DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc6a6 and List

DIOPT Version :9

Sequence 1:	XP_008761345.1	Gene:	Slc6a6 / 29464	RGDID:	61912	Length:	631	Species:	Rattus norvegicus
Sequence 2:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	183/535 - (34%)
Similarity:	284/535 - (53%)	Gaps:	37/535 - (6%)

- Green bases have known domain annotations that are detailed below.

  Rat    47 KPPQR--EKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEV 109
            ||.::  |:|.:.::|:.|.....|||||:|||||:.::||||.|:|||.|.|...|.||::||:
  Fly    12 KPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEI 76

  Rat   110 IIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFQSFQKDLPWAHCNH 174
            .:||:|..|.:..:: :.||..|:....::..:....||..|:|....:...||..:|||:.|..
  Fly    77 SLGQFTGRGVVKAFD-MAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWE 140

  Rat   175 SWNTPQCMEDTLRRNESHWVSLSAANFTSPVIEFWERNVLSLSSGIDHPGSL-KWDLALCLLLVW 238
            ||.| .|.:...:         :::...||...::||.:|.....||:..|| .|.|..||.:.|
  Fly   141 SWGT-DCHDGNAQ---------NSSGKMSPAQLYFEREILHEVPNIDNGLSLPNWQLVACLAIAW 195

  Rat   239 LVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPNISRLEDPQVWID 303
            ||....:.:|::|:||..||...||:.:||:||:|.:|||||.:||.::..|....|.:|.||..
  Fly   196 LVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYA 260

  Rat   304 AGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQG-V 367
            |.||:|||.|||.|.:.:..|||.:..|.|.|.:::..::|.:|.::|...|.|||.:|:|.| .
  Fly   261 AVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNP 325

  Rat   368 DIADVAESGPGLAFIAYPKAVTMMP-LPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSF 431
            ||..|.:.|.|||||:||:|:.... :|..:::|||:||.:||           |.|.|.:....
  Fly   326 DIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLG-----------IGSTVGMGSCI 379

  Rat   432 LRK-----GYRREIFIAIVCSISYL---LGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFV 488
            ||.     |.|......:...::.|   :.:..:|.||.::..|.|:|..|...|: :|..|...
  Fly   380 LRVIRDQFGLRSPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALI-LAIGELVA 443

  Rat   489 IAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPALCVGCFIFSLVKYVPLTYNKVYRYPDWAI 553
            :|||||.:...:.|:.|:|...|.:.:..|..|||.|.....|:.|:....|.|..| .||..|.
  Fly   444 VAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGV-GYPTLAH 507

  Rat   554 GLGWGLALSSMVCIP 568
            ..|..||...::.:|
  Fly   508 VFGCFLATLGLIQLP 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a6	XP_008761345.1	SLC5-6-like_sbd	51..592	CDD:382020	181/531 (34%)
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	170/492 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910