DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak1 and Pak3

DIOPT Version :9

Sequence 1:	NP_058894.1	Gene:	Pak1 / 29431	RGDID:	3250	Length:	544	Species:	Rattus norvegicus
Sequence 2:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	232/557 - (41%)
Similarity:	323/557 - (57%)	Gaps:	94/557 - (16%)

- Green bases have known domain annotations that are detailed below.

  Rat    74 EISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYN--SKKT 136
            ||..|::|:...||..:..||:..|:|..|.||: .|.||:.||.|||.|....:::||  .||.
  Fly    19 EIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLM-NSQITRDEQDKNPDAAYHAVKYYNYSIKKK 82

  Rat   137 SNS------------------QKYMSF--------TDKSAEDYNS-----------------SNT 158
            .|.                  :.|:::        .:||.:|.:|                 ||:
  Fly    83 ENEVFKPFITEDVIHEESKEIENYVNYKNKHKSQDPEKSDDDGSSTATETESSSGCGSSAGNSNS 147

  Rat   159 LNVKTVSETPAVPPVSEDEDDDDDAT--------------PPPVIAPRPEHTKSVYTRSVIEPLP 209
            .::...|:...||..:.:|...:..|              ||||...:..||  :..:..|:|.|
  Fly   148 SSINDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPPVPPKKSPHT--IPPKPQIKPKP 210

  Rat   210 VTPTRDVATSPISPTEN-------NTTP-----------------PD--ALTRNTEKQKKKPKMS 248
            ....:...||.|...|:       ||..                 ||  .|.|:.||:.:|   :
  Fly   211 RVTQKFSRTSDIRRDEDSDNQHKINTDTIIIKPAVGAQDAGADDNPDETILRRSKEKRAQK---T 272

  Rat   249 DEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIIN 313
            |.||..:||:|.:..||:::|...:::|:||||.|:.|.|:....:||:|.::::.|..|:||:.
  Fly   273 DAEIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILT 337

  Rat   314 EILVMRENKNPNIVNYLDSYLV--GDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQAL 376
            ||.|:::..:.|:||:||:||:  .|:|||||||:.||.||||||||.|.|.|||.||||.|.|:
  Fly   338 EIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAI 402

  Rat   377 EFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYG 441
            .|||:..:|||||||||:|||||||||:|||||||.|..:: ||.|||||||||||||||||.||
  Fly   403 SFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDE-KRQTMVGTPYWMAPEVVTRKKYG 466

  Rat   442 PKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVE 506
            .||||||:||||||||||:||||.|.|||||||||.||.|::::.:|||...:|||:|||:::|:
  Fly   467 KKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVD 531

  Rat   507 KRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNN 543
            :|.:|.|||.|.||.....:.:|.|.|.|||:..:.|
  Fly   532 RRATADELLSHPFLNDCSEVKALVPNIKAAKKVLRRN 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak1	NP_058894.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79		2/4 (50%)
		Autoregulatory region	70..140		27/85 (32%)
		GTPase-binding	70..105		11/30 (37%)
		PBD	74..132	CDD:395634	22/57 (39%)
		Interaction with CRIPAK. /evidence=ECO:0000250	132..269		46/221 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..195		13/75 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..250		14/66 (21%)
		STKc_PAK1	248..543	CDD:270820	170/296 (57%)
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	22/54 (41%)
		PKc_like	288..545	CDD:304357	156/257 (61%)
		S_TKc	293..545	CDD:214567	154/252 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820