Protein Alignment GRPR and sNPF-R

DIOPT Version :10

• Sequence 1: NP_005305.1
• Gene: GRPR / 2925
• HGNCID: 4609
• Length: 384
• Species: Homo sapiens
• Sequence 2: NP_524176.1
• Gene: sNPF-R / 40195
• FlyBaseID: FBgn0036934
• Length: 600
• Species: Drosophila melanogaster
• Alignment Length: 411
• Identity: 101/411 - (24%)
• Similarity: 176/411 - (42%)
• Gaps: 99/411 - (24%)

Human    26 ADLPVNDDWSHPGIL---------YVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISS 81
            ||:..:|:....||:         ||:   |..:.::|:.||:.:..:....::|:.|.|:||::
  Fly    43 ADVAASDEDRSGGIIHNQFVQIFFYVL---YATVFVLGVFGNVLVCYVVLRNRAMQTVTNIFITN 104

Human    82 LALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPM 146
            |||.|:||.:...|.........||.|||..|.|:.|.|..|:.:|..|||:::.|||..|:.|.
  Fly   105 LALSDILLCVLAVPFTPLYTFMGRWAFGRSLCHLVSFAQGCSIYISTLTLTSIAIDRYFVIIYPF 169

Human   147 DIQASHALMKI--CLK-AAFIWIISMLLAIPEAVFSDLHPFHE-----ESTNQTFISCA------ 197
                 |..||:  |:. ...||:|::|..:|..::..:  .:|     ::.|:|.:...
  Fly   170 -----HPRMKLSTCIGIIVSIWVIALLATVPYGMYMKM--TNELVNGTQTGNETLVEATLMLNGS 227

Human   198 ----------------------------------PYPH-------SNELHPKIHSMASFLVFYVI 221
                                              ||..       .:|.:.|:....:..:.:|:
  Fly   228 FVAQGSGFIEAPDSTSATQAYMQVMTAGSTGPEMPYVRVYCEENWPSEQYRKVFGAITTTLQFVL 292

Human   222 PLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESR---KRLAKTVLVFVGLFAFCWLPNHVI 283
            |..|||:.|.:|:..|.|.|...|  |:...:::...|   ||..:.::..|.:|...|||.:|:
  Fly   293 PFFIISICYVWISVKLNQRARAKP--GSKSSRREEADRDRKKRTNRMLIAMVAVFGLSWLPINVV 355

Human   284 YLYRSYHYSEVDTS-------MLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQ 341
            .::..:.    |.|       :..||    |..:|.:::|.|||....|:::|||:|...|.|..
  Fly   356 NIFDDFD----DKSNEWRFYILFFFV----AHSIAMSSTCYNPFLYAWLNENFRKEFKHVLPCFN 412

Human   342 PG-----LIIRSHSTGRSTTC 357
            |.     .|.|.::.....||
  Fly   413 PSNNNIINITRGYNRSDRNTC 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRPR	NP_005305.1	7tmA_GRPR	41..333	CDD:320252	88/356 (25%)
		TM helix 1	42..68	CDD:320252	5/25 (20%)
		TM helix 2	75..101	CDD:320252	10/25 (40%)
		TM helix 3	113..143	CDD:320252	12/29 (41%)
		TM helix 4	155..175	CDD:320252	7/22 (32%)
		TM helix 5	207..232	CDD:320252	7/24 (29%)
		TM helix 6	257..287	CDD:320252	9/32 (28%)
		TM helix 7	301..326	CDD:320252	8/24 (33%)
sNPF-R	NP_524176.1	7tmA_NPYR-like	64..404	CDD:320331	88/359 (25%)
		TM helix 1	65..91	CDD:320331	6/28 (21%)
		TM helix 2	98..123	CDD:320331	10/24 (42%)
		TM helix 3	136..166	CDD:320331	12/29 (41%)
		TM helix 4	177..198	CDD:320331	6/20 (30%)
		TM helix 5	278..307	CDD:320331	8/28 (29%)
		TM helix 6	329..359	CDD:320331	8/29 (28%)
		TM helix 7	372..397	CDD:320331	8/28 (29%)