DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clip2 and mud

DIOPT Version :9

Sequence 1:	NP_068837.2	Gene:	Clip2 / 29264	RGDID:	62019	Length:	1047	Species:	Rattus norvegicus
Sequence 2:	NP_727769.3	Gene:	mud / 44839	FlyBaseID:	FBgn0002873	Length:	2567	Species:	Drosophila melanogaster

Alignment Length:	892	Identity:	193/892 - (21%)
Similarity:	347/892 - (38%)	Gaps:	250/892 - (28%)

- Green bases have known domain annotations that are detailed below.

  Rat   341 LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHI-----------CEVE 394
            |....|.|..:...:..||...:..||.::.|..|.:.||.|:|...|.|           |:.|
  Fly  1155 LALVKSAYEAQTKLSDDLQRQKESGQQLVDNLKVELEKERKELAHVNSAIGAQTKLSDDLECQKE 1219

  Rat   395 -----------------KEIALLKAQHEQYVAEAEEKL--------QRARLLVENV-------RK 427
                             ||:|.:|:     |.||:.||        :.|:.||:|:       ||
  Fly  1220 SGQQLVDNLKVELEKERKELAQVKS-----VIEAQTKLSDDLQREKESAQQLVDNLKVELDKERK 1279

  Rat   428 EKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGE----------LEQSLLLEK 482
            |...:::..|.:.:..:|||.:.|.......:|:.:...|...:.:          |...|..||
  Fly  1280 ELAQVNSAFEAQTKLSDDLQRQKESAQQLVDNLKVELDKERKELAQVNSAFEAQTKLSDDLQREK 1344

  Rat   483 AQAERLLREL---ADNRLTTVAEKSRVLQLEEELSLRRGEIEELQHCLLQSGPPPADH------P 538
            ..|::|:..|   .|.....:|:...|::.:.:||      ::||. ..:|.....|:      .
  Fly  1345 ESAQQLVDNLKVELDKERKELAQVKSVIEAQTKLS------DDLQR-QKESAQQLVDNLKVELDK 1402

  Rat   539 EAAETLRLR-----ERLLSASKEHQRDS-------TLLQDKYEHMLKTYQTEVDKLRAANEKYAQ 591
            |..|..:::     :..||...:.|::|       |.|.|..:...::.|..||.|:...:|..:
  Fly  1403 ERKELAKVKSVIEAQTKLSDDLQRQKESAQQLEAQTKLSDDLQRQKESAQQLVDNLKVELDKERK 1467

  Rat   592 EVADLKAKVQQAT----------TENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKE 646
            |:|.:|:.::..|          .....|:||.|.:||.    .:|.|..:|:.:    |||.|.
  Fly  1468 ELAQVKSVIEAQTKLSDDLQRQKESAQQLVDNLKMELDK----ERKELAQVKSAI----GAQTKL 1524

  Rat   647 IGELKA-------LVEGIKME---HQLELGNLQAKHDLETAMHG-----KE---------KEGLR 687
            ..:|:.       ||:.:|:|   .:.||..:.:..:.:|.:..     ||         ||.|.
  Fly  1525 SDDLECQKESVQQLVDNLKVELEKERKELAKVNSAFEAQTKLSDDLKLQKEDAQREVFLVKERLV 1589

  Rat   688 QKLQEAQEELAGLQQ-----HWR-AQLEEQASQHRLELQEAQDQCRD------AQLRVQ--ELEG 738
            ::.:|.:.:||.|:.     ..| .|:||:.:....::.:.:::|::      :||:|:  ::|.
  Fly  1590 KEKREFEVKLATLEDIIETLEMRCTQMEEERATAYEQINKLENRCQEKDNVKSSQLQVETFKVEC 1654

  Rat   739 LDVEYRGQAQAIEFLKEQIS--LAEK-KMLDY-----------------------------EMLQ 771
            |..:.:.:......|.|.::  |||| ..||:                             |:..
  Fly  1655 LHHQLKSEMATHNSLVEDLNRKLAEKVSKLDFVQSRLMTEIAEHNQVKDQLAQITDIPKVVELQH 1719

  Rat   772 RAEAQSRQEAERLREKLLVAENRLQAV-ESLCSAQHSHVIESNDLSEEKIRMKETVEGLQDKLNK 835
            |.||:: .|.|..:.||.|...||..: ..|.:|:..|       ..:.:||:||...:.:|
  Fly  1720 RLEAET-AEREEAQNKLAVVTGRLDEITRELDNARLEH-------GAQILRMEETAREVGNK--- 1773

  Rat   836 RDKEVAALTSQMDMLRAQVSALENKCKSGEKKIDSLLKEKRRLEAELEAVSRKTHD--------- 891
                .|.|...::..|.:|.|||.          .||...:.|| ||.::.....:
  Fly  1774 ----NAELCELIEFYRNRVEALER----------LLLASNQELE-ELNSIQSNQAEGVRDLGDTY 1823

  Rat   892 --ASGQLVHISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDD--IR 952
              |.|:.....|:..|.::...:.::|        ....||...|:.:.|.:||:|:|:.:  :.
  Fly  1824 SAAEGRQTESDQDKERYQKLALDCKIL--------QAKYRDAKDEIKRCEKKIKDQRLEMEGKLE 1880

  Rat   953 GLREKLTGL--------------DKEKSLSEQKRYSLIDPASAPELLRLQHQLVSTEDALRDALD 1003
            .::.|:..|              |..||.||.:..:..:........:|.:|:|...:.:   |:
  Fly  1881 KMKNKMRSLYTAEVTRMKEKQERDAAKSASELEALTAQNAKYEEHTRKLSNQIVRLNEKI---LE 1942

  Rat  1004 QAQQVERLVEALRGC----------SDRTQTISNSGSA-NGIHQPDK 1039
            |.:|...:...||..          |..|.|:|:|.|| |...||.|
  Fly  1943 QQKQHAIISTNLRHLQMQPISETKPSSTTLTVSSSSSAPNDDWQPFK 1989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clip2	NP_068837.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72
		CAP_GLY	82..146	CDD:396049
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..216
		CAP_GLY	222..286	CDD:396049
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..340
		Smc	<357..1016	CDD:224117	177/840 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1022..1047		10/19 (53%)
mud	NP_727769.3	SMC_prok_B	319..1178	CDD:274008	5/22 (23%)
		SCP-1	853..1571	CDD:114219	95/435 (22%)
		Smc	1234..>1944	CDD:224117	161/766 (21%)
		DUF948	1392..1517	CDD:295114	28/128 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000