DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc22a6 and Orct

DIOPT Version :9

Sequence 1:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus
Sequence 2:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	168/557 - (30%)
Similarity:	285/557 - (51%)	Gaps:	21/557 - (3%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRPPANANLSKDGGLEA 65
            |.::|::..:|..|.:|.....::..|.::.|.|.....|..|.|...|..|     .::|.:..
  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALP-----YENGSIYE 60

  Rat    66 WLP-LDKQGQPES--CLRFTSPQWGPPFYNGTEANGTRVTEPCIDGWVYDNSTFPSTIVTEWNLV 127
            ..| |.....||:  | .:....:...:.||:....:..|:.| ..:|||.|.:.::.|||||||
  Fly    61 LSPHLWNLSYPENERC-SYYDVDYTEEYLNGSIPRSSNETKTC-SSYVYDRSKYLNSAVTEWNLV 123

  Rat   128 CSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVFR 192
            ||.......:.||:|:|||||:::||.::|:|||:.....:.:...:.|..||.||.|..|.:.|
  Fly   124 CSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISR 188

  Rat   193 LLSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVP 257
            ::.|.:.:.:.:....:.:|.:....|.:.|..:...:|:|..|.||.||.:..||.||:.:::|
  Fly   189 MIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLP 253

  Rat   258 FFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQ---EEGAKLSIEVLRTSLQKELTL 319
            ..:...|.|...|||||....||.|.....:::.|:.|..:   |...:|..||.....|.|:..
  Fly   254 GLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAA 318

  Rat   320 SKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFV 384
            |:..|:..:|||.|.||...|.:...||..|..||||..:....|.:..:..:|.|||::|...:
  Fly   319 SQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTL 383

  Rat   385 CFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHTIIRTSLAVLGKGCLASSFNCIFLYTGELY 449
            ....:|..|||.....::::|||.:|....:|.....:..:.|::||..:.||:..|::::.|.:
  Fly   384 LLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQF 448

  Rat   450 PTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLGQPLPD 514
            |||:|..|||..|.:||||.|::|.:.:..|.:..:||.|.||:.:.|..::.||||||.:|:|:
  Fly   449 PTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPE 513

  Rat   515 TVQDLKSRSRGKQNQQQQEQQKQMMPLQASTQEKNGL 551
            |::|  ..:.||:...|:..:      :..|||.:|:
  Fly   514 TIED--GENFGKKPAPQETAE------EGGTQELSGM 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	157/509 (31%)
		MFS	135..505	CDD:119392	116/372 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		8/36 (22%)
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	157/509 (31%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	112/355 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347128
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm9087
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.950