DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg4 and dlg1

DIOPT Version :9

Sequence 1:	NP_062567.1	Gene:	Dlg4 / 29495	RGDID:	68424	Length:	724	Species:	Rattus norvegicus
Sequence 2:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster

Alignment Length:	591	Identity:	279/591 - (47%)
Similarity:	363/591 - (61%)	Gaps:	108/591 - (18%)

- Green bases have known domain annotations that are detailed below.

  Rat    54 VNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSIL 118
            |||.:..: ||:|.||||||||||||||||||||||.|.||:|||:|.|||||.||||.:||.|:
  Fly   444 VNGDDSWL-YEDIQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIV 507

  Rat   119 FVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPA-------------------EKVMEIKLI 164
            .||:|.|.:|.|::||:|||:||::|:|:|.|::..|                   .||:||.|:
  Fly   508 SVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKRGTATTPAAGSAAGDARDSAASGPKVIEIDLV 572

  Rat   165 KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVG----LEDVMH 225
            ||.||||||||||:|||||||||.|||||:::||||..||||.||||::||.:.|    ||:|.|
  Fly   573 KGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTH 637

  Rat   226 EDAVAALKNTYDVVYLKVAK----------------PSNAYLSDSYAPPDITTSYSQHLDNEISH 274
            |.|||.||:..|.|.|.:.|                .|...||.|.:  .:.||.||...::..|
  Fly   638 ELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQS--QLATSQSQSQVHQQQH 700

  Rat   275 -------------SSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFN 326
                         |.|..|:...|:.|.:||..|        .|||.||||.|.|.:|..|||||
  Fly   701 ATPMVNSQSTEPGSRYASTNVLAAVPPGTPRAVS--------TEDITREPRTITIQKGPQGLGFN 757

  Rat   327 IVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 391
            |||||||:||::|||||||||||..||::|||:||||.|:|.:|:||:||.|||.:|..||::||
  Fly   758 IVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQ 822

  Rat   392 YKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRF 456
            |:||||:||||:|.:|::|....:.||||. ||:..||..|:|||||||..:|.|..|:.|.|:.
  Fly   823 YRPEEYNRFEARIQELKQQAALGAGGSGTL-LRTTQKRSLYVRALFDYDPNRDDGLPSRGLPFKH 886

  Rat   457 GDVLHVIDAGDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVL 521
            ||:|||.:|.|:||||||||..|:|.:.||.:|||||.||    :::|:|  .|...||
  Fly   887 GDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWER----KMRARD--RSVKFQG------ 939

  Rat   522 SYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSR 586
                      |.|            ||::|     ||..:    ..|.|:.:.. .|.:.|:.||
  Fly   940 ----------HAA------------ANNNL-----DKQST----LDRKKKNFTF-SRKFPFMKSR 972

  Rat   587 EKMEKD 592
            ::..:|
  Fly   973 DEKNED 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg4	NP_062567.1	MAGUK_N_PEST	10..64	CDD:287565	3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..35
		PDZ	65..149	CDD:278991	57/83 (69%)
		PDZ	160..244	CDD:278991	57/87 (66%)
		PDZ_assoc	245..312	CDD:287558	23/95 (24%)
		PDZ	310..394	CDD:214570	56/83 (67%)
		SH3_DLG4	430..495	CDD:212963	37/64 (58%)
		Guanylate_kin	533..711	CDD:279019	13/60 (22%)
		GuKc	544..710	CDD:214504	12/49 (24%)
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187
		PDZ	454..540	CDD:214570	58/85 (68%)
		PDZ_signaling	566..655	CDD:238492	58/88 (66%)
		PDZ_signaling	742..820	CDD:238492	52/77 (68%)
		SH3_DLG-like	862..922	CDD:212795	34/59 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339822
Domainoid	1	1.000	122	1.000	Domainoid score	I5504
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	882	1.000	Inparanoid score	I381
OMA	1	1.010	-	-		QHG52541
OrthoDB	1	1.010	-	-		D349551at33208
OrthoFinder	1	1.000	-	-		FOG0000833
OrthoInspector	1	1.000	-	-		otm44403
orthoMCL	1	0.900	-	-		OOG6_101347
Panther	1	1.100	-	-	O	PTHR23119
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X574
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810