DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adra1a and Oamb

DIOPT Version :9

Sequence 1:	NP_058887.2	Gene:	Adra1a / 29412	RGDID:	2055	Length:	466	Species:	Rattus norvegicus
Sequence 2:	NP_001262774.1	Gene:	Oamb / 43982	FlyBaseID:	FBgn0024944	Length:	751	Species:	Drosophila melanogaster

Alignment Length:	695	Identity:	170/695 - (24%)
Similarity:	244/695 - (35%)	Gaps:	314/695 - (45%)

- Green bases have known domain annotations that are detailed below.

  Rat    20 PVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSA 84
            |.|:....:|..|  .:::.|  ||.|||.:|.|...|.|||:::||||||||||:...||||||
  Fly    18 PANLISLAVLEFI--NVLVIG--GNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSA 78

  Rat    85 IFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLC 149
            .:|:...|.||.::|.||.||||..|||||:.||.||:|||:.|:.|:.||:|::.::....:..
  Fly    79 TWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAG 143

  Rat   150 VWVLSLVISIGPLFGWR------QP---------------------------------------- 168
            :||||..|...||.||:      ||
  Fly   144 IWVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSP 208

  Rat   169 ----------------APED--------------------------------------------- 172
                            ||.|
  Fly   209 PHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQ 273

  Rat   173 ---ETI-------CQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKS 227
               :||       |::..:.||||:|||||||:|:.::|..|.|:|..|.|.:|.:..|.||.|.
  Fly   274 NRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKG 338

  Rat   228 --------DSEQVTLRIHR---------------------------------------------- 238
                    :.:::||||||
  Fly   339 SKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIK 403

  Rat   239 ----------------------------------------------------------------- 238

  Fly   404 ISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQ 468

  Rat   239 --KNVP-----------AEGGGVSSAKNK----THFSVRLLKFSREKKAAKTLGIVVGCFVLCWL 286
              |.:|           |.|.|.|...||    .:...::.:|..|.||||||.|:||.|:.||.
  Fly   469 VGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWC 533

  Rat   287 PFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL-RIQCLR--- 347
            |||.:..|..|..|. ....:|.::|||||.||.:||:||...|::|:.||:.:: |..|.|
  Fly   534 PFFTMYIIRPFCQDC-VDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIICRCFCSRQSV 597

  Rat   348 -----RRQSSKHALGYTLHPPS-------------------------------------QALEGQ 370
                 ||.|...|:......||                                     .:|.|.
  Fly   598 SLKSSRRGSDMSAIRIRARTPSITPSAAAHSFGDESELHHSEMSNDPRXRSFGPSSSSQSSLGGL 662

  Rat   371 HRDMVRIPVGSGETFYKISK---TDGVCEWKFFSSMPQGSARITV 412
            .:..:::||      |:|..   .:..| :.:..:...|||..:|
  Fly   663 RKTSLKVPV------YEICHPLVMETAC-YSYVEATSDGSASCSV 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adra1a	NP_058887.2	7tmA_alpha1A_AR	27..337	CDD:320448	146/562 (26%)
		TM helix 1	29..53	CDD:320448	9/23 (39%)
		TM helix 2	62..84	CDD:320448	14/21 (67%)
		TM helix 3	100..122	CDD:320448	14/21 (67%)
		TM helix 4	145..161	CDD:320448	5/15 (33%)
		TM helix 5	182..205	CDD:320448	13/22 (59%)
		TM helix 6	271..293	CDD:320448	13/21 (62%)
		TM helix 7	305..330	CDD:320448	12/24 (50%)
		Nuclear localization signal. /evidence=ECO:0000250	334..349		5/23 (22%)
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	62/128 (48%)
Oamb	NP_001262774.1	7tm_1	37..>181	CDD:278431	66/143 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68078
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2726
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1095345at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.970