DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a2 and CG4630

DIOPT Version :9

Sequence 1:	NP_113772.1	Gene:	Slc22a2 / 29503	RGDID:	61936	Length:	593	Species:	Rattus norvegicus
Sequence 2:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	172/579 - (29%)
Similarity:	274/579 - (47%)	Gaps:	71/579 - (12%)

- Green bases have known domain annotations that are detailed below.

  Rat     5 DDILEHIGEFHLFQKQTFFLLALLSGAFTPIY------VGIVFLGFTPDHHCWSPGAAKL---SQ 60
            ||||..||||..||::.:.|:.|      |:.      :..||...:|.:.|:.|...||   ..
  Fly    16 DDILVEIGEFGRFQRRNYLLICL------PVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEY 74

  Rat    61 RCGWSQAEELNYTVPGLGPSDEASFL-SQCMRYEV--DWNQSTLD--CVDPLSSLAADRNQLPLG 120
            ...|     ::..||| ..|....|. |.|.|:..  |..:|:.|  ...||....|:.......
  Fly    75 GANW-----VSIAVPG-SWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETE 133

  Rat   121 PCEHGWVYNTPGSSIVTEFNLVCAHS-WMLDLFQSVVNVGFFIGAMMIGYLADRFGRKFCLLVTI 184
            .|.. :||.:...:||.::.|.|..: |.|....::...|..:|..:.||||||:|||...|..|
  Fly   134 RCNQ-FVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCI 197

  Rat   185 LINAISGALMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRMVGICYQIAFTVGL 249
            :..|::|...|:|.:|...|.|..|..:.:...:.:.:|:..|.||...|.|..|.....:.||.
  Fly   198 VFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGE 262

  Rat   250 LILAGVAYVIPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKIVKAMKIIKHIAKKNGKSV 314
            .:| |::..:|:||.||.|:::|....:.|||.:|||.|||:::|:..:|..||:..||.|.:.:
  Fly   263 ALL-GLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDI 326

  Rat   315 PVSL------QNLTPDEDAGK--------------KLKPSILDLVRTPQIRKHTLILMYNWFTSS 359
            .|.|      |.|  |.:.|:              |:..::.::.|:..:.....||:..|..::
  Fly   327 SVELMASFKQQEL--DAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNA 389

  Rat   360 VLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACLASVFI 424
            ::|.||.::......|.||:|....|||.|...:..|.:.|.|||...:.|.::....|:||.|:
  Fly   390 IVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFV 454

  Rat   425 P-------------------DDLQWLKITIACLGRMGITMAYEMVCLVNAELYPTYIRNLGVLVC 470
            .                   ....||.:|:..:|::|||.::.::....||:.||.||:.||.|.
  Fly   455 TLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVM 519

  Rat   471 SSMCDIGGIITPFLVYRLTDIWMEFPLVVFAVVGLVAGALVLLLPETKGKALPETIEDA 529
            |:....|.::.|| |..|...:...||::|..:.||||.|.||||||..:.||:|:|:|
  Fly   520 STFARFGAMLAPF-VPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEA 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a2	NP_113772.1	2A0119	12..525	CDD:273328	164/566 (29%)
Slc22a2	NP_113772.1	MFS	125..492	CDD:119392	117/406 (29%)
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	164/566 (29%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	109/378 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930