DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a6 and CG7458

DIOPT Version :9

Sequence 1:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus
Sequence 2:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	139/540 - (25%)
Similarity:	259/540 - (47%)	Gaps:	24/540 - (4%)

- Green bases have known domain annotations that are detailed below.

  Rat     6 LLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRPP---ANANLSKDGGLEAWL 67
            :|.::|..||:|:|...::..|:|..|..:....|||:...|.|..|   :.:::.::..|...:
  Fly    41 ILVRIGQFGRYQIINYVLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWLGFTI 105

  Rat    68 PLDKQGQPESCLRFTSPQWGPPFYNGTEANG--------TRVTEPCIDGWVYDNSTFPSTIVTEW 124
            | .|....:.|.|:.: .........|:.:|        |..:|.|  |..:.......||.||:
  Fly   106 P-KKNSAWDDCHRYAA-NISDAISGYTDPSGQYCLKEYFTITSETC--GRDFKFRDEEKTISTEF 166

  Rat   125 NLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYC 189
            .:.|.......:..::..||..:|..:.||.|||.|||.:|.:....:|:.|...:.:.||:::.
  Fly   167 GIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYSMFL 231

  Rat   190 VFRLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVV 254
            ||..|.....:::......|.:|.:....|....|:|...|:||:..|..:|..|.|||.|..|:
  Fly   232 VFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLASQVQHWRWLLRVL 296

  Rat   255 SVPFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTSLQKELTL 319
            ..|..:..::.|...||.||..|.|..:.....|:|.||||.:.....:|: ::|.::.||   |
  Fly   297 YAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPLPEEQLN-DLLTSNRQK---L 357

  Rat   320 SKGQASAMELLRCP---TLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPA 381
            |:...|...::|..   :||....||  .||..:....||.::....|.:.|...::.|.:.:|.
  Fly   358 SQANESQYPIMRAVVFFSLRIANCCL--CWFTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQIPG 420

  Rat   382 KFVCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHTIIRTSLAVLGKGCLASSFNCIFLYTG 446
            ..:..::::.:|||.:..||:||..||:..:..:|..:.....:|.::||..:..||..::.:|.
  Fly   421 LLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFLIGKLAITCSFQILYFFTS 485

  Rat   447 ELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLGQP 511
            |::||.:|.|.|.:.|.:.|:||:::|...:.|::|...|..:|....:::..:|...|||..:.
  Fly   486 EIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAFPETADKV 550

  Rat   512 LPDTVQDLKSRSRGKQNQQQ 531
            ||.|:::.:..::.|:..::
  Fly   551 LPTTIEEARDLNQAKRRSER 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	136/517 (26%)
		MFS	135..505	CDD:119392	101/372 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		2/18 (11%)
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	136/517 (26%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	106/388 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347391
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960