DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GSK3A and gsk-3

DIOPT Version :9

Sequence 1:	NP_063937.2	Gene:	GSK3A / 2931	HGNCID:	4616	Length:	483	Species:	Homo sapiens
Sequence 2:	NP_001379044.1	Gene:	gsk-3 / 173149	WormBaseID:	WBGene00001746	Length:	362	Species:	Caenorhabditis elegans

Alignment Length:	328	Identity:	250/328 - (76%)
Similarity:	286/328 - (87%)	Gaps:	2/328 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    97 SGK-VTTVVATLG-QGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNR 159
            ||| ||.|||::. .|.::..|::|.|.|||||||||||:.|:|:.|.|:|||||||||||||||
Worm    12 SGKQVTMVVASVATDGVDQQVEISYYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKRFKNR 76

Human   160 ELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVY 224
            ||||||||:|.|||:|:|||||||||||||||||:||||||||||||||::|.:..||::|||:|
Worm    77 ELQIMRKLNHPNIVKLKYFFYSSGEKKDELYLNLILEYVPETVYRVARHYSKQRQQIPMIYVKLY 141

Human   225 MYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPE 289
            ||||.||||||||.|:|||||||||||:||::.|||||||||||.|||.||||||||||||||||
Worm   142 MYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRNEPNVSYICSRYYRAPE 206

Human   290 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF 354
            ||||||:||:||||||||.|:||||||||||||||||||||||||||||||||||:.|||||.||
Worm   207 LIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMNPNYKEF 271

Human   355 KFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPL 419
            ||||||||||.|||:..||.|||.|.|.::||||:||.:|..||.|:||||||....:||:.|||
Worm   272 KFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFFDELRNPDARLPSGRPL 336

Human   420 PPL 422
            |.|
Worm   337 PTL 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GSK3A	NP_063937.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96
		STKc_GSK3	114..406	CDD:271039	231/291 (79%)
		Pkinase	119..403	CDD:278497	227/283 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..483
gsk-3	NP_001379044.1	STKc_GSK3	31..323	CDD:271039	231/291 (79%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161454042
Domainoid	1	1.000	482	1.000	Domainoid score	I210
eggNOG	1	0.900	-	-		E2759_KOG0658
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	524	1.000	Inparanoid score	I733
Isobase	1	0.950	-	0	Normalized mean entropy	S376
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328711at33208
OrthoFinder	1	1.000	-	-		FOG0000635
OrthoInspector	1	1.000	-	-		otm15589
orthoMCL	1	0.900	-	-		OOG6_100482
Panther	1	1.100	-	-	LDO	PTHR24057
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R530
SonicParanoid	1	1.000	-	-		X378
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.780