DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tlr4 and Tl

DIOPT Version :9

Sequence 1:	NP_062051.2	Gene:	Tlr4 / 29260	RGDID:	3870	Length:	835	Species:	Rattus norvegicus
Sequence 2:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster

Alignment Length:	867	Identity:	210/867 - (24%)
Similarity:	333/867 - (38%)	Gaps:	233/867 - (26%)

- Green bases have known domain annotations that are detailed below.

  Rat     2 MPLLHLAGTLIMALF-----LSCLR--------PGSLNPCIEVLPNITYQCMDQNLSK------I 47
            :||    .||...||     |..||        ||.|   .|....||...:..||.|      :
  Fly   305 VPL----ATLPSRLFANQPELQILRLRAELQSLPGDL---FEHSTQITNISLGDNLLKTLPATLL 362

  Rat    48 PHDIPYSTKNLDLSFNPLKILRSYSFSNFSQLQWLDLSRCEIETIEDKAWHGLNQLSTLVLTGNP 112
            .|.:  :..:||||.|.|..|....|::.:.|..|.|....:..|....:..|..|.|||::.|.
  Fly   363 EHQV--NLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNR 425

  Rat   113 IKSFSPGSFSGLTNLENL---------------VAVETKMTSLEGFHIGQLISLKKLNVAHNLIH 162
            :::....:|.....|.:|               :.::|::.|..|:..|    |..||:.:|.|
  Fly   426 LRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHG----LLTLNLRNNSI- 485

  Rat   163 SFKLPEYFSNLTNLEHVDLSYNYIQTISVKDLQFLRENPQVNLSLDLSLNPIDSIQAQAFQGIRL 227
            .|...::.:.:..|..:|||||.|.::..:||.||.:|                         ||
  Fly   486 IFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQN-------------------------RL 525

  Rat   228 HELTLRSNFNSSNVLKMCLQNMTGLHVHRLILGEFKNERNLESFDRSVMEGLCNVSIDEFRLTYI 292
            |                  .|||...:.|:.|.|          |..:.||..|      .|.::
  Fly   526 H------------------VNMTHNKIRRIALPE----------DVHLGEGYNN------NLVHV 556

  Rat   293 NHFSDDIYNLNCLANISAMSFTGVHIKHIADVPRHFKWQSLSIIRCHLKPFPKLSLPFLKSWTLT 357
            : .:|:....:|..........|||....:   |.||.::..:: |        |.|.:...|..
  Fly   557 D-LNDNPLVCDCTILWFIQLVRGVHKPQYS---RQFKLRTDRLV-C--------SQPNVLEGTPV 608

  Rat   358 TNREDISFGQLALPSLRYLDLSRNAMSFRGC-CSYSDFGTNNLKYLDLSFNGVILMSANFMGLEE 421
            ...|.    |..:..|.:.|..|.....||| |...            :::..::::.:...|..
  Fly   609 RQIEP----QTLICPLDFSDDPRERKCPRGCNCHVR------------TYDKALVINCHSGNLTH 657

  Rat   422 LEYLDFQHSTLKKVTEFSVFLSLEKLLYLDISYTNTKIDFDGIFLGLISLNTLKMAGNSFKDNTL 486
            :..|...|..::.:.     |.||....|.:...||.        |..|:.:|.:|||:.   |.
  Fly   658 VPRLPNLHKNMQLME-----LHLENNTLLRLPSANTP--------GYESVTSLHLAGNNL---TS 706

  Rat   487 SNVFTNTTNLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQLYSLRTLDCSF 551
            .:|....||||.||:|              ...||:||
  Fly   707 IDVDQLPTNLTHLDIS--------------WNHLQMLN--------------------------- 730

  Rat   552 NRIETSKGILQHFPKSLAVFNLTNNSVACICEYQNFLQWVKDQKMFLVNVEQMKCASPIDMKASL 616
               .|..|.|....|..:| .|:.|...|.|..:..|.:.:|....:.:..:|.|.: .:|...:
  Fly   731 ---ATVLGFLNRTMKWRSV-KLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVN-AEMPTRM 790

  Rat   617 VLDFTNSTCYIYKTI-ISVSVV---SVLVVATVAFLIYHF--------YFHLILIAGCKKYSRGE 669
            |...||..|...|.: |:::||   :.|:....|.|.|.|        |.|.:|:    .:...|
  Fly   791 VELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLL----WFVTEE 851

  Rat   670 SI-----YDAFVIYSSQNEDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANIIQEGFHKSR 729
            .:     :|||:.||.:::.::.:.||..||.|..:||||:|.||::.|..|..||:: ....||
  Fly   852 DLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMR-SVADSR 915

  Rat   730 KVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIV---LEKVEKSLLRQQVELYRLLSRNT 791
            :.|:|:|::||:|.|...|:..|........||.||.|:   :..|||  |.::::.|  |..||
  Fly   916 RTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEK--LDEELKAY--LKMNT 976

  Rat   792 YLEWEDNALGRHIFWRRLKKAL 813
            ||:|     |...||.:|:.||
  Fly   977 YLKW-----GDPWFWDKLRFAL 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tlr4	NP_062051.2	PLN00113	23..>456	CDD:215061	94/454 (21%)
		LRR 1	54..75		8/20 (40%)
		leucine-rich repeat	58..78	CDD:275380	8/19 (42%)
		LRR 2	78..99		4/20 (20%)
		leucine-rich repeat	79..102	CDD:275380	5/22 (23%)
		LRR 3	102..123		6/20 (30%)
		leucine-rich repeat	103..126	CDD:275380	6/22 (27%)
		LRR 4	126..147		5/35 (14%)
		leucine-rich repeat	127..150	CDD:275380	6/37 (16%)
		LRR 5	150..171		6/20 (30%)
		leucine-rich repeat	151..175	CDD:275380	6/23 (26%)
		LRR 6	175..198		10/22 (45%)
		leucine-rich repeat	176..204	CDD:275380	12/27 (44%)
		LRR 7	204..224		0/19 (0%)
		leucine-rich repeat	205..226	CDD:275380	0/20 (0%)
		LRR 8	226..247		3/20 (15%)
		leucine-rich repeat	256..310	CDD:275380	10/53 (19%)
		LRR 9	372..381		2/8 (25%)
		leucine-rich repeat	373..398	CDD:275380	7/25 (28%)
		LRR 10	398..420		0/21 (0%)
		leucine-rich repeat	399..421	CDD:275380	1/21 (5%)
		LRR 11	421..442		2/20 (10%)
		leucine-rich repeat	422..446	CDD:275380	4/23 (17%)
		LRR 12	446..467		3/20 (15%)
		leucine-rich repeat	447..470	CDD:275380	4/22 (18%)
		LRR 13	470..491		7/20 (35%)
		leucine-rich repeat	471..495	CDD:275380	6/23 (26%)
		LRR_8	494..554	CDD:404697	11/59 (19%)
		LRR 14	495..516		6/20 (30%)
		leucine-rich repeat	496..519	CDD:275380	5/22 (23%)
		LRR 15	519..540		4/20 (20%)
		leucine-rich repeat	520..543	CDD:275380	4/22 (18%)
		LRR 16	543..564		3/20 (15%)
		leucine-rich repeat	544..567	CDD:275380	3/22 (14%)
		TIR	672..813	CDD:214587	52/143 (36%)
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..222	CDD:275380
		LRR_RI	216..542	CDD:238064	71/303 (23%)
		LRR_8	221..281	CDD:290566
		leucine-rich repeat	223..270	CDD:275380
		leucine-rich repeat	271..294	CDD:275380
		leucine-rich repeat	295..320	CDD:275380	6/18 (33%)
		leucine-rich repeat	321..343	CDD:275380	7/24 (29%)
		LRR_8	342..402	CDD:290566	17/61 (28%)
		leucine-rich repeat	344..367	CDD:275380	6/24 (25%)
		leucine-rich repeat	368..391	CDD:275380	8/22 (36%)
		LRR_8	390..450	CDD:290566	13/59 (22%)
		leucine-rich repeat	392..415	CDD:275380	5/22 (23%)
		leucine-rich repeat	416..439	CDD:275380	6/22 (27%)
		leucine-rich repeat	440..474	CDD:275380	5/33 (15%)
		leucine-rich repeat	475..498	CDD:275380	6/23 (26%)
		LRR_8	477..534	CDD:290566	23/100 (23%)
		leucine-rich repeat	499..520	CDD:275380	9/20 (45%)
		leucine-rich repeat	523..552	CDD:275380	14/87 (16%)
		LRRCT	561..619	CDD:214507	13/73 (18%)
		LRRNT	631..667	CDD:214470	7/47 (15%)
		leucine-rich repeat	664..693	CDD:275380	8/41 (20%)
		LRR_8	669..726	CDD:290566	21/86 (24%)
		leucine-rich repeat	694..715	CDD:275380	6/23 (26%)
		leucine-rich repeat	716..737	CDD:275380	11/64 (17%)
		LRRCT	751..800	CDD:214507	11/49 (22%)
		TIR	858..996	CDD:214587	54/146 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920