Protein Alignment Chrne and nAChRalpha6

DIOPT Version :9

• Sequence 1: XP_017452660.1
• Gene: Chrne / 29422
• RGDID: 2353
• Length: 547
• Species: Rattus norvegicus
• Sequence 2: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 512
• Identity: 150/512 - (29%)
• Similarity: 251/512 - (49%)
• Gaps: 77/512 - (15%)

  Rat    72 QGKNEELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLNEKEETLTTSVWIGIEWQDY 136
            ||.:|: .|.:||...|:...|||....:.:.:...:||..:|.::||.:.|||:.|:.:||.||
  Fly    26 QGPHEK-RLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDY 89

  Rat   137 RLNFSKDDFAGVEILRVPSEHVWLPEIVLENNIDGQFGVAYDCNVLVYEGGSVSWLPPAIYRSTC 201
            .|.:::.::.||:.||:....:|.|::::.|:.|..|...|..|::|...||..::||.|::|||
  Fly    90 NLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTC 154

  Rat   202 AVEVTYFPFDWQNCSLIFRSQTYNAEEVEFIFAVDDDGNAINKIDIDTAAFTENGEWAIDYCPGM 266
            .:::|:||||.|:|.:.|.|.||:..:::.:...:|.|        |.:.|..||||.:...||.
  Fly   155 KIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG--------DLSDFITNGEWYLLAMPGK 211

  Rat   267 IRHYEGGSTEDPGETDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSIN 331
            ..........:| ..|:.:|:.|||:.|:|..|:||||||||.:.||.:.||..: |:|.|:.:.
  Fly   212 KNTIVYACCPEP-YVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS-GEKLTLGVT 274

  Rat   332 VLLAQTVFLFLIAQKIPETSLSVPLLG-----RYLIFVMVVATLI------------VMNC---- 375
            :||:.||||.|:|:.:|.||.:|||:|     ...:|:.:||..:            ..||
  Fly   275 ILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFM 339

  Rat   376 --------VIVLNVSLRTPTTHATSPRLRQILLELLPRLLGLSPPPEDPGAASPARRASSVGILL 432
                    |:|||...||...|...|.::.:.|:.||.:|.:         ..|.|:.:...|||
  Fly   340 VASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRM---------GRPGRKITRKTILL 395

  Rat   433 --RAEELILKKPRSELVF-------EGQRHR-HGTWTAAALCQNLSAAAP--------------- 472
              |.:||.||:..|:.:.       :..||. .|:.|  |:..:.|...|
  Fly   396 SNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQT--AIGSSASFGRPTTVEEHHTAIGCNHK 458

  Rat   473 EVRCCVDAVNFVAESTRDQEATGEELSDWVRMGKALDNVCFWAALVLFSVGSTLIFL 529
            ::...:..:.|:....|..:...|.:.||......:|..|. ....||::.:|:..|
  Fly   459 DLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCL-IVFTLFTIIATVTVL 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chrne	XP_017452660.1	None
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	150/512 (29%)
		LGIC_ECD_nAChR	55..236	CDD:349798	60/189 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000