Protein Alignment Men1 and Mnn1

DIOPT Version :9

• Sequence 1: XP_006230831.1
• Gene: Men1 / 29417
• RGDID: 3078
• Length: 616
• Species: Rattus norvegicus
• Sequence 2: NP_001036342.1
• Gene: Mnn1 / 33991
• FlyBaseID: FBgn0031885
• Length: 763
• Species: Drosophila melanogaster
• Alignment Length: 719
• Identity: 280/719 - (38%)
• Similarity: 376/719 - (52%)
• Gaps: 145/719 - (20%)

  Rat     3 PPAAMGLKAAQKTLFPLRSIDDVVRLFAAEL-GREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE 66
            |.|..|:..|  :||||:|..||:.||...| ...||||.|||:|:|::|..|........
  Fly    12 PMALNGVIDA--SLFPLKSTADVINLFRRALTSGIEPDLTLLSIVVGYIELSLTTGEAAAQ---- 70

  Rat    67 LTFQPSPAPDPPGGLTY---------------FPVADLSIIAALYARFTAQIRGAVDLSLYPREG 116
             ..|.:.|....|.::.               |||....:||.||.:|.. |...|:   .|:..
  Fly    71 -AAQAAAAAVAAGDISQATTGGNDIIMGNSVPFPVVTHELIAGLYKKFQT-ILSVVE---KPKPH 130

  Rat   117 GVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHL 181
            ..::||::|||||||||||.||.:|||||:|:|:|:::|.|||..|||.|||..||.||.:||.|
  Fly   131 RQATREVIKKVSDVIWNSLIRSSYKDRAHLQNLYSYLSGNKLDCFGVALAVVAGCQLLGYKDVRL 195

  Rat   182 ALSEDHAWVVFGSNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMV 246
            |:||||||||||....:|.||||||||:||:|||.:..|:...|||||.|..:.|:|.||||.:.
  Fly   196 AISEDHAWVVFGQKRVETIEVTWHGKGSEDKRGQDIRPGIESGSWLYLGGLAVVCERGMEVAAIC 260

  Rat   247 CAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKG 311
            .|:|.|:..::|.:|:.:|||:|||||||||||:|||||||.|.:|||:..|........||.:.
  Fly   261 AALNISLTSNSDCVEVAELQQQLLWLLYDLGHLKRYPMALGTLGELEEIHRTHPSISCEQLYREA 325

  Rat   312 IASAKTYYQDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNY-CREDEEIYKEFFEVAN 375
            |.||:|:|::.|:|||.|...|:.|....|:|..|||:.|.||:.|.| ||:|||||||..::||
  Fly   326 IESARTHYRNHHVYPYTYQGNYYNRLLKYRDAFAAWANAADVIRLYTYQCRDDEEIYKELLDIAN 390

  Rat   376 DVIPNLLKEAASLLEAGEERPGEQAQGTQGQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHV 440
            ::||.::|..:|         |..|:      |.|:|.|.||:|||||||||:|||.|.||:||:
  Fly   391 ELIPYVMKTESS---------GHSAR------SILRDSEVFANLLRFYDGICQWEEDSLTPILHI 440

  Rat   441 GWATFLVQSLGRFEGQVRQKVHI-----------------VSREA-EAAEAEEPWGDEAREG--- 484
            |||..||.::.:|:..:|.:|.|                 ..:|| ||.|::|..|.||.||
  Fly   441 GWAKPLVNNITKFDYDIRSQVVIKLPEDLEAEQAKAELARAEQEAKEAKESKEAAGSEAMEGNNN 505

  Rat   485 RRRGPRRESKPEEPPPP----------------------KKPALD--KGPGSGQS---------- 515
            |......:||..|.|..                      .:|..|  :.|..|:|
  Fly   506 RMATKEEKSKNSELPTTLADLTAACGEKILNPDFLLQGGGQPFADQKQQPSGGESDNPELHNNNN 570

  Rat   516 ------------------AGSGPPRKTSGTVSGTARGTEVSSAAQAPAPAAS------------- 549
                              |.:.....|:...|||:....|||.|.....|.|
  Fly   571 NSNSNNNNNNHNADKKEAAATTTNATTTSNGSGTSVQLPVSSEANNAGQAQSQVQINDQLGKPQH 635

  Rat   550 ------------PPPE----GPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKV 598
                        .|.|    .||:|..|:||||:|:||:|.|:|:.||.||:||||....|.:.|
  Fly   636 KEAKKEETSDDYDPFEIMLKRPVITLYSQKMKGLKDLLLAEKLNTHAISLQVTAQSVASRKVRGV 700

  Rat   599 STPS 602
            ...|
  Fly   701 EKHS 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Men1	XP_006230831.1	Menin	8..614	CDD:282857	278/714 (39%)
		Menin	9..464	CDD:271218	218/488 (45%)
Mnn1	NP_001036342.1	Menin	17..464	CDD:271218	218/472 (46%)
		Menin	18..714	CDD:282857	277/713 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349414
Domainoid	1	1.000	403	1.000	Domainoid score	I706
eggNOG	1	0.900	-	-		E1_2CNB7
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7418
Inparanoid	1	1.050	453	1.000	Inparanoid score	I1555
OMA	1	1.010	-	-		QHG49672
OrthoDB	1	1.010	-	-		D346541at33208
OrthoFinder	1	1.000	-	-		FOG0006939
OrthoInspector	1	1.000	-	-		oto96214
orthoMCL	1	0.900	-	-		OOG6_108783
Panther	1	1.100	-	-	LDO	PTHR12693
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5031
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770