DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tlr4 and Tehao

DIOPT Version :9

Sequence 1:	NP_062051.2	Gene:	Tlr4 / 29260	RGDID:	3870	Length:	835	Species:	Rattus norvegicus
Sequence 2:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster

Alignment Length:	805	Identity:	197/805 - (24%)
Similarity:	301/805 - (37%)	Gaps:	236/805 - (29%)

- Green bases have known domain annotations that are detailed below.

  Rat    62 FNPLKILRSYSFSNFSQLQWLDLSRCEIETIEDKAWHGLNQLSTLVLTGNPIKSFSPGSFSGLTN 126
            |..:..|:.:.|  ||          .:..:::..:||.:.|..|.|:.|  .:..||:.....|
  Fly   156 FGSVPGLKKFKF--FS----------HVPELQESIFHGFDTLRDLHLSVN--VTTLPGNMLSTVN 206

  Rat   127 --LENLVAVETKMTSLEGFHIGQLISLKKLNVAHNLIHSFK------LPEYFSNLTNLEHVDLS- 182
              |:.|......:.|.....:.:|..|:.|::|  |||.|.      .|.:|.::||||.|.|:
  Fly   207 GTLKTLTIESPGIVSFGNPLLRELQQLRNLSLA--LIHPFHERDKQLQPHFFGSMTNLEEVRLAS 269

  Rat   183 ------------YNYIQTISVKDLQFLRENP------QVNL-SLDLSLNPIDSIQAQAFQGIRLH 228
                        .|.:|.|.:.....|.|.|      |||| :||||.|.|.::....|:|  |.
  Fly   270 ATSSVNRSMFKGTNKLQLIKMNGNDDLMELPGEIFLDQVNLKTLDLSCNAIVTLHEDVFKG--LG 332

  Rat   229 ELTL--RSNFNSSNVLKMCLQNMTGLHVHRLILGEFKNERNLESFDRSVMEGLCNVSIDEFRLTY 291
            .|||  .|....:|:.......:|.|:|.||      |:.:|.:...||.:       |...|.|
  Fly   333 NLTLLDLSKNRLTNLSSTIFAPLTSLNVLRL------NKNSLTAMSPSVFQ-------DVVSLNY 384

  Rat   292 INHFSDDIYNLNCLANISAMSFTGVHIKHIADVPRHFK---WQSLSIIRCHLKPFPKLSLPFLKS 353
            |...:...|....|.|..|:..|.       |....:|   ||      |.         |....
  Fly   385 IEMVNTQFYGATLLMNYEAVVCTN-------DEACQYKSAEWQ------CD---------PRCIC 427

  Rat   354 WTLTTNREDISFGQLAL----PSLRYL-DLSRNAMSFRGCCSYSDFGTNNLKYLDLSFNGVILMS 413
            |.      ..|.|.|.:    .||..| ||.|..:    ..:....|.|:|
  Fly   428 WV------QRSVGSLIVDCRGTSLEELPDLPRTTL----LSTVLKVGNNSL-------------- 468

  Rat   414 ANFMGLEELEYLDFQHSTLKKVTEFSVFLSLEKLLYLDISYTNTKIDFDGIFLGLISLNTLKMAG 478
                            ::|..|:|.|             .|.|.    .|:||...:|.:|. :|
  Fly   469 ----------------TSLPTVSEHS-------------GYANV----SGLFLSDNNLTSLG-SG 499

  Rat   479 NSFKDNTLSNVFTNTTNLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQLYS 543
            :...|           |||.||:         ||       .|:.::|...||||..
  Fly   500 DQLPD-----------NLTHLDV---------RG-------NQIQSLSDEFLLFLQE-------- 529

  Rat   544 LRTLDCSFNRIETSKGILQHFPKSLAVFNLTNNSVACICEYQNFLQWVKDQKMFLVNVEQMKCAS 608
                                 |.:....:|:.|.:.|.||..:.|.:|:.....:.::..:.|..
  Fly   530 ---------------------PNNTMTLSLSGNPITCGCESLSLLFFVRTNPQRVRDIADIVCTK 573

  Rat   609 PIDMKASLVLDFTNSTCYIYKTIISVSV---VSVLVVATVAFLIYHFYFHLILIAG--CKKYSRG 668
               .|.|.........|..|..:||..|   |.|:.:.||.:|::.....:.|...  |..:...
  Fly   574 ---QKKSFQQMEAFELCPSYVLLISCVVGGLVIVICLLTVFYLMFQQELKIWLYNNNLCLWWVSE 635

  Rat   669 ESI-----YDAFVIYSSQNEDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANIIQEGFHKS 728
            |.:     ||||:.||.::|:.: ::|:..||.|...|:||||.||::.|..|...|::. ...|
  Fly   636 EELDKDKTYDAFISYSHKDEELI-SKLLPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRT-VDDS 698

  Rat   729 RKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVE-----KSLLRQQVELYRLLS 788
            ::||:|:|:|||.|.|...|:.||........|..||.|:..::|     .|.||..::|
  Fly   699 KRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRELEHMNGIDSELRAYLKL----- 758

  Rat   789 RNTYLEWEDNALGRHIFWRRLKKAL 813
             ||||:|     |..:||.:|..|:
  Fly   759 -NTYLKW-----GDPLFWSKLYYAM 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tlr4	NP_062051.2	PLN00113	23..>456	CDD:215061	99/431 (23%)
		LRR 1	54..75		3/12 (25%)
		leucine-rich repeat	58..78	CDD:275380	4/15 (27%)
		LRR 2	78..99		0/20 (0%)
		leucine-rich repeat	79..102	CDD:275380	2/22 (9%)
		LRR 3	102..123		6/20 (30%)
		leucine-rich repeat	103..126	CDD:275380	6/22 (27%)
		LRR 4	126..147		4/22 (18%)
		leucine-rich repeat	127..150	CDD:275380	4/22 (18%)
		LRR 5	150..171		8/26 (31%)
		leucine-rich repeat	151..175	CDD:275380	9/29 (31%)
		LRR 6	175..198		8/35 (23%)
		leucine-rich repeat	176..204	CDD:275380	11/46 (24%)
		LRR 7	204..224		9/20 (45%)
		leucine-rich repeat	205..226	CDD:275380	9/21 (43%)
		LRR 8	226..247		6/22 (27%)
		leucine-rich repeat	256..310	CDD:275380	13/53 (25%)
		LRR 9	372..381		5/9 (56%)
		leucine-rich repeat	373..398	CDD:275380	6/25 (24%)
		LRR 10	398..420		1/21 (5%)
		leucine-rich repeat	399..421	CDD:275380	1/21 (5%)
		LRR 11	421..442		4/20 (20%)
		leucine-rich repeat	422..446	CDD:275380	4/23 (17%)
		LRR 12	446..467		4/20 (20%)
		leucine-rich repeat	447..470	CDD:275380	5/22 (23%)
		LRR 13	470..491		4/20 (20%)
		leucine-rich repeat	471..495	CDD:275380	4/23 (17%)
		LRR_8	494..554	CDD:404697	13/59 (22%)
		LRR 14	495..516		7/20 (35%)
		leucine-rich repeat	496..519	CDD:275380	6/22 (27%)
		LRR 15	519..540		6/20 (30%)
		leucine-rich repeat	520..543	CDD:275380	6/22 (27%)
		LRR 16	543..564		0/20 (0%)
		leucine-rich repeat	544..567	CDD:275380	1/22 (5%)
		TIR	672..813	CDD:214587	52/145 (36%)
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	6/23 (26%)
		leucine-rich repeat	209..232	CDD:275380	4/22 (18%)
		leucine-rich repeat	233..261	CDD:275380	9/29 (31%)
		LRR_RI	<261..370	CDD:238064	36/116 (31%)
		leucine-rich repeat	262..284	CDD:275380	4/21 (19%)
		leucine-rich repeat	285..309	CDD:275380	6/23 (26%)
		LRR_8	309..368	CDD:290566	22/66 (33%)
		leucine-rich repeat	310..333	CDD:275380	10/24 (42%)
		leucine-rich repeat	334..357	CDD:275380	5/22 (23%)
		leucine-rich repeat	358..381	CDD:275380	9/35 (26%)
		leucine-rich repeat	445..482	CDD:275380	13/83 (16%)
		LRR_8	459..516	CDD:290566	23/131 (18%)
		leucine-rich repeat	483..505	CDD:275380	7/37 (19%)
		LRR_4	486..521	CDD:289563	14/62 (23%)
		TIR	643..779	CDD:214587	53/148 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_116606
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820