Protein Alignment GRPR and CCKLR-17D1

DIOPT Version :10

• Sequence 1: NP_005305.1
• Gene: GRPR / 2925
• HGNCID: 4609
• Length: 384
• Species: Homo sapiens
• Sequence 2: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Alignment Length: 531
• Identity: 118/531 - (22%)
• Similarity: 175/531 - (32%)
• Gaps: 220/531 - (41%)

Human    25 SADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLL 89
            |||:|:          :|:|. |..|:|..::||:.::......:.||.:.|:|:.:||:.|:||
  Fly   171 SADVPI----------WVVPC-YSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILL 224

Human    90 LITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQA---- 150
            .:.|.||.....|...::||.:.||||.|.|..||.||.:||.|:|.:||.||..|:..:.
  Fly   225 GVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTI 289

Human   151 SHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISC-APYPHSNELHPKIHSMAS 214
            :||...|    |.||:.|::...|.|.||.|.|    ::......| ..:|..:..:.:.:::..
  Fly   290 NHANKII----AIIWLGSLVCMTPIAAFSQLMP----TSRPGLRKCREQWPADSLNYERAYNLFL 346

Human   215 FLVFYVIPLSIISVYYYFIAKNLIQSAYNL----------------------------------- 244
            .|...|:||..:|..|.||.:.|..|..|.
  Fly   347 DLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQ 411

Human   245 ----------------------------------------PVEGNIHV----------------- 252
                                                    |.||..|:
  Fly   412 SLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQIN 476

Human   253 --------------------------------------------------------------KKQ 255
                                                                          .|.
  Fly   477 GGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKS 541

Human   256 IESRKRLAKTVLVFVGLFAFCWLPNHVI-----------YLYRSYHYSEVDTSMLHFVTSIC-AR 308
            :||:||:.|.:.|.|..|..||.|.:||           |.|..|             |||. .:
  Fly   542 LESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVGY-------------TSISFLQ 593

Human   309 LLAFTNSCVNPFALYLLSKSFRK----QFNTQLLC---CQPGLIIRSHSTGRSTTCMTSLKSTNP 366
            |||:::||.||.....::.|||:    .|....:|   |.|....|..|.          ..||.
  Fly   594 LLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPCCFWRRRSK----------NETNL 648

Human   367 SVATFSLINGN 377
            |||..|:...|
  Fly   649 SVAGNSIALAN 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRPR	NP_005305.1	7tmA_GRPR	41..333	CDD:320252	101/466 (22%)
		TM helix 1	42..68	CDD:320252	7/25 (28%)
		TM helix 2	75..101	CDD:320252	10/25 (40%)
		TM helix 3	113..143	CDD:320252	17/29 (59%)
		TM helix 4	155..175	CDD:320252	5/19 (26%)
		TM helix 5	207..232	CDD:320252	6/24 (25%)
		TM helix 6	257..287	CDD:320252	14/40 (35%)
		TM helix 7	301..326	CDD:320252	10/25 (40%)
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	101/462 (22%)
		TM helix 1	178..202	CDD:410628	7/24 (29%)
		TM helix 2	211..233	CDD:410628	10/21 (48%)
		TM helix 3	249..271	CDD:410628	12/21 (57%)
		TM helix 4	294..310	CDD:410628	5/19 (26%)
		TM helix 5	340..363	CDD:410628	5/22 (23%)
		TM helix 6	549..571	CDD:410628	9/21 (43%)
		TM helix 7	586..611	CDD:410628	11/37 (30%)