Protein Alignment GRPR and AstC-R2

DIOPT Version :10

• Sequence 1: NP_005305.1
• Gene: GRPR / 2925
• HGNCID: 4609
• Length: 384
• Species: Homo sapiens
• Sequence 2: NP_001303398.1
• Gene: AstC-R2 / 40019
• FlyBaseID: FBgn0036789
• Length: 593
• Species: Drosophila melanogaster
• Alignment Length: 341
• Identity: 91/341 - (26%)
• Similarity: 154/341 - (45%)
• Gaps: 32/341 - (9%)

Human    13 VDHFMHCNISSHSADLPVNDD-----WSHPGILYVIPAV-YGVIILIGLIGNITLIKIFCTVKSM 71
            :||.......:.|..|..:||     :|:..||.:|..: |.::.:|||.||..:|.:......|
  Fly   112 LDHRNRPTQQNGSHYLEYDDDGPDCSYSYNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKM 176

Human    72 RNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCK-LIPFIQLTSVGVSVFTLTALS 135
            :.|.|::|.:||:.|...||. .|..........|.||...|| .:....:||...|:| |..:|
  Fly   177 QTVTNIYILNLAIADECFLIG-IPFLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIF-LLIMS 239

Human   136 ADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISC-APY 199
            ||||.|:..|:............|.:||.|:.|:||.:|..:|:..    .:|:|.. :|| ..:
  Fly   240 ADRYIAVCHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPVILFAST----VQSSNGN-VSCNIEW 299

Human   200 PHSNELHPKIHSMASFLVF-----YVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIE-S 258
            |.:.    ..|:.::|:::     :..||:.|.|:|..:.:       .|...|..|..|:.: |
  Fly   300 PDTQ----NSHTDSTFILYSLVLGFATPLTFILVFYCLVIR-------KLHTVGPKHKSKEKKRS 353

Human   259 RKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALY 323
            .:::.|.||..:..:.|||||:.:..:.......:...|.|.....:....|:::||.:||....
  Fly   354 HRKVTKLVLTVISAYIFCWLPHWISQVALISSAPQRCASRLELAVFLACGCLSYSNSAMNPILYA 418

Human   324 LLSKSFRKQFNTQLLC 339
            .||.:|:|.|.....|
  Fly   419 FLSDNFKKSFMKACTC 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRPR	NP_005305.1	7tmA_GRPR	41..333	CDD:320252	80/300 (27%)
		TM helix 1	42..68	CDD:320252	8/26 (31%)
		TM helix 2	75..101	CDD:320252	8/25 (32%)
		TM helix 3	113..143	CDD:320252	13/30 (43%)
		TM helix 4	155..175	CDD:320252	7/19 (37%)
		TM helix 5	207..232	CDD:320252	7/29 (24%)
		TM helix 6	257..287	CDD:320252	9/30 (30%)
		TM helix 7	301..326	CDD:320252	5/24 (21%)
AstC-R2	NP_001303398.1	7tmA_AstC_insect	146..428	CDD:320222	80/299 (27%)
		TM helix 1	147..173	CDD:320222	8/25 (32%)
		TM helix 2	180..206	CDD:320222	8/26 (31%)
		TM helix 3	217..247	CDD:320222	13/30 (43%)
		TM helix 4	259..281	CDD:320222	8/21 (38%)
		TM helix 5	308..337	CDD:320222	6/35 (17%)
		TM helix 6	352..382	CDD:320222	9/29 (31%)
		TM helix 7	396..421	CDD:320222	5/24 (21%)