DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acvr1b and tkv

DIOPT Version :9

Sequence 1:	NP_954700.1	Gene:	Acvr1b / 29381	RGDID:	735207	Length:	505	Species:	Rattus norvegicus
Sequence 2:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	246/545 - (45%)
Similarity:	318/545 - (58%)	Gaps:	88/545 - (16%)

- Green bases have known domain annotations that are detailed below.

  Rat    23 GSGP----------------RGIQALLCACT-SCLQ--TNYTCET--DGACMVSIFNL----DGM 62
            ||||                ...::|.|.|. ||..  :|.||||  .|:|..::..|    .||
  Fly    56 GSGPGSEGYEDADNEKSKTVENARSLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGM 120

  Rat    63 EHHVRT--CIP----------KVELVP--AGKPFYCLSSEDLRNTHCCYIDFCNKIDL---RVPS 110
            ....||  |:|          ||..||  .||...|...|          ||||: ||   ..|.
  Fly   121 YEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKE----------DFCNR-DLYPTYTPK 174

  Rat   111 GHLKEPEHP---------SMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQ-RLDME 165
            .....|:.|         :::|.:    ||:..||:|    |:..|...|.:|....:| ||
  Fly   175 LTTPAPDLPVSSESLHTLAVFGSI----IISLSVFML----IVASLCFTYKRREKLRKQPRL--- 228

  Rat   166 DPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGD 230
              ...||.|:...|..||.  .:|||||||||.||||:|:.|.:..::||||:||||..:||...
  Fly   229 --INSMCNSQLSPLSQLVE--QSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDER 289

  Rat   231 VAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN 295
            ||||.|.:.||.|||||.||||||::||:|||||||||.|.||:|||:.|::||||.|||.|||:
  Fly   290 VAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLS 354

  Rat   296 RYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH 360
            ...:..:.:..||.|.||||||||.||.||.|||.|||||:||||||||:||.|||||.||||::
  Fly   355 MSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKY 419

  Rat   361 DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS--GGVH 423
            ::..|.|.||.|.||||:||||||||.:.::.|.|:.||.||:|::|||.||:.|||.:  .|..
  Fly   420 NSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTK 484

  Rat   424 ----EEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAAR 484
                |:|.|||:|:|||||:.|:|..|||.:..||.:|:.||..:.|..:.|:|:|||:.|...|
  Fly   485 TTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVR 549

  Rat   485 LTALRIKKTLSQLS----VQEDVKI 505
            |||||:||||.:|.    :...:||
  Fly   550 LTALRVKKTLGRLETDCLIDVPIKI 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acvr1b	NP_954700.1	Activin_recp	38..104	CDD:395845	28/87 (32%)
		GS	177..207	CDD:197743	17/29 (59%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..498	CDD:271045	169/292 (58%)
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	33/100 (33%)
		GS	238..266	CDD:197743	17/29 (59%)
		S_TKc	267..557	CDD:214567	165/289 (57%)
		STKc_BMPR1	270..562	CDD:271046	169/291 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750