DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt3 and JIL-1

DIOPT Version :9

Sequence 1:	XP_038946556.1	Gene:	Akt3 / 29414	RGDID:	62390	Length:	504	Species:	Rattus norvegicus
Sequence 2:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster

Alignment Length:	381	Identity:	138/381 - (36%)
Similarity:	204/381 - (53%)	Gaps:	53/381 - (13%)

- Green bases have known domain annotations that are detailed below.

  Rat   141 NCSPTSQIDNIGEEEMDASTT--------HHKRKTMNDFDYLKLLGKGTFGKVILVREKA---SG 194
            |.:|....:...:.:::|.|.        ..:..::|||..:::||.|.:|:|.|||:..   :|
  Fly   223 NSTPLDLDNEAHQRDLEAVTDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAG 287

  Rat   195 KYYAMKILKKEVIIAKDEVA-HTLTESRVLKN-TRHPFLTSLKYSFQTKDRLCFVMEYVNGGELF 257
            |.||||:|.|..::.|.:.| ||.||..||:. .|:|||.||.|:||:..:|..|:::.||||||
  Fly   288 KLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELF 352

  Rat   258 FHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITD 322
            .||.....|.|.|.|.|.||:|.||:.||...|:|||:||||::||.:|||.::||||.|  |..
  Fly   353 THLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSK--ILT 415

  Rat   323 AAT---MKTFCGTPEYLAPEVLEDNDYGR--AVDWWGLGVVMYEMMCGRLPFYNQD----HEKLF 378
            |..   ..:||||.||:|||::.....|.  |||||.:||:.:|::.|..||...|    ..::.
  Fly   416 AENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEIS 480

  Rat   379 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKMTT 443
            ..|..|....|.:.|::|:..:..:|.|:|.:||||...||.||..|.||:|:|||::..|:
  Fly   481 RRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRTKR--- 542

  Rat   444 TAWTAWIMSGGHTSLSSPTLQAD------GNKFLSVCLYTVILDFATENDSWTSPP 493
                       ..:...|||.|:      .|:|         .|...|:....:||
  Fly   543 -----------RKAPYKPTLTAEDDVQNFSNEF---------TDQVPEDPECDAPP 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt3	XP_038946556.1	PH_PKB	4..133	CDD:269947
Akt3	XP_038946556.1	PKc_like	175..442	CDD:419665	121/280 (43%)
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	115/270 (43%)
		STKc_MSK_N	266..533	CDD:270735	116/268 (43%)
		S_TK_X	532..591	CDD:214529	15/70 (21%)
		S_TKc	632..886	CDD:214567
		PKc_like	632..885	CDD:304357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910