DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc6a6 and GlyT

DIOPT Version :9

Sequence 1:	XP_008761345.1	Gene:	Slc6a6 / 29464	RGDID:	61912	Length:	631	Species:	Rattus norvegicus
Sequence 2:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster

Alignment Length:	591	Identity:	248/591 - (41%)
Similarity:	352/591 - (59%)	Gaps:	50/591 - (8%)

- Green bases have known domain annotations that are detailed below.

  Rat    36 PGTRPEDEADGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGS 100
            ||.....|::   .:|..|:.:.||:||:.|..||||||||||||||.|||||||||:.|.|..:
  Fly    45 PGAGGAGESE---HERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIA 106

  Rat   101 GLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFQSFQK 165
            |||:.|:|:..|||.:.|.:..:.:.||||.|:|...|::.:::.:||.:|:||..:|:|.||..
  Fly   107 GLPLMFMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAP 171

  Rat   166 DLPWAHCNHSWNTPQCM-----EDTLRRNESHWV-----SLSAA--NFTS---------PVIEFW 209
            .|||.:|..:|:|..|.     :.....|.::::     :.|||  |.|:         |..|::
  Fly   172 VLPWQNCEPAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYF 236

  Rat   210 ERNVLSLSSGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRG 274
            ...||.||.||:..||:|..||.||.|.|.:.|.|:.|||:|:||||||||.||:.:|::|.|||
  Fly   237 NNFVLGLSKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRG 301

  Rat   275 LTLPGAGEGIKFYLYPNISRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLL 339
            :|||||..||.|||.|:..:|.:.|||.||..||||:.:...|.:.:|.||||:..|.|:|.:::
  Fly   302 VTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIV 366

  Rat   340 GCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIM 404
            ...|..|||.:|..||||:||:|.|..||:..|.:.|.|||||.||:.||.:|:...|::|||:|
  Fly   367 AFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVM 431

  Rat   405 LLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAIVCSIS---YLLGLTMVTEGGMYVFQ 466
            ||.|||||||..:|...|:::|.:|:.      |:..|.:|.|::   |:.||...|..|||..|
  Fly   432 LLTLGLDSQFALMETVTTAILDRFPNL------RQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQ 490

  Rat   467 LFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKY---SWAVITPALCVG 528
            |.|.|||:...|| :|..||.:||||||.....:.|:.|||.|...|..:   .|..||||..:.
  Fly   491 LMDKYAANWSVLL-IAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLF 554

  Rat   529 CFIFSLVKYVPLTYNKVYRYPDWAIGLGWGLALSSMVCIPLVIVILLCRTE---GPL----RVRI 586
            ...|:.|:|.|..|.. |.||.||..:||.:.|     :|::::.|:...|   .|:    |.||
  Fly   555 ILFFNWVEYKPAKYGH-YVYPMWADAVGWIVGL-----LPVLVIFLVAFQEIWRAPMSLSFRDRI 613

  Rat   587 KYLITP 592
            |:|:.|
  Fly   614 KHLLQP 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a6	XP_008761345.1	SLC5-6-like_sbd	51..592	CDD:382020	244/574 (43%)
GlyT	NP_611836.2	SNF	57..603	CDD:249680	238/558 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820