DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mpdz and inaD

DIOPT Version :9

Sequence 1:	XP_006238402.1	Gene:	Mpdz / 29365	RGDID:	3105	Length:	2068	Species:	Rattus norvegicus
Sequence 2:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	718	Identity:	187/718 - (26%)
Similarity:	312/718 - (43%)	Gaps:	136/718 - (18%)

- Green bases have known domain annotations that are detailed below.

  Rat  1153 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDL 1217
            |.|.:...||.||.||.|.   .:.|......|||||.::.||||...|.||.||||:.::|.|:
  Fly    30 VTLDKTGKKSFGICIVRGE---VKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRILSLNGKDV 91

  Rat  1218 RDASHEQAVEAIRKAGSPVVFMVQSIVNRPRKSPLPSLPHSLYPKCSFSSTNPFAESLQLTSDKA 1282
            |:::.:..::.|::|...:...:|:. ::..:....|.|.|   .....:.|.|.:. |.|::.|
  Fly    92 RNSTEQAVIDLIKEADFKIELEIQTF-DKSDEQQAKSDPRS---NGYMQAKNKFNQE-QTTNNNA 151

  Rat  1283 PS-------------------QSESESEKATLCSVPSSSPSVFSEMSSDYAQPSATTVA------ 1322
            ..                   |...:....|..:......|.:::...:..:.....:.
  Fly   152 SGGQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRTEAGYE 216

  Rat  1323 -----------------EDEDKEDEFGYSWKNIQERYGTLTGQLHMIELEKGHS-GLGLSLAGNK 1369
                             .|:::||||||:...|.:||..:. .|..||:::..| .|||:|||:|
  Fly   217 IDRASAGNCKLNKQEKDRDKEQEDEFGYTMAKINKRYNMMK-DLRRIEVQRDASKPLGLALAGHK 280

  Rat  1370 DRTRMSVFIVGIDPTGAAGRDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNA 1434
            ||.:|:.|:.|:||.||.| ...::..||::|:||.:|..|.|.|||::.|..... |::.|.:.
  Fly   281 DRQKMACFVAGVDPNGALG-SVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNVDGD-KLVMITSR 343

  Rat  1435 DAVNQMAVCPGSAADPL---PSTSES--------PQNKEVEPSITTSASAVDLSSLTNVYHLELP 1488
            ...|...:|    ..|:   |:.|:.        |:.:.|:                       .
  Fly   344 RKPNDEGMC----VKPIKKFPTASDETKFIFDQFPKARTVQ-----------------------V 381

  Rat  1489 KDQGGLGIAIC---EEDTLNGVTIKSLTERGGAAKDGRLKPGDRILAVDDELVAGCPIEKFISLL 1550
            :.:|.|||.:.   ..:..:|:.|..|.| |..|:...:|.||.:|||:.::......:....||
  Fly   382 RKEGFLGIMVIYGKHAEVGSGIFISDLRE-GSNAELAGVKVGDMLLAVNQDVTLESNYDDATGLL 445

  Rat  1551 KTAK---TTVKLTVGAENPGCQAVPSAAVTASGERKDSSQTPAVPAPDLEPIPSTSRSSTPAIFA 1612
            |.|:   |.:.||:.:|. ..:|..:|......|.|...:.|
  Fly   446 KRAEGVVTMILLTLKSEE-AIKAEKAAEEKKKEEAKKEEEKP----------------------- 486

  Rat  1613 SDPATCPIIPGCETTIEISKGQTGLGLSIVGGSD--TLLGAIIIHEVYEEGAACKDGRLWAGDQI 1675
            .:|||..|.|..:..||:...:..:|:.:.||.:  ...|.:|.| ||.||....|.||...|.|
  Fly   487 QEPATAEIKPNKKILIELKVEKKPMGVIVCGGKNNHVTTGCVITH-VYPEGQVAADKRLKIFDHI 550

  Rat  1676 LEVNG--IDLRKATHDEAINVLRQTPQR-VRLTLYRDEAPYKEEDVCDTFTVELQKRPGKGLGLS 1737
            .::||  |.:...|..:...:...|.:: |.||::|.:.|..|:     |.|:|.|:.||.||||
  Fly   551 CDINGTPIHVGSMTTLKVHQLFHTTYEKAVTLTVFRADPPELEK-----FNVDLMKKAGKELGLS 610

  Rat  1738 IVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVG 1802
            :  ..|:.|..::|:::|...:.|.:|.:||.|...||:.:.....:...||.|.:.|.|::||.
  Fly   611 L--SPNEIGCTIADLIQGQYPEIDSKLQRGDIITKFNGDALEGLPFQVCYALFKGANGKVSMEVT 673

  Rat  1803 RIK 1805
            |.|
  Fly   674 RPK 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mpdz	XP_006238402.1	L27_2	6..63	CDD:117611
		PDZ_signaling	140..222	CDD:238492
		PDZ_signaling	256..335	CDD:238492
		PDZ	374..463	CDD:214570
		PDZ_signaling	552..621	CDD:238492
		PDZ_signaling	693..776	CDD:238492
		PDZ_signaling	993..1063	CDD:238492
		PDZ_signaling	1150..1241	CDD:238492	31/87 (36%)
		PDZ	1348..1433	CDD:214570	35/85 (41%)
		PDZ_signaling	1482..1561	CDD:238492	22/84 (26%)
		MPDZ_u10	1563..1624	CDD:293272	11/60 (18%)
		PDZ	1625..1709	CDD:214570	25/88 (28%)
		PDZ_signaling	1721..1801	CDD:238492	26/79 (33%)
		PDZ_signaling	1858..1943	CDD:238492
		PDZ_signaling	1984..2067	CDD:238492
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	31/87 (36%)
		PDZ_signaling	259..340	CDD:238492	34/82 (41%)
		PDZ_signaling	377..457	CDD:238492	22/103 (21%)
		PDZ_signaling	500..584	CDD:238492	24/84 (29%)
		PDZ_signaling	597..672	CDD:238492	25/76 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9916
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1419918at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820