Protein Alignment SLC25A6 and DPCoAC

DIOPT Version :10

• Sequence 1: NP_001627.2
• Gene: SLC25A6 / 293
• HGNCID: 10992
• Length: 298
• Species: Homo sapiens
• Sequence 2: NP_650891.1
• Gene: DPCoAC / 42429
• FlyBaseID: FBgn0067783
• Length: 365
• Species: Drosophila melanogaster
• Alignment Length: 297
• Identity: 97/297 - (32%)
• Similarity: 148/297 - (49%)
• Gaps: 36/297 - (12%)

Human    13 LAGGIAAAISKTAVAPIERVKLLLQVQH-ASKQIAADKQYKGIVDCIVRIPKEQGVLSFWRGNLA 76
            ::|..|.|::||.:||::|.|:..|::: ......|..:|      :......:|||:.||||.|
  Fly    77 ISGAAAGALAKTVIAPLDRTKINFQIRNDVPFSFRASLRY------LQNTYANEGVLALWRGNSA 135

Human    77 NVIRYFPTQALNFAFKDKYKQIFLGGVDK---HTQFWRYFAGNLASGGAAGATSLCFVYPLDFAR 138
            .:.|..|..|:.|...:::::|.  .|||   :|:..|:.||:|     ||.||....||||.||
  Fly   136 TMARIVPYAAIQFTAHEQWRRIL--HVDKDGTNTKGRRFLAGSL-----AGITSQSLTYPLDLAR 193

Human   139 TRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAK---- 199
            .|:|.....:|    :|.|.....||...:|.|.|::|:..:|.|:|.|....|..|:|.|
  Fly   194 ARMAVTDRYTG----YRTLRQVFTKIWVEEGPRTLFRGYWATVLGVIPYAGTSFFTYETLKREYY 254

Human   200 GMLPDPK-NTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMM-MQSGRKGADIMYTGTVDCWRKIF 262
            .::.:.| ||  :||........|.....|||.|.|||||. |:....|.| .|...::...||:
  Fly   255 EVVGNNKPNT--LVSLAFGAAAGAAGQTASYPLDIVRRRMQTMRVNTAGGD-RYPTILETLVKIY 316

Human   263 RDEGGK-AFFKGAWSNVLRG---MGGAFVLVLYDELK 295
            |:||.| .|:||...|.::|   :|.:|  ..||.:|
  Fly   317 REEGVKNGFYKGLSMNWIKGPIAVGISF--STYDLIK 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC25A6	NP_001627.2	PTZ00169	3..298	CDD:240302	97/297 (33%)
		Solcar 1	6..98		24/85 (28%)
		Solcar 2	111..201		33/93 (35%)
		Solcar 3	212..297		32/89 (36%)
		Important for transport activity. /evidence=ECO:0000250|UniProtKB:P12235	235..240		4/5 (80%)
		Nucleotide carrier signature motif. /evidence=ECO:0000250|UniProtKB:P02722	235..240		4/5 (80%)
DPCoAC	NP_650891.1	PTZ00169	77..336	CDD:240302	91/278 (33%)