DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Clip2 and CLIP-190

DIOPT Version :9

Sequence 1:NP_068837.2 Gene:Clip2 / 29264 RGDID:62019 Length:1047 Species:Rattus norvegicus
Sequence 2:NP_001368962.1 Gene:CLIP-190 / 35042 FlyBaseID:FBgn0020503 Length:1795 Species:Drosophila melanogaster


Alignment Length:1329 Identity:325/1329 - (24%)
Similarity:569/1329 - (42%) Gaps:375/1329 - (28%)


- Green bases have known domain annotations that are detailed below.


  Rat    11 GRGGKHSSPV-GRPSIGSASS-------SVVASASGSKEGSPLHKQASGPSSAGATTTVSE---- 63
            |......||| ..|..|:.:|       |.:.:.:.|..|.|...:...|||.|:|.:||:    
  Fly    10 GTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPQPSKMKAPSSFGSTGSVSKIGRP 74

  Rat    64 -------KPGPKAAEV------GDDFLG-------------------DFVVGERVWVNGVKPGVV 96
                   |.||...|.      .||.|.                   .|::|:|||:.|.:||.:
  Fly    75 CCNHTTPKSGPPPREATSMSRESDDNLSSINSAYTDNSSAVLTANTEQFIIGQRVWLGGTRPGQI 139

  Rat    97 QYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPAAEGSGSDAHS 161
            .::|:|.||.|:|||||||:|.|||||.|.|.|||:|...:|||:|.::||..|.|     .|.:
  Fly   140 AFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRLTTYPLA-----GAQT 199

  Rat   162 VESLTAQNLSLHSGTATPPLTGRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGDKDLHLGDRV 226
            ..|..|::....|.|.:|..:     :|.|:|.|. ..|.::|               :.:||||
  Fly   200 PTSPLAKSSPDRSRTVSPTAS-----IRSSMLRSP-GIGGKNG---------------MAVGDRV 243

  Rat   227 LVG---GTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIR 288
            :|.   |::.|::||:|||.||.|.|||||||||.|||||.|...|||:|.||:|:|.||.||  
  Fly   244 IVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV-- 306

  Rat   289 IGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKIS 353
                |.||: :|||:     :|......|.:||.:::|:|::...| .|.......||...:.|.
  Fly   307 ----SLSPS-SKKTR-----LSRTGSRESLTSIGTMNSIATTATSR-MRMNAQQRKSSTPVKPIL 360

  Rat   354 GTT----ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEI----------------- 397
            .|.    ::|:.|:|||||:|:|:.||||:|.:   |.:...:::|.|                 
  Fly   361 ATPKSQFSMQDLLREKQQHVEKLMVERDLDRED---AQNQALQLQKNINEVIIFTDTMYAPLPYA 422

  Rat   398 -----------ALLKAQHEQYV------------------------------------------- 408
                       :.:|...:|::                                           
  Fly   423 DRSRPYRPSKKSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAAACNRQPLQQQQQ 487

  Rat   409 AEAEEKLQRAR-LLVENVRKEK--------VDLSNQLEEERRKVEDLQFRVEEESITKGDLETQT 464
            ....:|.|:|: ..|....|:|        |:|.:.|:.||:|.|:||..::|......:|..|:
  Fly   488 PHLHQKQQQAKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQS 552

  Rat   465 QLEHARIGELEQSLLLEKAQAERLLRELADNRLTT--VAEKSRVLQLEEELSLRRGEIEELQHCL 527
            |:...:|.:|| |.:.:...|...|:.:....|.:  .|.:..:.:|:|::::::.|:|.     
  Fly   553 QVYKEKIHDLE-SKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVES----- 611

  Rat   528 LQSGPPPADHPEAAETLR-----LRERLLSASKE-HQRDSTLLQDKY---EHMLKTYQTEVDKLR 583
                 ..|:..|..:.||     |.|::.:...| ..:|..|  :|:   |..::..:.|::.|:
  Fly   612 -----RIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEAL--EKFSLSECGIENLRRELELLK 669

  Rat   584 AANEKYAQEV-ADLKAKVQQATTENMGL---MDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQ 644
            ..|||.|||. |:...|:.:.:.|.:.|   :.|.|:..|||.|:.....::.: .|.:....:.
  Fly   670 EENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECE-ILQTEVRMRD 733

  Rat   645 KEIGELKALVEGIKMEHQLELGNLQAKHDL-----------ETAMHGKEKEGLRQKLQEA----- 693
            ::|.||...::.:..:..::..:..|..|:           .|.:...|||.::.|.|.|     
  Fly   734 EQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLND 798

  Rat   694 ----QEELAGLQQHW---------------RAQLEEQASQHRL-----ELQEAQDQCRDAQLRVQ 734
                :::::.|:|..               :.|||:::.:.:|     ||::.|.:..::::.:|
  Fly   799 KEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQ 863

  Rat   735 ELEG----LDVEYRGQAQAIEFLKEQISLAEKKMLDYEMLQRAEAQSRQEAER-LREKLLVAENR 794
            |::.    .|.|.....::::.|::|:   |:|.|.:|.||.|..:.::|.|. ::||    |..
  Fly   864 EIKAQNTQKDFELVESGESLKKLQQQL---EQKTLGHEKLQAALEELKKEKETIIKEK----EQE 921

  Rat   795 LQAVESLCSAQHS--HVIE------------------------SNDLSEEKIRMKET---VEGLQ 830
            ||.::|..:...|  .|::                        .:::|:.|.:.:||   ::..|
  Fly   922 LQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQ 986

  Rat   831 DKLNKRDKEVAA--------------LTSQMDMLRAQVSALENKCKSGEKKIDSLLKEKRRLEAE 881
            ..|..:.|::.|              |..|:..|:::|...:....|....::|..|:.....|.
  Fly   987 SNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAA 1051

  Rat   882 LEAVSR---------------------------KTHDASGQLVHI-------------------- 899
            ||.|::                           :...:|...:|.                    
  Fly  1052 LEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKA 1116

  Rat   900 ---SQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 961
               |||:|:||:.|.|||..|.::..         |:...|||...||:..::.|:.|:|::|..
  Fly  1117 DAWSQEMLQKEKELQELRQQLQDSQD---------SQTKLKAEGERKEKSFEESIKNLQEEVTKA 1172

  Rat   962 DKEK-SLSEQKRYSLIDPASAPEL--LRLQH-QLVSTEDALRDALDQAQQVERLVEALRGCSDRT 1022
            ..|. .||...:.::.|.....|:  ..||| :.:::|||.:.|     .::.||||::..:   
  Fly  1173 KTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIA-----DLKTLVEAIQVAN--- 1229

  Rat  1023 QTISNSGSANG----IHQPDKAHKQEDKH 1047
               :|..:.|.    :.:..:|.|.|..|
  Fly  1230 ---ANISATNAELSTVLEVLQAEKSETNH 1255

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Clip2NP_068837.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..72 21/79 (27%)
CAP_GLY 82..146 CDD:396049 35/63 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 196..216 2/19 (11%)
CAP_GLY 222..286 CDD:396049 40/66 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 314..340 7/25 (28%)
Smc <357..1016 CDD:224117 182/895 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1047 5/28 (18%)
CLIP-190NP_001368962.1 PHA03307 <2..>118 CDD:223039 25/107 (23%)
CAP_GLY 125..189 CDD:396049 35/63 (56%)
CAP_GLY 239..306 CDD:396049 40/66 (61%)
SMC_prok_B <546..912 CDD:274008 80/382 (21%)
Smc 734..1591 CDD:224117 108/549 (20%)
SHE3 1502..1702 CDD:293683
CLIP1_ZNF 1773..1789 CDD:406934
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 191 1.000 Domainoid score I3141
eggNOG 1 0.900 - - E1_COG5244
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 346 1.000 Inparanoid score I2243
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1110101at2759
OrthoFinder 1 1.000 - - FOG0002895
OrthoInspector 1 1.000 - - otm44494
orthoMCL 1 0.900 - - OOG6_104816
Panther 1 1.100 - - O PTHR18916
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2251
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.830

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