DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc1a2 and Eaat2

DIOPT Version :9

Sequence 1:	NP_058911.2	Gene:	Slc1a2 / 29482	RGDID:	3697	Length:	573	Species:	Rattus norvegicus
Sequence 2:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	226/545 - (41%)
Similarity:	353/545 - (64%)	Gaps:	36/545 - (6%)

- Green bases have known domain annotations that are detailed below.

  Rat    41 LGKNLLLSLTVFGVILGAVCGGLLRLAAPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGL 105
            |.:||:|.:|:.||:||.:.|..|| ...:|.|.:|||::||::.||:||::||||:|||||.|.
  Fly    46 LSENLMLLVTLSGVLLGVILGLSLR-PLNLHGDSIMLISYPGELFMRVLKLMILPLVISSLIAGS 109

  Rat   106 SGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLD 170
            :.|:||.:|::..|.:||:.||:...|.||:.|||.||||||.|............|:.||:.||
  Fly   110 ASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPGNPDLHNADDRSTDRRAVNLLDSLLD 174

  Rat   171 LIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISLLNETMNE-----------APEE 224
            |.||:||:||.||..||..|    |.:..||        ::.:.|||||:           :.:.
  Fly   175 LGRNVFPDNLFQASIQQAHT----VYLPKPS--------ILHVFNETMNDTLASGSEAQRLSEDL 227

  Rat   225 TK-IVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGEQAKLMVEFFNILNEIVMKLVIMIMWYSP 288
            |: :|:.:.::::.|.|.||::.|.:.||..:|.:|::.:::|:||..:.|::||:|..:||.:|
  Fly   228 TEDVVLVRDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLTP 292

  Rat   289 LGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQA 353
            :||:.:|.|||:::.||.:|..||..:::||.:|:.|:..:.:..|||||.|:|||.|:||:.||
  Fly   293 VGISSVIAGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQA 357

  Rat   354 WITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVI 418
            .:||..|||:|..||:||||:.:.|.:|.|:||||||:|..|||||||||.|||:||||||:|::
  Fly   358 MLTAFATASTAAALPITFRCMNEKLKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSGMV 422

  Rat   419 LDGGQIVTVSLTATLASIGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVV 483
            |..|:::||.||:|.||:.:||:|||.||.:|::|||:..|.:|::||.||||.:||:||:.|::
  Fly   423 LGFGELLTVLLTSTAASMSSASVPSAALVLLLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNML 487

  Rat   484 GDSFGAGIVYHLSKSELDTIDSQHRMHEDIEMTKTQSIYDDTKNHRE----------SNSNQCVY 538
            ||.:.|.:|..||:.||..:|:....::|:. ..|.:.:.....|.:          ..|::||.
  Fly   488 GDCYTAAVVEELSRKELMALDAASVNYQDMP-AGTPNGHGHGHGHHDGGLLEGQTELETSSKCVM 551

  Rat   539 AAHNSVVIDECKVTLAANGKSADCS 563
            ...:|||:|...|....|.:...|:
  Fly   552 TMTDSVVVDISAVMNNVNLQQEHCN 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc1a2	NP_058911.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		SDF	46..495	CDD:278787	205/460 (45%)
		Aspartate binding. /evidence=ECO:0000250\|UniProtKB:P43003	361..363		1/1 (100%)
		Aspartate binding. /evidence=ECO:0000250\|UniProtKB:P43003	441..445		2/3 (67%)
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	204/457 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	408	1.000	Domainoid score	I678
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1671
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm44906
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	1	1.100	-	-	O	PTHR11958
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880