DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt3 and S6k

DIOPT Version :9

Sequence 1:	XP_038946556.1	Gene:	Akt3 / 29414	RGDID:	62390	Length:	504	Species:	Rattus norvegicus
Sequence 2:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	276	Identity:	129/276 - (46%)
Similarity:	184/276 - (66%)	Gaps:	4/276 - (1%)

- Green bases have known domain annotations that are detailed below.

  Rat   170 DFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVIIA-KDEVAHTLTESRVLKNTRHPF 230
            ||:..|:||||.:|||..||:.|   :.||:|||:|||..|:. :.:.|||..|..:|:..:|||
  Fly    76 DFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPF 140

  Rat   231 LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDL 295
            :..|.|:|||..:|..::||::|||||.||.||.:|.||.|.||.:||:.||.:||...|:||||
  Fly   141 IVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDL 205

  Rat   296 KLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMY 360
            |.||::||..||:|:||||||||.|.:.....|||||.||:|||:|..:.:|:|||||.||.:|:
  Fly   206 KPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMF 270

  Rat   361 EMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRH 425
            :|:.|..||..::.:|..|.||...:..|..|:.:|:.|:..|:.:...:|||.||:||..:..|
  Fly   271 DMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIH 335

  Rat   426 SFFSGVNWQDVYDKKM 441
            .||..|||.||..:::
  Fly   336 PFFKHVNWDDVLARRL 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt3	XP_038946556.1	PH_PKB	4..133	CDD:269947
Akt3	XP_038946556.1	PKc_like	175..442	CDD:419665	127/271 (47%)
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	129/276 (47%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	127/271 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810