DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak3 and Pak3

DIOPT Version :9

Sequence 1:	XP_008771626.1	Gene:	Pak3 / 29433	RGDID:	3251	Length:	580	Species:	Rattus norvegicus
Sequence 2:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	593	Identity:	229/593 - (38%)
Similarity:	323/593 - (54%)	Gaps:	126/593 - (21%)

- Green bases have known domain annotations that are detailed below.

  Rat    69 EISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKLPDLYGSQMCPGKLPEGIPEQ 133
            ||..|::|:...||..:..||:.                                    ||:|..
  Fly    19 EIGAPTNFQRHFHVSRNQETGDL------------------------------------EGLPAP 47

  Rat   134 WARLLQTSNITKLEQKKNPQAVLDVLKFYD-SKETVNNQKYMSFTSGD------KSAHGYI---- 187
            |.||: .|.||:.||.|||.|....:|:|: |.:...|:.:..|.:.|      |....|:
  Fly    48 WVRLM-NSQITRDEQDKNPDAAYHAVKYYNYSIKKKENEVFKPFITEDVIHEESKEIENYVNYKN 111

  Rat   188 -----------------------------AAHQSNTKTASEPPLAPPVSEEEDEEEEEEEDDN-- 221
                                         :|..||:.:.::......|..:..||..:|...|
  Fly   112 KHKSQDPEKSDDDGSSTATETESSSGCGSSAGNSNSSSINDSSQQSTVPLDALEEVFKELKTNLE 176

  Rat   222 ----------EPPPV--------------IAPRPEHTKSIYTRSVVES---------------IA 247
                      |||||              |.|:|..|:.....|.:..               |.
  Fly   177 HRETLKAAPQEPPPVPPKKSPHTIPPKPQIKPKPRVTQKFSRTSDIRRDEDSDNQHKINTDTIII 241

  Rat   248 SPAAPNKEATPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQ 312
            .||...::|   .|::....|:.|.:  :.|:::.||.||..:||:|.:..||:::|...:::|:
  Fly   242 KPAVGAQDA---GADDNPDETILRRS--KEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGK 301

  Rat   313 GASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLV--GDELW 375
            ||||.|:.|.|:....:||:|.::::.|..|:||:.||.|:::..:.|:||:||:||:  .|:||
  Fly   302 GASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLW 366

  Rat   376 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLT 440
            |||||:.||.||||||||.|.|.|||.||||.|.|:.|||:..:|||||||||:|||||||||:|
  Fly   367 VVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVT 431

  Rat   441 DFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLR 505
            ||||||.|..:: ||.|||||||||||||||||.||.||||||:|||||||:||:||||.|.|||
  Fly   432 DFGFCANIEGDE-KRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLR 495

  Rat   506 ALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLILA 570
            ||||||.||.|::::.::||...:|||:|||:::||||.:|.|||.||||.....:.:|.|.|.|
  Fly   496 ALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALVPNIKA 560

  Rat   571 AKEAIKNS 578
            ||:.::.:
  Fly   561 AKKVLRRN 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	XP_008771626.1	PBD	69..162	CDD:395634	24/92 (26%)
Pak3	XP_008771626.1	STKc_PAK3	284..580	CDD:132987	171/297 (58%)
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	8/53 (15%)
		PKc_like	288..545	CDD:304357	151/243 (62%)
		S_TKc	293..545	CDD:214567	150/238 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820