DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mpdz and Patj

DIOPT Version :9

Sequence 1:	XP_006238402.1	Gene:	Mpdz / 29365	RGDID:	3105	Length:	2068	Species:	Rattus norvegicus
Sequence 2:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster

Alignment Length:	1050	Identity:	341/1050 - (32%)
Similarity:	458/1050 - (43%)	Gaps:	368/1050 - (35%)

- Green bases have known domain annotations that are detailed below.

  Rat     6 DKNRALQAAERLQSKLKERGD----VANEDKLSLLKSVLQSPLFSQILSLQTSLQQLKDQVNVAT 66
            |.:.|||..|.::..:.|..|    :...:.||.:..:||.|:|..|:.:|.||.:|
  Fly     6 DISSALQQIEAVKKGIDESDDPKLQMQTAESLSTILGILQDPVFRTIVHVQDSLSEL-------- 62

  Rat    67 LATANADHAHTP-----QFSSAIISNLQSESLLLSPSNGNL-----------EAISGPGAPPAMD 115
                ||..|..|     .|...:..|     |:||.:.|.:           .:.|.||:|.
  Fly    63 ----NAQLAQHPSMLPNDFDIDVAGN-----LVLSLNGGEVMYDFDEQRSSSHSHSAPGSPD--- 115

  Rat   116 GKPACEELDQLIKSMAQGRHVEIFELLKPPCGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRD 180
                        ||                 ||:|
  Fly   116 ------------KS-----------------GGVG------------------------------ 121

  Rat   181 GRLKETDQILAINGQVLDQTITHQQAISILQKAKDTIQLVIARGSLPHISSPRISRSPSAASTVS 245
                                                             ..||.....|..:.|
  Fly   122 -------------------------------------------------EEPRPQSQNSKGAGV- 136

  Rat   246 AHSNPTHWQHVETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTD 310
            |....|.:..::.|||||||:||||||||.:.:||||||||||||||:.|||.||||||:|||.:
  Fly   137 ADLYATDYAQIQAIELVNDGTGLGFGIIGARNSGVIVKTILPGGVADKDGRLRSGDHILQIGDVN 201

  Rat   311 LAGMSSEQVAQVLRQCGNRVKLMIARGAVEETPAPS--------------------------SLG 349
            |..|.|||||.||||.|..|:|::||...:..|.|.                          |.|
  Fly   202 LHEMVSEQVAAVLRQSGTHVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTG 266

  Rat   350 I--------TLSSSTSTSE-----------MRVDASTQKNE-----ESETFDVELTKNVQGLGIT 390
            .        |.|:..:|:|           |.:|.:....|     |:|...|||.|:..|||||
  Fly   267 YPEIFGESSTASTPQTTTEDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVELKKDANGLGIT 331

  Rat   391 IAGYIGDKKLEPSGIFVKSITKSSAVELDGRIQIGDQIVAVDGTNLQGFTNQQAVEVLRHTGQTV 455
            ||||:.:|: |.|||||||::..||.:|.|||::.|:|:.|||.:|||::|.||||:|:.:||.|
  Fly   332 IAGYVCEKE-ELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVV 395

  Rat   456 RLTLMR--KG----------ASQEAEITSREDTAKDVDLPAE---------------NYEKDEES 493
            .|.|.|  :|          |:.:...:|...|.....:|..               ..|.:||:
  Fly   396 NLRLERYLRGPKFEQLQQAIAANDKLPSSAPGTPSRAPMPTPVATTSSATTTPSRSITRELEEEA 460

  Rat   494 L-----------------------------------SLKRSTSILPIEEEGYPLLS--------- 514
            |                                   ||..||.|:|.|.  .||..
  Fly   461 LPAPEAFMTTPPSVTTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEV--VPLADKTEAKNSGV 523

  Rat   515 -------TELEETEDVQQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVG------ 566
                   |:.|.::|.:.|  ::.|||:|:|.:.|::||.:.||:. .|||||||.||.
  Fly   524 ITRHKYYTDPELSDDAETE--IIRKWQKIVGSDVEVIVAQIKKFAV-GGLGISLEGTVDVEGGRE 585

  Rat   567 ---HHFIRSVLPEGPVGHSGKLFSGDELLEVNGINLLGENHQDVVNILKELPIDVTMVCCRR--- 625
               ||:|||:||:||||.:|.|.||||||||||..|||.||.:||.||||||:||.|||.|.
  Fly   586 VRPHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAILKELPLDVRMVCGRNRNS 650

  Rat   626 --------TVPPTALSEVDSLDIHDLELTEKPHIDLGEFIGSSETEDPMLA----MSDVDQNAEE 678
                    |:...:.:..:.|...|..:..|....|.. .||....|.:.|    .|.:...:.|
  Fly   651 SLLPFSDDTLKKLSNNFENLLPATDRLVKAKSDGSLAT-AGSVADGDSVAAAAASFSKLKSRSLE 714

  Rat   679 IQTPLAMWEAGIQAIELEKGSRGLGFSILDYQDPIDPANTVIVIRSLVPGGIAEKDGRLFPGDRL 743
            ..|.||||.:..|.|||.||.|||||||||||||:||.:|:||||||||||:|:.||||.|||||
  Fly   715 PLTGLAMWSSQPQIIELVKGDRGLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGRLIPGDRL 779

  Rat   744 MFVNDINLENSTLEEAVEALKGAPSGMVRIGVAKPLPLSPEEGYVSAKEDTFLCSPHTCKEMGLS 808
            :|||.|||||::|::||:|||||..|:||||||||||::
  Fly   780 LFVNSINLENASLDQAVQALKGASKGVVRIGVAKPLPMT-------------------------- 818

  Rat   809 DKALFRADLALIDTPDAESVAESRFESQFSPDNDSVYSTQASVLSLHDGACSDGMNYGPSLPSSP 873
                   |.:|....:|.:.:|...::|.||                           |:||:..
  Fly   819 -------DNSLKACSNASTTSEETLDAQPSP---------------------------PALPTVA 849

  Rat   874 PKDVTNSSDL 883
            |..:..|:.:
  Fly   850 PPAMPPSASM 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mpdz	XP_006238402.1	L27_2	6..63	CDD:117611	18/60 (30%)
		PDZ_signaling	140..222	CDD:238492	3/81 (4%)
		PDZ_signaling	256..335	CDD:238492	55/78 (71%)
		PDZ	374..463	CDD:214570	49/90 (54%)
		PDZ_signaling	552..621	CDD:238492	47/77 (61%)
		PDZ_signaling	693..776	CDD:238492	62/82 (76%)
		PDZ_signaling	993..1063	CDD:238492
		PDZ_signaling	1150..1241	CDD:238492
		PDZ	1348..1433	CDD:214570
		PDZ_signaling	1482..1561	CDD:238492
		MPDZ_u10	1563..1624	CDD:293272
		PDZ	1625..1709	CDD:214570
		PDZ_signaling	1721..1801	CDD:238492
		PDZ_signaling	1858..1943	CDD:238492
		PDZ_signaling	1984..2067	CDD:238492
Patj	NP_477342.1	L27	12..70	CDD:295425	18/69 (26%)
		PDZ_signaling	154..226	CDD:238492	51/71 (72%)
		PDZ_signaling	318..400	CDD:238492	46/82 (56%)
		PDZ_signaling	557..643	CDD:238492	51/86 (59%)
		PDZ_signaling	726..807	CDD:238492	59/80 (74%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5164
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003499
OrthoInspector	1	1.000	-	-		otm44956
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	LDO	PTHR19964
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.810