Protein Alignment GRPR and AstA-R1

DIOPT Version :10

• Sequence 1: NP_005305.1
• Gene: GRPR / 2925
• HGNCID: 4609
• Length: 384
• Species: Homo sapiens
• Sequence 2: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Alignment Length: 368
• Identity: 104/368 - (28%)
• Similarity: 170/368 - (46%)
• Gaps: 45/368 - (12%)

Human    18 HCNISSHSADLPVNDDWSHPG--------ILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNV 74
            |.:.|.|:|    ||...:..        :..::|..:|:|...||:||..:|.:....:.||:.
  Fly    48 HTDHSDHNA----NDSMEYDAESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRST 108

Human    75 PNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRY 139
            .||.|.:||:.|:|.:|.|.|..|:.|:...|.||.:.||.:.::.:.:...||:||..:|.||:
  Fly   109 TNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRF 173

Human   140 KAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSD--LHPFHEE-------STNQTFIS 195
            .|:|.|:...:........|.....||..:..|||.|:...  ::.:|..       ||.:...|
  Fly   174 LAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACVFSTEEEIWS 238

Human   196 CAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRK 260
            ...:           .::.||..||.||::|...|..:...|.:||..        .|...||||
  Fly   239 LVGF-----------QVSFFLSSYVAPLTLICFLYMGMLARLWKSAPG--------CKPSAESRK 284

Human   261 ---RLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFAL 322
               |:.:.|:|.|..||.||||.|||.:.::.:.  ...|.|..:..|.:.::|:||||:||...
  Fly   285 GKRRVTRMVVVVVLAFAICWLPIHVILVLKALNL--YGGSHLSVIIQIISHVVAYTNSCINPILY 347

Human   323 YLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTN 365
            ..||.:|||.|...:.|..|..::.:....::|...|...::|
  Fly   348 AFLSDNFRKAFRKVVWCGSPPPLMTNQQVTKTTRTATGNGTSN 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRPR	NP_005305.1	7tmA_GRPR	41..333	CDD:320252	92/303 (30%)
		TM helix 1	42..68	CDD:320252	8/25 (32%)
		TM helix 2	75..101	CDD:320252	11/25 (44%)
		TM helix 3	113..143	CDD:320252	10/29 (34%)
		TM helix 4	155..175	CDD:320252	5/19 (26%)
		TM helix 5	207..232	CDD:320252	8/24 (33%)
		TM helix 6	257..287	CDD:320252	17/32 (53%)
		TM helix 7	301..326	CDD:320252	8/24 (33%)
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	92/303 (30%)
		TM helix 1	76..102	CDD:320224	8/25 (32%)
		TM helix 2	109..135	CDD:320224	11/25 (44%)
		TM helix 3	147..177	CDD:320224	10/29 (34%)
		TM helix 4	189..209	CDD:320224	5/19 (26%)
		TM helix 5	239..268	CDD:320224	8/39 (21%)
		TM helix 6	284..314	CDD:320224	14/29 (48%)
		TM helix 7	326..351	CDD:320224	8/24 (33%)