                      .....|.|||.......:.:.|   |:.         ||...:|.|:  ||.:.|
  Fly   470 PGIIDSFAGAAFRFGHSLLPTAVERWSKAHKFIASKRLSDLIRRPYDLYRAGVLDEYFMGLMNQV 534

  Rat   410 -----ESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTG 469
                 :|.|:::...:.........:..|: .::.:.||.......|:||...|....:::|:.|
  Fly   535 AQAMDDSITQEVTNHLFKKEGARFGMDLVS-FNMQRGREFGIPGYMEFRKFCGLPTSNTWDEMYG 598

  Rat   470 E--KEMAAELKALYHDIDAMELYPALLVEKPRPDAIFGET---MVELGAPFSLKGLMGNPICSPQ 529
            .  .|......:::.....::|:...:.||..|.::.|.|   ::.....:..:|        .:
  Fly   599 SMPNETVLRYGSIFEHPADIDLWSGGVSEKSLPGSMLGPTFACVIATQMSYLRRG--------DR 655

  Rat   530 YW-----KPSTFGGEVGFRIINTASIQSLICNN 557
            :|     :||:|..| ..:.|..|.:..|||:|
  Fly   656 FWYELPNQPSSFTPE-QLQEIRKAKLSRLICDN 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptgs2	NP_058928.3	EGF	21..53	CDD:278437	3/31 (10%)
Ptgs2	NP_058928.3	prostaglandin_endoperoxide_synthase	75..562	CDD:188648	128/674 (19%)
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	114/565 (20%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	86/410 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810