DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acvr1b and sax

DIOPT Version :9

Sequence 1:	NP_954700.1	Gene:	Acvr1b / 29381	RGDID:	735207	Length:	505	Species:	Rattus norvegicus
Sequence 2:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	224/515 - (43%)
Similarity:	301/515 - (58%)	Gaps:	63/515 - (12%)

- Green bases have known domain annotations that are detailed below.

  Rat    36 CTSC-------LQTNYTCETDGACMVS-IFNLDGMEHHVRTCIPKVELVPAGKPFYC------LS 86
            |.||       .:..:||:....|..| ..:.||.....|.|    ...|...|..|      ::
  Fly    79 CYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGC----STSPDQLPMICSQNSLKIN 139

  Rat    87 SEDLRNTH------CCYIDFCNKIDLRVPSGHLKEPEHPSMWGPVE-----------------LV 128
            ....|||.      ||..|:||            |.:.|.:. |.:                 ||
  Fly   140 GPSKRNTGKFVNVVCCAGDYCN------------EGDFPELL-PFDSNDVTVITADTSSISKMLV 191

  Rat   129 GIIAGPVFLLFLI--IIIVFLVINYHQRVYHNRQRLDME-----DPSCEMCLSKDKTLQDLVYDL 186
            .:: ||..::.|:  :.|.|:..::.:|:..:|.:.|.|     |.......:.|.||::.:...
  Fly   192 AVL-GPFLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHS 255

  Rat   187 STSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIY 251
            .||||||||||.||||:|:.:.|.|.||:|::||||||.|.|..:|||||.||:|.||.||.|||
  Fly   256 VTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIY 320

  Rat   252 QTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLA 316
            .|::||||||||||.:|.....:.|||||::.|:..|||||:|||..::...|:.:.||.|:||.
  Fly   321 STILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLV 385

  Rat   317 HLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYM 381
            |||.||.|.||||.:||||||||||||..||.|.|||.||||.|..||..:|:..|.:|||||||
  Fly   386 HLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYM 450

  Rat   382 APEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKV 446
            |||||||:|:::.|::.:..||||.|||.||:.||..|.|:.|||::|:||:||.|||.|:||||
  Fly   451 APEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKV 515

  Rat   447 VCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQL-SVQEDVKI 505
            ||....||::||.|.|...:..|.|:|:|||:.|...||.|||||||:.:| |..|.:::
  Fly   516 VCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acvr1b	NP_954700.1	Activin_recp	38..104	CDD:395845	21/85 (25%)
		GS	177..207	CDD:197743	17/29 (59%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..498	CDD:271045	166/287 (58%)
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	24/104 (23%)
		TM_EGFR-like	182..218	CDD:213052	7/36 (19%)
		TGF_beta_GS	247..274	CDD:285687	16/26 (62%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	169/296 (57%)
		TyrKc	276..553	CDD:197581	157/276 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820