DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cd180 and Fili

DIOPT Version :9

Sequence 1:	NP_001099875.1	Gene:	Cd180 / 294706	RGDID:	1308170	Length:	662	Species:	Rattus norvegicus
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	349	Identity:	93/349 - (26%)
Similarity:	145/349 - (41%)	Gaps:	69/349 - (19%)

- Green bases have known domain annotations that are detailed below.

  Rat   351 LYIKGNTKRLELGSGCLETLE-------HLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNE 408
            :.:...||.:.|....:.|||       .|..||||.:.|||....|.:.:  |.|::||||.|.
  Fly    69 IQLNPETKYINLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQ--SELRTLNLSRNL 131

  Rat   409 PLGLRTEAFKECPQLELLDLAFTRLHVKDAQSPFQNLHLLKVLNLSHCLLGSSNQHLLDGLPALR 473
            ...|...|||....|.||||:|.|:.... .:...:|..|..|:|::..:.|...:...|:..|.
  Fly   132 VSSLHKHAFKGLTNLLLLDLSFNRIETVH-PTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLE 195

  Rat   474 HLNLQGNRF---PNGNIQKTNPLQAL----------------GSLEILILSFCD--LSSIDHQAF 517
            .|..:.||.   |..|:...:.|::|                |..|:|.||...  :|.:|..||
  Fly   196 VLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAF 260

  Rat   518 INLKIMNHVDLSHNRLTSSSIEALSHLKGI-YLNLASNRISIIPP--------------SLLPVL 567
            ..|..:.|:|||.|.||....:.||.|..: ||||..||.|.:|.              |.|..|
  Fly   261 EGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFL 325

  Rat   568 -----------SQQRTINLRQN------PLDCTCSNIYFLEWYKENMQKLEDIEDTFCANPPL-- 613
                       :..:|::|..|      |:.....|...||.|.::    ..::..:.|..|:
  Fly   326 QRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQS----NSLQTLYSAQFPVDQ 386

  Rat   614 LRGVKVSDVMLSCSMAAVGIFFLI 637
            |:.:.:.|..|.|:.:.:.::.|:
  Fly   387 LQKLYLGDNPLQCNCSLLWLWRLV 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cd180	NP_001099875.1	leucine-rich repeat	55..78	CDD:275380
		leucine-rich repeat	79..102	CDD:275380
		leucine-rich repeat	103..126	CDD:275380
		leucine-rich repeat	127..150	CDD:275380
		leucine-rich repeat	151..174	CDD:275380
		leucine-rich repeat	175..195	CDD:275380
		leucine-rich repeat	196..223	CDD:275380
		leucine-rich repeat	224..244	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_RI	301..480	CDD:238064	41/135 (30%)
		leucine-rich repeat	301..323	CDD:275380
		LRR_8	322..383	CDD:290566	11/38 (29%)
		leucine-rich repeat	324..347	CDD:275380
		leucine-rich repeat	348..372	CDD:275380	6/27 (22%)
		LRR_8	372..433	CDD:290566	26/60 (43%)
		leucine-rich repeat	373..398	CDD:275380	9/24 (38%)
		leucine-rich repeat	399..422	CDD:275380	10/22 (45%)
		LRR_8	421..482	CDD:290566	16/60 (27%)
		leucine-rich repeat	423..447	CDD:275380	8/23 (35%)
		leucine-rich repeat	448..471	CDD:275380	5/22 (23%)
		leucine-rich repeat	472..498	CDD:275380	8/44 (18%)
		LRR_8	498..556	CDD:290566	24/60 (40%)
		leucine-rich repeat	499..522	CDD:275380	9/24 (38%)
		leucine-rich repeat	523..546	CDD:275380	10/22 (45%)
		TPKR_C2	578..627	CDD:301599	11/56 (20%)
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	6/21 (29%)
		leucine-rich repeat	98..121	CDD:275380	9/24 (38%)
		LRR_8	120..180	CDD:404697	22/60 (37%)
		leucine-rich repeat	122..145	CDD:275380	10/22 (45%)
		leucine-rich repeat	146..169	CDD:275380	8/23 (35%)
		LRR	<161..>354	CDD:227223	48/192 (25%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	12/46 (26%)
		leucine-rich repeat	266..289	CDD:275380	10/22 (45%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	3/23 (13%)
		LRR_8	337..397	CDD:404697	12/63 (19%)
		leucine-rich repeat	339..360	CDD:275380	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100