Protein Alignment Clip2 and CLIP-190

DIOPT Version :10

• Sequence 1: NP_068837.2
• Gene: Clip2 / 29264
• RGDID: 62019
• Length: 1047
• Species: Rattus norvegicus
• Sequence 2: NP_001368962.1
• Gene: CLIP-190 / 35042
• FlyBaseID: FBgn0020503
• Length: 1795
• Species: Drosophila melanogaster
• Alignment Length: 1329
• Identity: 325/1329 - (24%)
• Similarity: 569/1329 - (42%)
• Gaps: 375/1329 - (28%)

  Rat    11 GRGGKHSSPV-GRPSIGSASS-------SVVASASGSKEGSPLHKQASGPSSAGATTTVSE---- 63
            |......||| ..|..|:.:|       |.:.:.:.|..|.|...:...|||.|:|.:||:
  Fly    10 GTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPQPSKMKAPSSFGSTGSVSKIGRP 74

  Rat    64 -------KPGPKAAEV------GDDFLG-------------------DFVVGERVWVNGVKPGVV 96
                   |.||...|.      .||.|.                   .|::|:|||:.|.:||.:
  Fly    75 CCNHTTPKSGPPPREATSMSRESDDNLSSINSAYTDNSSAVLTANTEQFIIGQRVWLGGTRPGQI 139

  Rat    97 QYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPAAEGSGSDAHS 161
            .::|:|.||.|:|||||||:|.|||||.|.|.|||:|...:|||:|.::||..|.|     .|.:
  Fly   140 AFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRLTTYPLA-----GAQT 199

  Rat   162 VESLTAQNLSLHSGTATPPLTGRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGDKDLHLGDRV 226
            ..|..|::....|.|.:|..:     :|.|:|.|. ..|.::|               :.:||||
  Fly   200 PTSPLAKSSPDRSRTVSPTAS-----IRSSMLRSP-GIGGKNG---------------MAVGDRV 243

  Rat   227 LVG---GTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIR 288
            :|.   |::.|::||:|||.||.|.|||||||||.|||||.|...|||:|.||:|:|.||.||
  Fly   244 IVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV-- 306

  Rat   289 IGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKIS 353
                |.||: :|||:     :|......|.:||.:::|:|::...| .|.......||...:.|.
  Fly   307 ----SLSPS-SKKTR-----LSRTGSRESLTSIGTMNSIATTATSR-MRMNAQQRKSSTPVKPIL 360

  Rat   354 GTT----ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEI----------------- 397
            .|.    ::|:.|:|||||:|:|:.||||:|.:   |.:...:::|.|
  Fly   361 ATPKSQFSMQDLLREKQQHVEKLMVERDLDRED---AQNQALQLQKNINEVIIFTDTMYAPLPYA 422

  Rat   398 -----------ALLKAQHEQYV------------------------------------------- 408
                       :.:|...:|::
  Fly   423 DRSRPYRPSKKSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAAACNRQPLQQQQQ 487

  Rat   409 AEAEEKLQRAR-LLVENVRKEK--------VDLSNQLEEERRKVEDLQFRVEEESITKGDLETQT 464
            ....:|.|:|: ..|....|:|        |:|.:.|:.||:|.|:||..::|......:|..|:
  Fly   488 PHLHQKQQQAKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQS 552

  Rat   465 QLEHARIGELEQSLLLEKAQAERLLRELADNRLTT--VAEKSRVLQLEEELSLRRGEIEELQHCL 527
            |:...:|.:|| |.:.:...|...|:.:....|.:  .|.:..:.:|:|::::::.|:|.
  Fly   553 QVYKEKIHDLE-SKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVES----- 611

  Rat   528 LQSGPPPADHPEAAETLR-----LRERLLSASKE-HQRDSTLLQDKY---EHMLKTYQTEVDKLR 583
                 ..|:..|..:.||     |.|::.:...| ..:|..|  :|:   |..::..:.|::.|:
  Fly   612 -----RIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEAL--EKFSLSECGIENLRRELELLK 669

  Rat   584 AANEKYAQEV-ADLKAKVQQATTENMGL---MDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQ 644
            ..|||.|||. |:...|:.:.:.|.:.|   :.|.|:..|||.|:.....::.: .|.:....:.
  Fly   670 EENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECE-ILQTEVRMRD 733

  Rat   645 KEIGELKALVEGIKMEHQLELGNLQAKHDL-----------ETAMHGKEKEGLRQKLQEA----- 693
            ::|.||...::.:..:..::..:..|..|:           .|.:...|||.::.|.|.|
  Fly   734 EQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLND 798

  Rat   694 ----QEELAGLQQHW---------------RAQLEEQASQHRL-----ELQEAQDQCRDAQLRVQ 734
                :::::.|:|..               :.|||:::.:.:|     ||::.|.:..::::.:|
  Fly   799 KEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQ 863

  Rat   735 ELEG----LDVEYRGQAQAIEFLKEQISLAEKKMLDYEMLQRAEAQSRQEAER-LREKLLVAENR 794
            |::.    .|.|.....::::.|::|:   |:|.|.:|.||.|..:.::|.|. ::||    |..
  Fly   864 EIKAQNTQKDFELVESGESLKKLQQQL---EQKTLGHEKLQAALEELKKEKETIIKEK----EQE 921

  Rat   795 LQAVESLCSAQHS--HVIE------------------------SNDLSEEKIRMKET---VEGLQ 830
            ||.::|..:...|  .|::                        .:::|:.|.:.:||   ::..|
  Fly   922 LQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQ 986

  Rat   831 DKLNKRDKEVAA--------------LTSQMDMLRAQVSALENKCKSGEKKIDSLLKEKRRLEAE 881
            ..|..:.|::.|              |..|:..|:::|...:....|....::|..|:.....|.
  Fly   987 SNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAA 1051

  Rat   882 LEAVSR---------------------------KTHDASGQLVHI-------------------- 899
            ||.|::                           :...:|...:|.
  Fly  1052 LEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKA 1116

  Rat   900 ---SQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 961
               |||:|:||:.|.|||..|.::..         |:...|||...||:..::.|:.|:|::|..
  Fly  1117 DAWSQEMLQKEKELQELRQQLQDSQD---------SQTKLKAEGERKEKSFEESIKNLQEEVTKA 1172

  Rat   962 DKEK-SLSEQKRYSLIDPASAPEL--LRLQH-QLVSTEDALRDALDQAQQVERLVEALRGCSDRT 1022
            ..|. .||...:.::.|.....|:  ..||| :.:::|||.:.|     .::.||||::..:
  Fly  1173 KTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIA-----DLKTLVEAIQVAN--- 1229

  Rat  1023 QTISNSGSANG----IHQPDKAHKQEDKH 1047
               :|..:.|.    :.:..:|.|.|..|
  Fly  1230 ---ANISATNAELSTVLEVLQAEKSETNH 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clip2	NP_068837.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..72		21/79 (27%)
		CAP_GLY	82..146	CDD:460154	35/63 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..216		2/19 (11%)
		CAP_GLY	222..286	CDD:460154	40/66 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	314..340		7/25 (28%)
		Smc	<357..>954	CDD:440809	163/829 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1022..1047		5/28 (18%)
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	25/107 (23%)
		CAP_GLY	125..189	CDD:460154	35/63 (56%)
		CAP_GLY	239..306	CDD:460154	40/66 (61%)
		SMC_prok_B	<546..912	CDD:274008	80/382 (21%)
		SMC_prok_B	743..1596	CDD:274008	105/540 (19%)
		COG4913	<1534..>1703	CDD:443941
		CLIP1_ZNF	1726..1743	CDD:465212
		CLIP1_ZNF	1773..1789	CDD:465212