DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gdf11 and scw

DIOPT Version :9

Sequence 1:NP_058899.1 Gene:Gdf11 / 29454 RGDID:2673 Length:405 Species:Rattus norvegicus
Sequence 2:NP_001286088.1 Gene:scw / 46000 FlyBaseID:FBgn0005590 Length:400 Species:Drosophila melanogaster


Alignment Length:370 Identity:86/370 - (23%)
Similarity:136/370 - (36%) Gaps:74/370 - (20%)


- Green bases have known domain annotations that are detailed below.


  Rat    86 RLKEAPNISREVVKQLLPKAPPLQQILD----LHDFQGDALQPEDFL---EEDEYHATTETVISM 143
            |.:..||:.....|.||.....:.:..:    ||.....:|. :|.|   |:.:..|:..::::.
  Fly    53 RRQAEPNLHNSASKFLLEVYNEISEDQEPKEVLHQRHKRSLD-DDILISNEDRQEIASCNSILTF 116

  Rat   144 AQETDPAVQTDGSPLCCHFHFSPK--VMFTKVLKAQLWVYLRP--VPRPATVYLQILRLKPLTGE 204
            :....|. |.| :.|..|..|:..  .:...:::|.|.:|.:|  |.|.|...:.:.|..     
  Fly   117 SSRLKPE-QLD-NELDMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRRANFTVSVYRKL----- 174

  Rat   205 GTAGGGGGGRRHIRIRSL-KIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIE------INAFDP 262
                   ..|:....|.| .:...|....|...:....|..|..    |.|::      |:..|.
  Fly   175 -------DNRQDFSYRILGSVNTTSSQRGWLEFNLTDTLRYWLH----NKGLQRRNELRISIGDS 228

  Rat   263 SGTDLAV---------TSLGP-------GAEGLHPFMELRVLENTKRSRRNLGL-------DCDE 304
            ..:..|.         |||.|       |.|.|....:||...:.::.|...|.       ..|.
  Fly   229 QLSTFAAGLVTPQASRTSLEPFIVGYFNGPELLVKIQKLRFKRDLEKRRAGGGSPPPPPPPPVDL 293

  Rat   305 HSSESRCCRYPLTVDF-EAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHT---------HLVQQ 359
            :.....|.|...|||| |....:|:||||:::|.:|.|.|.:....|...|         ||.|.
  Fly   294 YRPPQSCERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQP 358

  Rat   360 ANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 404
            ..|:    |||.||.:..|.:|.:.::..|...|....|...|||
  Fly   359 HLPK----PCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGC 399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gdf11NP_058899.1 TGFb_propeptide 59..283 CDD:307025 46/230 (20%)
TGFB 311..405 CDD:214556 35/104 (34%)
scwNP_001286088.1 TGFb_propeptide 39..254 CDD:279078 43/219 (20%)
TGFB 300..400 CDD:214556 35/104 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3900
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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