Protein Alignment GRPR and TkR86C

DIOPT Version :10

• Sequence 1: NP_005305.1
• Gene: GRPR / 2925
• HGNCID: 4609
• Length: 384
• Species: Homo sapiens
• Sequence 2: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Alignment Length: 385
• Identity: 106/385 - (27%)
• Similarity: 182/385 - (47%)
• Gaps: 46/385 - (11%)

Human     9 LNLEVDHFMHCNISSHSA--DLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSM 71
            :|...|....|...|.:.  :||    |....|..:|   :|:::.:.:.||..::.|....:||
  Fly    57 INEAKDFLTECLFPSPTRPYELP----WEQKTIWAII---FGLMMFVAIAGNGIVLWIVTGHRSM 114

Human    72 RNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSA 136
            |.|.|.|:.:|::.|||:.......:....|...|.||.|.|.:..|:...:|..|||||.|:|.
  Fly   115 RTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISF 179

Human   137 DRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDL---HPFHEESTNQTFISCAP 198
            |||.|||.|:..:.|...::|.|  ..||.:|.:|:.|..::|.:   |.::.:|....|:....
  Fly   180 DRYIAIVHPLKRRTSRRKVRIIL--VLIWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPD 242

Human   199 YPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNI--HVKKQIESRKR 261
            ..:...:....:::...::.|.||:.::.:.|..:.:.|..|.       :|  :..:|:||.|.
  Fly   243 GRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLWGSR-------SIGENTDRQMESMKS 300

Human   262 LAKTVLVF---VGLFAFCWLPNHVIYLYRSYHYSEVDTS--MLHFVTSICARLLAFTNSCVNPFA 321
            ..|.|.:|   |.:||.||||.|:.::| :||.::|.::  :.|.....  ..||.:|:.|||..
  Fly   301 KRKVVRMFIAIVSIFAICWLPYHLFFIY-AYHNNQVASTKYVQHMYLGF--YWLAMSNAMVNPLI 362

Human   322 LYLLSKSFRKQFNTQLLCCQPGL-----------IIRSHSTGRST----TCMTSLKSTNP 366
            .|.::|.||..|...:.||..||           :...:|:.|.|    |...||.:::|
  Fly   363 YYWMNKRFRMYFQRIICCCCVGLTRHRFDSPKSRLTNKNSSNRHTRGGYTVAHSLPNSSP 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRPR	NP_005305.1	7tmA_GRPR	41..333	CDD:320252	86/301 (29%)
		TM helix 1	42..68	CDD:320252	5/25 (20%)
		TM helix 2	75..101	CDD:320252	6/25 (24%)
		TM helix 3	113..143	CDD:320252	14/29 (48%)
		TM helix 4	155..175	CDD:320252	6/19 (32%)
		TM helix 5	207..232	CDD:320252	4/24 (17%)
		TM helix 6	257..287	CDD:320252	14/32 (44%)
		TM helix 7	301..326	CDD:320252	7/24 (29%)
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	87/304 (29%)
		TM helix 1	85..111	CDD:320512	6/28 (21%)
		TM helix 2	118..144	CDD:320512	6/25 (24%)
		TM helix 3	156..186	CDD:320512	14/29 (48%)
		TM helix 4	197..218	CDD:320512	7/22 (32%)
		TM helix 5	251..280	CDD:320512	4/28 (14%)
		TM helix 6	299..329	CDD:320512	13/30 (43%)
		TM helix 7	342..367	CDD:320512	8/26 (31%)