DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc22a6 and CG4630

DIOPT Version :9

Sequence 1:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus
Sequence 2:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	160/572 - (27%)
Similarity:	273/572 - (47%)	Gaps:	66/572 - (11%)

- Green bases have known domain annotations that are detailed below.

  Rat     3 FNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCR-PPANANLSKDGGLEAW 66
            |:|:|.::|..||||.....::..|:|..|:::....|||..|.:.|. |..:..:..:.|.. |
  Fly    15 FDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGAN-W 78

  Rat    67 LPL------DKQGQ--PESCLRF---------TSPQWGP-PFYNGTEANGTRVTEPCIDGWVYDN 113
            :.:      .|:|.  |.:|.||         :|..|.. |.......|.|..||.| :.:||.:
  Fly    79 VSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERC-NQFVYGS 142

  Rat   114 STFPSTIVTEWNLVCSHRAFR-QLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGT 177
            |  ..|||.:|.|.|....:: ....:::..|:::|..:.||||||.||:.:.:...:..|::|.
  Fly   143 S--ERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMALTGV 205

  Rat   178 CAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAY 242
            ..|.:.:|..:..|.||:.:..:.:......:.||.:....|.....::.|.|::|:.|| |::.
  Fly   206 AQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALL-GLSV 269

  Rat   243 AVPHWRHLQLVVSVPFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIE 307
            .:|.||.|||.:|||..|...|.|...||.||..:..|.:.....::|.|::|.:.     :|:|
  Fly   270 FLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRD-----ISVE 329

  Rat   308 VLRTSLQKELTLSKGQ-----------------ASAMELLRCPTLRHLFLCLSMLWFATSFAYYG 355
            ::.:..|:||....||                 .:..|:.|...|...:..|.::|...:..|||
  Fly   330 LMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIVYYG 394

  Rat   356 LVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSH- 419
            |.::......:.||...:...|::|...:.:|.:...|||.|...||||..|..:.:|.:..:.
  Fly   395 LSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQG 459

  Rat   420 ------------------TIIRTSLAVLGKGCLASSFNCIFLYTGELYPTVIRQTGLGMGSTMAR 466
                              ..:..:|.::||..:.|||..|:.:|.|:.|||||..|:|:.||.||
  Fly   460 DWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTFAR 524

  Rat   467 VGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLGQPLPDTVQD 518
            .|::::|.|.:.|.:|..:||.:||.:.:||..::.|||||..:.|||||::
  Fly   525 FGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEE 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	154/559 (28%)
		MFS	135..505	CDD:119392	109/405 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		3/5 (60%)
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	154/559 (28%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	99/380 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347395
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.960