DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Itgb3 and Itgbn

DIOPT Version :9

Sequence 1:	NP_714942.1	Gene:	Itgb3 / 29302	RGDID:	628868	Length:	787	Species:	Rattus norvegicus
Sequence 2:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster

Alignment Length:	814	Identity:	259/814 - (31%)
Similarity:	393/814 - (48%)	Gaps:	84/814 - (10%)

- Green bases have known domain annotations that are detailed below.

  Rat     9 LWATLLALGALAGVVVGESNICTTRGVNSCQQCLAVSPVCAWCSDESLPQNSPRCNLKKNLLKDK 73
            ||..|:.|.|.......:|.....|..:||::||:....||||:|:.. |...||..::.||...
  Fly    10 LWIYLVFLIAEISHSDADSIDDQCRHADSCERCLSAHLECAWCTDKEY-QVGYRCLSRRQLLNYN 73

  Rat    74 CSPESIEFPVSEAQILEALPLSSKGSGDSAQITQVSPQRIALRLRPDDSKIFSLQVRQVEDYPVD 138
            ||...|........:|:..||....:.|  |..||:|||..|:|...:::...|..|...:.|:|
  Fly    74 CSETDIYENQPVLDVLQDKPLKDYETSD--QAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLD 136

  Rat   139 IYYLMDLSFSMKDDLSSIQTLGTKLASQMRKLTSNLRIGFGAFVDKPVSPYMFISPPQAIKNPCY 203
            :|.||||:::|:||..:::.||.:|:..::.||.|.|:|||:|.|||..|.:.   ||..:|||.
  Fly   137 LYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMIL---PQHRENPCA 198

  Rat   204 TMKSTCLPMFGYKHVLTLTDQVTRFNDEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDAS 268
            ..::||.|.:||:|.|:|||.:..|...|....::.|.|..|||.||:||..||.::|||:..|.
  Fly   199 AERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQAR 263

  Rat   269 HLLVFTTDAKTHIALDGRLAGIVLPNDGRCHIGPDNHYSASTTMDYPSLGLMTEKLSQKNINLIF 333
            .:::..||...|:|.||.||||:..||.:||:.....|:.|...|||||..:..:|.::.||:||
  Fly   264 KVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIF 328

  Rat   334 AVTENVVSLYQNYSELIPGTT-VGVLSDDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNA 397
            ||||.|||.|...|.|:...: |.:||.||||:|:||..:|..:..:.:. ..:.|:.:.:::..
  Fly   329 AVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQF-ADNSPDFIDMAYYT 392

  Rat   398 TCLNNEVIPGLKS---CVGLKIGDTVSFSIEAKVRGCPQQKEQSFT----IKPVGFKDSLTVQVT 455
            .|  ....|.|:.   |..:.:|..:.|.::..::..|.  .|.:|    ::.....:.:.:.|.
  Fly   393 DC--GGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYPD--NQVYTHKIRVEETSLSEFMDLDVE 453

  Rat   456 FDCDCDCQAFAQPLSPRCNNGNGTF--------ECGVCRCDQGWLGSMCECSEEDYRPSQQEECS 512
            ....|.||....|     .|..|.|        .||:|.||:||.|:.|.|..:....:..|...
  Fly   454 LQRPCPCQETPDP-----ENEEGRFLCDYKGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALL 513

  Rat   513 PKEGQP---------ICSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCN 568
            .|..||         :||..|:|.||.|:|   |.| .||.:|||.:  |:....::    ..|.
  Fly   514 QKCRQPFSDKSTSELVCSNHGDCDCGTCLC---DPG-YTGPFCECRE--CLDCDEKL----ADCF 568

  Rat   569 CGDCVCDSDWTGYYCNCTTRTDTCMSTNGLLCSGRGNCECGSCVCVQPGSYGDTCEKCPTCPD-A 632
            ||.|||...|:|..|||...||.|:...|.:||.||.|:|..|.|.:| ..|..||..|...: .
  Fly   569 CGQCVCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKL 632

  Rat   633 CSFKKDCVECKKFNRGKLHEENNCNRFCRDDIELVKELTDTGKNAVNCTYK---NEDDCVVR--- 691
            |.|.:.||.|       |.|:......|.:..|:...|........|..::   .:|.|:||
  Fly   633 CLFYEPCVTC-------LIEQKQGMGVCENLTEICSSLDRQETYPYNFVHELDPEQDQCLVRLVN 690

  Rat   692 --------FQYYE--DSSGRAVLYVVE-EPECPKGPDILVVLLSVMGAILLIGLATLLIWKLLIT 745
                    |..|:  |.|....:..|: ||     ||.:.::..:....|||||..:.|....|.
  Fly   691 KHGIQCDSFFVYQVIDHSNFLTIQAVDCEP-----PDYVALVGYISAFTLLIGLLIIFIILWYIR 750

  Rat   746 IHDRKEFAKFEEERARAKWDTANNPLYKEATSTF 779
            ..|.:|:|||||::..:.  ...||:|::....:
  Fly   751 AKDAREYAKFEEDQKNSV--RQENPIYRDPVGRY 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgb3	NP_714942.1	INB	37..460	CDD:197563	146/430 (34%)
		CX3CL1-binding. /evidence=ECO:0000250\|UniProtKB:P05106	202..209		1/6 (17%)
		Involved in CX3CL1-, NRG1-, FGF1-and IGF1-binding. /evidence=ECO:0000250\|UniProtKB:P05106	202..209		1/6 (17%)
		CX3CL1-binding. /evidence=ECO:0000250\|UniProtKB:P05106	292..312		6/19 (32%)
		Cysteine-rich tandem repeats. /evidence=ECO:0000250\|UniProtKB:O54890	462..628		63/182 (35%)
		I-EGF_1	462..491	CDD:375798	11/36 (31%)
		Integrin_B_tail	633..716	CDD:369622	22/99 (22%)
		Integrin_b_cyt	743..785	CDD:370082	11/37 (30%)
		LIR. /evidence=ECO:0000250\|UniProtKB:P05106	776..782		0/4 (0%)
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	147/432 (34%)
		EGF_2	524..552	CDD:285248	12/31 (39%)
		Integrin_b_cyt	748..785	CDD:285884	11/37 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920