DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gata6 and grn

DIOPT Version :9

Sequence 1:	NP_062058.2	Gene:	Gata6 / 29300	RGDID:	2666	Length:	587	Species:	Rattus norvegicus
Sequence 2:	NP_001262366.1	Gene:	grn / 40962	FlyBaseID:	FBgn0001138	Length:	712	Species:	Drosophila melanogaster

Alignment Length:	631	Identity:	192/631 - (30%)
Similarity:	250/631 - (39%)	Gaps:	187/631 - (29%)

- Green bases have known domain annotations that are detailed below.

  Rat     5 DGGWCLPKRFGAAAADAGDSGPFPAREPSSPLSPISSSSSSCSRGGDRGPCGASNCRTPQLDTEA 69
            :||...|:..|     .|.:|...|....|..|..||:.||...|...|..|.|...|..:....
  Fly    30 NGGGVSPQTNG-----LGSAGSSLAHSHHSLSSGASSAGSSVGVGSALGGGGGSGLDTSDMSAFY 89

  Rat    70 VAGPPGRSLLLSP-YTSHPFAAAHGAAAPGVAGP--GSALSTWEDLLLFTDLDQAATASKLLWSS 131
            .....|......| |..|........|:|.|..|  .:.||.|    |.::....|.||  .||
  Fly    90 ALESNGHHRRYYPSYHQHTSRMPSTHASPQVCRPHFHTPLSPW----LTSEHKSFAPAS--AWS- 147

  Rat   132 RGAKLSPFAAEQPEEM----------YQTLAA------------------LSSQGPAAYDGAPGG 168
                :..||..|..::          :||.||                  ....||:.|......
  Fly   148 ----MGQFACPQEPQVEHKLGQMGQSHQTTAAGQHSFPFPPTPPKDSTPDSVQTGPSEYQAVMNA 208

  Rat   169 FVHSAAAAAAAAAAASSPVYVPTTRVGSMLPGLPYLQ-GAGSGPSNHAGGAGAHPGWP------- 225
            |:|..|..:.:...||..:.:.           |.:| |:.||.|   |....|...|
  Fly   209 FMHQQATGSTSLTDASCALDIK-----------PSIQNGSASGSS---GSGTTHTSTPKQREGTA 259

  Rat   226 ---------------------------QASADSPPYGGGGAAGGGAAGPGGAGSATAHASARFPY 263
                                       |:|:::.......|:...||....|..|.:.|::
  Fly   260 STTNSSSNSSSSQQQQQQQQQQQQQQQQSSSNTTASSNTSASSSAAAASLSAAVAASAATS---- 320

  Rat   264 SPSPPMANGAARDPGGYVAAGGAGAGSVSGGGGSLAAMGGRE-------------HQYSSLSAAR 315
                  :||.........::||:|.|   |||||  ..||.:             ||.::::||.
  Fly   321 ------SNGLFDGTAQAYSSGGSGGG---GGGGS--GSGGYDTSSYASYHHAAAHHQAAAVAAAN 374

  Rat   316 PLNGT----------------YHHHHHHHPTY------------------SPYMGAPLTPAWPAG 346
            ....:                :|||||||..:                  :..||:....:..||
  Fly   375 MFQSSSVAAAAVRHSMAAAQAHHHHHHHHSGHHHSGSSSGLHGLGGSVGGTAGMGSMSGNSGGAG 439

  Rat   347 PFETPVLHSLQSRAGA----------PLPVPRGPSADLLEDLSESRECVNCGSIQTPLWRRDGTG 401
                    ||...:||          ..||...|...     :|.|||||||:..||||||||||
  Fly   440 --------SLSGHSGAGSNAGSNCLDVKPVRTKPRTS-----AEGRECVNCGATSTPLWRRDGTG 491

  Rat   402 HYLCNACGLYSKMNGLSRPLIKPQKRV------PSSRRLGLSCANCHTTTTTLWRRNAEGEPVCN 460
            ||||||||||.||||.:||||||::|:      .:::|.|.|||||.|||||||||||.||||||
  Fly   492 HYLCNACGLYYKMNGQNRPLIKPKRRLTLQSLQSAAKRAGTSCANCKTTTTTLWRRNASGEPVCN 556

  Rat   461 ACGLYMKLHGVPRPLAMKKEGIQTRKRKPKNINKSKACSGNSSVPM 506
            |||||.|||.|.|||.|||||||||.||..:.:|.|...|...:|:
  Fly   557 ACGLYYKLHNVNRPLTMKKEGIQTRNRKLSSKSKKKKGLGGGCLPI 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gata6	NP_062058.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..73		14/55 (25%)
		GATA-N	147..371	CDD:283099	63/343 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..259		14/83 (17%)
		ZnF_GATA	382..429	CDD:214648	38/52 (73%)
		ZnF_GATA	383..428	CDD:238123	36/44 (82%)
		ZnF_GATA	435..482	CDD:214648	39/46 (85%)
		ZnF_GATA	437..488	CDD:238123	43/50 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..532		12/27 (44%)
grn	NP_001262366.1	ZnF_GATA	470..517	CDD:214648	38/46 (83%)
		ZnF_GATA	473..517	CDD:238123	36/43 (84%)
		ZnF_GATA	529..578	CDD:214648	40/48 (83%)
		ZnF_GATA	533..583	CDD:238123	43/49 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810