DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oprk1 and AstC-R1

DIOPT Version :9

Sequence 1:	XP_038965287.1	Gene:	Oprk1 / 29335	RGDID:	69426	Length:	431	Species:	Rattus norvegicus
Sequence 2:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	392	Identity:	130/392 - (33%)
Similarity:	199/392 - (50%)	Gaps:	54/392 - (13%)

- Green bases have known domain annotations that are detailed below.

  Rat    52 MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSV-----------GSEDQQLEPAHI 105
            |...:|..:||   ..|.|..   |:::|:      ::|.|:           ||...|.|.:..
  Fly     6 MMDVLQFVKGE---MTADSEA---NATNWY------NTNESLYTTELNHRWISGSSTIQPEESLY 58

  Rat   106 SPAIPV-------------IITAV-YSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALAD 156
            ...:|.             :.|.| |..|.::||.||:||::|::|::||:|.|||||.|||:||
  Fly    59 GTDLPTYQHCIATRNSFADLFTVVLYGFVCIIGLFGNTLVIYVVLRFSKMQTVTNIYILNLAVAD 123

  Rat   157 ALVTTTMPFQSAVYLMN--SWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALD 219
            ......:||  .:|.|.  ||.||:.:||..:.......|||...|.:||.|||||||||:.:..
  Fly   124 ECFLIGIPF--LLYTMRICSWRFGEFMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPR 186

  Rat   220 FRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVF 284
            :||...||:::...|..::.:.:..|:...|..:||.....|::.:||...........:..|..
  Fly   187 YRTLHIAKVVSAIAWSTSAVLMLPVILYASTVEQEDGINYSCNIMWPDAYKKHSGTTFILYTFFL 251

  Rat   285 AFVIPVLIIIVCYTLMILRLKSVRLLSG--SREKDRNLRRITKLVLVVVAVFIICWTPIHIFILV 347
            .|..|:..|:..|.|:|.:|:||....|  |:||.|..|::|:|||.|::|:|:||.| | :|..
  Fly   252 GFATPLCFILSFYYLVIRKLRSVGPKPGTKSKEKRRAHRKVTRLVLTVISVYILCWLP-H-WISQ 314

  Rat   348 EALGSTSHSTAVLSSYYFCI-----ALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQS 407
            .||..::.:...||.....|     ||.|:||::||:|||||.|||::.|    |.....|.:|.
  Fly   315 VALIHSNPAQRDLSRLEILIFLLLGALVYSNSAVNPILYAFLSENFRKSF----FKAFTCMNKQD 375

  Rat   408 TN 409
            .|
  Fly   376 IN 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oprk1	XP_038965287.1	7tmA_Kappa_opioid_R	111..392	CDD:320219	110/303 (36%)
		TM helix 1	113..137	CDD:320219	11/24 (46%)
		TM helix 2	146..167	CDD:320219	11/20 (55%)
		TM helix 3	183..205	CDD:320219	6/21 (29%)
		TM helix 4	228..244	CDD:320219	1/15 (7%)
		TM helix 5	275..298	CDD:320219	4/22 (18%)
		TM helix 6	324..346	CDD:320219	11/21 (52%)
		TM helix 7	360..385	CDD:320219	14/29 (48%)
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	108/287 (38%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	96/262 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010