DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GRSF1 and CG7879

DIOPT Version :9

Sequence 1:	NP_002083.4	Gene:	GRSF1 / 2926	HGNCID:	4610	Length:	480	Species:	Homo sapiens
Sequence 2:	NP_647626.1	Gene:	CG7879 / 38184	FlyBaseID:	FBgn0035235	Length:	985	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	95/491 - (19%)
Similarity:	172/491 - (35%)	Gaps:	109/491 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    59 AASQTRGLQTGPVPPGRLAGPPAVATSAAAAAAASYSAL---RASLLPQSLAAAAAVPTRSYSQE 120
            |..|.......|..|.:....| :|.::....|..|..|   :..||.|....|...||...|..
  Fly   279 ALQQVSSGSAAPAQPSKSESEP-IAFASVNPYAQMYPQLFQQQQMLLQQQQTQAKVSPTMGGSPG 342

Human   121 SKTTYLEDLPPPPEYELAPSKLEEEVDDVFLIRAQGLPWSCTMEDVLNFFSDCRIRNGENGIHFL 185
            ..:|                  .:.|.|...||..|:..:.:..|:..:|....|.:  |||..:
  Fly   343 GGST------------------PQVVADTCYIRMSGMCQNTSYSDIRKYFQGMYIPH--NGIKIM 387

Human   186 LNRDGKRRGDALIEMESEQDVQKALEKHRMYMGQRYVEVYEINNEDVDALMKSLQVKSS------ 244
            : .:|.|.|.|.:|.......|||::::......|.:::..:.:::.:...:....:..
  Fly   388 M-VNGSRTGVAYVEFSRVSSAQKAVQRNNTMFRDRLIQIVPVGDDEFEMAEERASRQGQDGSRSH 451

Human   245 ---------------------PVVNDGVVRLRGLPYSCNEKDIVDFF-AGLNIVDITFVMDYRGR 287
                                 ||.|  |:.:..||.:..|:||:..| |...:|||......:.|
  Fly   452 GNHNGGDRGERGGGAPVPVPRPVTN--VLYIEDLPQTTTEQDIMKMFSASYTVVDILLSPSPKNR 514

Human   288 RKTGEAYVQFEEPEMANQAL---LKHREEIGNRYIEIFPSRRNEVRTHVGSYKGKKIASFPTAKY 349
            |:: .|:|.|.....|:.||   .||  .||.|.:.:..|...:::.  ...|.::.......:.
  Fly   515 RES-VAFVLFAREAEADSALQDTSKH--YIGFRQLRVRSSSEEDMQN--AKEKQRRANEQLLKEE 574

Human   350 ITEPEMVF--------EEHEVNEDIQP--MTAFESEKEIELPKEVPEKLPEAADFGTTSSLH--- 401
            ..:.|.:.        ::.:.||:||.  ..|....::.| .::..:::....:|.:..|.:
  Fly   575 ADQREELLKDQQRRQKQQQQENENIQANRFAADPRRRQAE-DQQQQQQMNMGPNFNSNMSPNMMA 638

Human   402 -FVHMRGLPFQAN--AQDIINFFAPLKPVRITMEYSSSGKATG-------------------EAD 444
             ||:...:||...  .|:.:|.|    |..:...|:.:|.:.|                   :.|
  Fly   639 PFVNGGNMPFHMPPLQQNGVNNF----PFNMNNNYNYNGNSNGNGPNYPNDNGGAGVIQRPRQED 699

Human   445 VHFETHEDAVAAMLKD------RSHVHHRYIELFLN 474
            |....|....|....|      ..|:...:||...|
  Fly   700 VFVRVHNCEYATRANDLGELFSLEHLRIEHIEQLFN 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRSF1	NP_002083.4	RRM1_GRSF1	149..227	CDD:241174	18/77 (23%)
		RRM2_GRSF1	249..322	CDD:240949	24/76 (32%)
		RRM	307..>459	CDD:223796	32/189 (17%)
		RRM3_GRSF1	401..475	CDD:241177	20/105 (19%)
CG7879	NP_647626.1	RRM1_RBM12_like	2..75	CDD:240954
		RRM_hnRNPH_ESRPs_RBM12_like	355..425	CDD:240700	18/72 (25%)
		RRM	<364..551	CDD:223796	42/194 (22%)
		RRM_SF	478..549	CDD:240668	23/73 (32%)
		RRM_SF	702..773	CDD:240668	7/34 (21%)
		RRM_hnRNPH_ESRPs_RBM12_like	910..982	CDD:240700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910