Protein Alignment GRPR and TkR99D

DIOPT Version :10

• Sequence 1: NP_005305.1
• Gene: GRPR / 2925
• HGNCID: 4609
• Length: 384
• Species: Homo sapiens
• Sequence 2: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 451
• Identity: 115/451 - (25%)
• Similarity: 182/451 - (40%)
• Gaps: 122/451 - (27%)

Human     9 LNLEVDHFMHCNISSHSADLPVNDD-----------WSHPGILYVIP--------AVYGVIILIG 54
            |.|....|.|.  .:.|.|||...|           .......:|:|        .::|.::::.
  Fly    53 LALSTSSFNHS--QTLSTDLPAVGDVEDAAEDAAASMETGSFAFVVPWWRQVLWSILFGGMVIVA 115

Human    55 LIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRY--LADRWLFGRIGCKLIP 117
            ..||:.::.|..|.|.||.|.|.||.:|::.|  .:::...|..:.|  |...|.||...|||..
  Fly   116 TGGNLIVVWIVMTTKRMRTVTNYFIVNLSIAD--AMVSSLNVTFNYYYMLDSDWPFGEFYCKLSQ 178

Human   118 FIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKIC--LKAAFIWIISMLLAIPEAVFSD 180
            ||.:.|:..|||||.|:|.|||.||:||:..:.|    |.|  ..||.||:.|.|::.|..:.
  Fly   179 FIAMLSICASVFTLMAISIDRYVAIIRPLQPRMS----KRCNLAIAAVIWLASTLISCPMMII-- 237

Human   181 LHPFHEES------TNQTFISCAP-YPHSNELHPKIHSMASFLVF---YVIPLSIISVYYYFIAK 235
               :..|.      :|:|.  |.| :|.....|..:.|:.:.|:.   |.:|:..::|.|
  Fly   238 ---YRTEEVPVRGLSNRTV--CYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSMTVTY----- 292

Human   236 NLIQSAYNLPVEGNIHV----KKQIE---SRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSE 293
                |...:.:.|:..:    .:|:|   |::|:.|.::|.|.:||.||||.|..::..|.:.:.
  Fly   293 ----SRVGIELWGSKTIGECTPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYPAI 353

Human   294 VDTSMLHFVTSICARL--LAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIR--------- 347
            .:..   |:..:...:  ||.:||..||.....::..||..|......|   |.:|
  Fly   354 TEAP---FIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWC---LFVRVGTEPFSRR 412

Human   348 ----------------------------------------SHS-TGRSTTCMTSLKSTNPS 367
                                                    ||| ||||.|...||.:.:.|
  Fly   413 ENLTSRYSCSGSPDHNRIKRNDTQKSILYTCPSSPKSHRISHSGTGRSATLRNSLPAESLS 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRPR	NP_005305.1	7tmA_GRPR	41..333	CDD:320252	91/322 (28%)
		TM helix 1	42..68	CDD:320252	6/33 (18%)
		TM helix 2	75..101	CDD:320252	6/25 (24%)
		TM helix 3	113..143	CDD:320252	17/29 (59%)
		TM helix 4	155..175	CDD:320252	8/21 (38%)
		TM helix 5	207..232	CDD:320252	6/27 (22%)
		TM helix 6	257..287	CDD:320252	13/32 (41%)
		TM helix 7	301..326	CDD:320252	7/26 (27%)
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	89/314 (28%)
		TM helix 1	103..129	CDD:320512	4/25 (16%)
		TM helix 2	136..162	CDD:320512	7/27 (26%)
		TM helix 3	174..204	CDD:320512	17/29 (59%)
		TM helix 4	215..236	CDD:320512	8/20 (40%)
		TM helix 5	269..298	CDD:320512	7/37 (19%)
		TM helix 6	317..347	CDD:320512	12/29 (41%)
		TM helix 7	360..385	CDD:320512	6/24 (25%)