DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tlr4 and Toll-7

DIOPT Version :9

Sequence 1:NP_062051.2 Gene:Tlr4 / 29260 RGDID:3870 Length:835 Species:Rattus norvegicus
Sequence 2:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster


Alignment Length:1044 Identity:218/1044 - (20%)
Similarity:376/1044 - (36%) Gaps:350/1044 - (33%)


- Green bases have known domain annotations that are detailed below.


  Rat    58 LDLSFNPLK-ILRSYSFSNFSQLQWLDLSRCEIETIEDKAWHGLNQLSTLVLTGNPIKSFSPGSF 121
            ||.|.|.|: |..|:..|...:||.|:|:...:..:..:|..||..|..:.|:.|.:::...|.|
  Fly   252 LDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLF 316

  Rat   122 SG---------------------LTNLENLVAVETKMTSLEGFHIGQ-----LISLKKLNVAHNL 160
            :|                     ...||.|:.|:.....|...|:..     ||.|..||:|||.
  Fly   317 AGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNA 381

  Rat   161 I-----HSFKLPEYFSNLTNLEHVDLSYNYIQTISVKDLQFLRENPQVNL-SLDLSLNPIDSIQA 219
            :     .:|| ..||..:.||.:..:.:       ::|..||   |..|| :|:|:.|.:.::..
  Fly   382 LTRIDYRTFK-ELYFLQILNLRNNSIGH-------IEDNAFL---PLYNLHTLNLAENRLHTLDD 435

  Rat   220 QAFQGIR-LHELTLRSNF----------------------NSSNVLKMCLQNMTGLHVHRLILGE 261
            :.|.|:. |.:|||.:|.                      |..|.:...||::..|..  |.|| 
  Fly   436 KLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRT--LDLG- 497

  Rat   262 FKNERNLESFDRSVMEGLCNVSIDEFRLTYINHFSDDIYNLNCLANISAMSFTGVHIKHIADVPR 326
               |..:.:||....:.|       .:||.:....:.|.|:.              :....|:||
  Fly   498 ---ENQIRTFDNQSFKNL-------HQLTGLRLIDNQIGNIT--------------VGMFQDLPR 538

  Rat   327 HFKWQSLSIIRCHLKPFPKLSLPFLKSWTLTTNREDISF-----GQLA-LPSLRYLDLSRNAMSF 385
               ...|::.:..::...:.|  |.|::.|...|.|.:|     |..| |.||.:|:||.|.:.:
  Fly   539 ---LSVLNLAKNRIQSIERGS--FDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVW 598

  Rat   386 RGCCSYSDFGTNNLKYLDLSFNGVILMSANFMGLEE---LEYLDFQHSTLKKVTEFSVFLSLEKL 447
               ..|: |..:|||:||:..|.:..: .|:..|:|   ::.||..|:.:.::...|:..::| |
  Fly   599 ---FDYA-FIPSNLKWLDIHGNYIEAL-GNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIE-L 657

  Rat   448 LYLD------------ISYTN-TKIDFDGIFLGLISLNTLKMA--------------GNSFK-DN 484
            |:::            :...| .::|.....|..:.|..|::|              ||.|: |.
  Fly   658 LFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDC 722

  Rat   485 TL--------------------------------------------------------------- 486
            |:                                                               
  Fly   723 TMDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDF 787

  Rat   487 ----------------------------------------------------------SNVFTNT 493
                                                                      ::.|...
  Fly   788 DACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGR 852

  Rat   494 TNLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQLYSLRTLDCSFNRIETSK 558
            .||..|.::..|:..|....|.:|..||||:::.|.|..|....::||.:||.|....|::.|.:
  Fly   853 KNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIE 917

  Rat   559 G-----------------------ILQ----HFPKSLAVFNLTNNSVACICEY-QNFLQWVKDQK 595
            .                       |.|    ||...|...:|..|..:|.|:: |....:|.|..
  Fly   918 NATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNA 982

  Rat   596 MFLVNVEQMKC--ASPIDMKASL-------------VLDF--TNSTC-----------------Y 626
            :.:.:.:.:.|  ||.....|:|             .|||  |.:.|                 |
  Fly   983 LIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESY 1047

  Rat   627 IYKTIISVSVVSVLVVATVAFL------IYHFYFHLILIAG--CKKYSRGESIYDAFVIYSSQNE 683
            |.....:::::.:|||..:.|.      |:.|..:.:.:.|  |::   .|.:|||.:::|:::.
  Fly  1048 IPLLAAALALLFLLVVIAMVFAFRESLRIWLFAHYGVRVFGPRCEE---SEKLYDAVLLHSAKDS 1109

  Rat   684 DWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANIIQ--EGFHKSRKVIVVVSRHFIQSRWCI 746
            ::|...|...||.|.|..::||.:||    :|..|...|  |....||:|:::::|:|:|:.|..
  Fly  1110 EFVCQHLAAQLETGRPPLRVCLQHRD----LAHDATHYQLLEATRVSRRVVILLTRNFLQTEWAR 1170

  Rat   747 FEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTY--LEWEDNALGRHIFWRRL 809
            .|.. ......|..|...:.|:.|..........:||...|..:..  :...|    || ||.:|
  Fly  1171 CELR-RSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIRRSD----RH-FWEKL 1229

  Rat   810 KKAL 813
            :.||
  Fly  1230 RYAL 1233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tlr4NP_062051.2 PLN00113 23..>456 CDD:215061 111/474 (23%)
LRR 1 54..75 7/17 (41%)
leucine-rich repeat 58..78 CDD:275380 8/20 (40%)
LRR 2 78..99 5/20 (25%)
leucine-rich repeat 79..102 CDD:275380 7/22 (32%)
LRR 3 102..123 5/20 (25%)
leucine-rich repeat 103..126 CDD:275380 6/43 (14%)
LRR 4 126..147 6/20 (30%)
leucine-rich repeat 127..150 CDD:275380 7/27 (26%)
LRR 5 150..171 9/25 (36%)
leucine-rich repeat 151..175 CDD:275380 10/28 (36%)
LRR 6 175..198 4/22 (18%)
leucine-rich repeat 176..204 CDD:275380 5/27 (19%)
LRR 7 204..224 6/20 (30%)
leucine-rich repeat 205..226 CDD:275380 6/21 (29%)
LRR 8 226..247 7/43 (16%)
leucine-rich repeat 256..310 CDD:275380 11/53 (21%)
LRR 9 372..381 5/8 (63%)
leucine-rich repeat 373..398 CDD:275380 7/24 (29%)
LRR 10 398..420 7/21 (33%)
leucine-rich repeat 399..421 CDD:275380 7/21 (33%)
LRR 11 421..442 5/23 (22%)
leucine-rich repeat 422..446 CDD:275380 4/23 (17%)
LRR 12 446..467 4/33 (12%)
leucine-rich repeat 447..470 CDD:275380 5/35 (14%)
LRR 13 470..491 8/156 (5%)
leucine-rich repeat 471..495 CDD:275380 9/159 (6%)
LRR_8 494..554 CDD:404697 20/59 (34%)
LRR 14 495..516 6/20 (30%)
leucine-rich repeat 496..519 CDD:275380 6/22 (27%)
LRR 15 519..540 7/20 (35%)
leucine-rich repeat 520..543 CDD:275380 9/22 (41%)
LRR 16 543..564 7/47 (15%)
leucine-rich repeat 544..567 CDD:275380 9/49 (18%)
TIR 672..813 CDD:214587 39/144 (27%)
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566 4/6 (67%)
leucine-rich repeat 191..214 CDD:275380
leucine-rich repeat 215..248 CDD:275380
LRR_RI 247..501 CDD:238064 66/265 (25%)
LRR_8 247..308 CDD:290566 18/55 (33%)
leucine-rich repeat 249..273 CDD:275380 8/20 (40%)
leucine-rich repeat 274..297 CDD:275380 7/22 (32%)
LRR_8 297..356 CDD:290566 10/58 (17%)
leucine-rich repeat 298..321 CDD:275380 6/22 (27%)
leucine-rich repeat 322..345 CDD:275380 1/22 (5%)
LRR_8 345..406 CDD:290566 18/61 (30%)
leucine-rich repeat 346..371 CDD:275380 5/24 (21%)
leucine-rich repeat 372..395 CDD:275380 8/23 (35%)
leucine-rich repeat 396..419 CDD:275380 6/32 (19%)
LRR_8 419..478 CDD:290566 13/58 (22%)
leucine-rich repeat 420..443 CDD:275380 6/22 (27%)
leucine-rich repeat 444..467 CDD:275380 5/22 (23%)
LRR_RI 466..622 CDD:238064 44/192 (23%)
leucine-rich repeat 468..488 CDD:275380 4/19 (21%)
LRR_8 491..549 CDD:290566 16/87 (18%)
leucine-rich repeat 491..514 CDD:275380 8/35 (23%)
leucine-rich repeat 515..536 CDD:275380 4/34 (12%)
leucine-rich repeat 539..562 CDD:275380 4/24 (17%)
leucine-rich repeat 563..585 CDD:275380 7/21 (33%)
leucine-rich repeat 586..626 CDD:275380 14/44 (32%)
leucine-rich repeat 627..653 CDD:275380 6/25 (24%)
LRRCT 716..772 CDD:214507 4/55 (7%)
LRRNT 796..830 CDD:214470 0/33 (0%)
leucine-rich repeat 812..829 CDD:275380 0/16 (0%)
leucine-rich repeat 833..854 CDD:275380 1/20 (5%)
LRR_8 853..913 CDD:290566 20/59 (34%)
leucine-rich repeat 855..878 CDD:275380 6/22 (27%)
LRR_4 878..918 CDD:289563 14/39 (36%)
leucine-rich repeat 879..902 CDD:275380 9/22 (41%)
leucine-rich repeat 903..926 CDD:275380 5/22 (23%)
leucine-rich repeat 927..953 CDD:275380 4/25 (16%)
TIR 1098..1235 CDD:214587 41/146 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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