DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a3 and CG6356

DIOPT Version :9

Sequence 1:	NP_062103.1	Gene:	Slc22a3 / 29504	RGDID:	3701	Length:	551	Species:	Rattus norvegicus
Sequence 2:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	144/567 - (25%)
Similarity:	238/567 - (41%)	Gaps:	87/567 - (15%)

- Green bases have known domain annotations that are detailed below.

  Rat     8 LRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPEE--- 69
            |...|..|.|...:|.|.....:...|.......||..||..||..|.    .:...|:..:
  Fly    28 LEVVGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPE----LQDTNWTHAQKRE 88

  Rat    70 --------------EWNL-TTPELHVPAERRGQGHCHRYLLEDTNTSSELSCDPLAAFPNRSAPL 119
                          :||. ...::...|.....||     |...:..:|:||
  Fly    89 IVAKGLDSGGCTVWDWNYGHLAKMSYEAALNYTGH-----LTQISPPAEVSC------------- 135

  Rat   120 VPCSGDWRYVETHSTIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIVYLISC 184
             ...|...:....:|.|:.:||.|..:......|..::||...|:|:.|..||::||.     |.
  Fly   136 -RVKGQHEFAHPETTFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRK-----SS 194

  Rat   185 FGVGITGVVV-----AFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMF 244
            |.:|....:|     .|:|.:|:|:..||..|....|.:...|.::.|.:..|.|..:.|.....
  Fly   195 FTLGAAFFIVGSFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSAS 259

  Rat   245 FTLGIIILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKC 309
            :.:|:|||..:.|....|:.:|||:::||.|.:|..:::.||||||||.::.::..:||.|
  Fly   260 YPVGMIILAIVGYVIQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFR---- 320

  Rat   310 NGKHLSSNY---------SEITVTDEEVSNP----------------SCLDLVRTPQMRKCTLIL 349
                ..|:|         |:: .:|::...|                |.::|....::|:.....
  Fly   321 ----QPSHYQIQPAVAAPSQV-ASDKKSLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFAS 380

  Rat   350 MFAWFTSAVVYQGLVMRLGLIGGNLYMDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGV 414
            .|.:..:::.|....:....:..:.|:....:|||::|..|:.::.:...||||......:..||
  Fly   381 YFMFCVTSLSYYVTALNAANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGV 445

  Rat   415 SCLVTAFLPEG-IPWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGII 478
            |.|:...:|.| ..|: ...|.|||.||:..:.:|.|..:|||||.:||..:..||.....|.|.
  Fly   446 SLLLVLAVPAGSTTWI-VAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSIS 509

  Rat   479 APFLLFRLAAIWLELPLIIFGILASVCGGLVMLLPETKGIALPETVE 525
            ||:::..|.|:...:|..|.|....|.|.|.:.||||....|.:.||
  Fly   510 APYVVDVLGALGWYIPTTICGCCVLVAGLLTLTLPETGTGKLSDKVE 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	141/559 (25%)
Slc22a3	NP_062103.1	MFS	145..513	CDD:119392	107/398 (27%)
CG6356	NP_651240.1	MFS	167..544	CDD:119392	107/391 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347273
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950