DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp2 and yl

DIOPT Version :9

Sequence 1:XP_038960355.1 Gene:Lrp2 / 29216 RGDID:68407 Length:4665 Species:Rattus norvegicus
Sequence 2:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster


Alignment Length:2049 Identity:555/2049 - (27%)
Similarity:867/2049 - (42%) Gaps:379/2049 - (18%)


- Green bases have known domain annotations that are detailed below.


  Rat    12 LLLAIAAC-----LEPVSSQ-ECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGCPPRSCESG 70
            |||.:..|     ..|.|:. .|.:|.|:|.:|.||..:..|||..||.|.:||:.|..|.|.  
  Fly    68 LLLLVGLCGGTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCR-- 130

  Rat    71 LFLCPAEGTCIPSSWVCDEDKDCSDGADEQQNCAGTTCSAQQMTCSNGQCIPSEYRCDHVSDCPD 135
                       |..|.               .||.          .:|.|:.:|..|:.:.:||.
  Fly   131 -----------PPHWF---------------PCAQ----------PHGACLAAELMCNGIDNCPG 159

  Rat   136 GSDERNCHYPTCDQLTCANGACYNTSQRCDQKVDCRDSSDEANCTTLCSQKEFECGSGE-CILRA 199
            |.||.||        ....|..:               .|.|:....||:.||.|.... ||...
  Fly   160 GEDELNC--------PVRPGFRF---------------GDTAHRMRSCSKYEFMCQQDRTCIPID 201

  Rat   200 YVCDHDNDCEDNSDE-RNCNYD--TCGGHQFTCSNGQCI-NQNWVCDGDDDCQDSGDEDGCESNQ 260
            ::||...||.|.||| ..|...  ||.|....|:||:|: .:.|||||.|||.|..||.||    
  Fly   202 FMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGC---- 262

  Rat   261 SHHRCYPR--EWACPGSGRCISIDKVCDGVPDCPEGDDENNV------TSGRTCGMGVCSVLNCE 317
             .:.|.|:  ::.|.....|:::.:||||..||.:|.||.::      ...:.|.:|.       
  Fly   263 -LNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKPDCDAKKCALGA------- 319

  Rat   318 YQCHQTP-FGGECFCPPGHIINSNDSRTCIDFDDCQIW-GICDQKCENRQGRHQCLCEEGYILER 380
             :||..| .|.|||||.|..:...:.: |.|.|:|:.. .:|.|.|||..|.::|:|:.||:|::
  Fly   320 -KCHMMPASGAECFCPKGFRLAKFEDK-CEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDK 382

  Rat   381 GQHCKSSDSFSAASVIFSNGR---------DLLVGDLHGR--NFR--ILAESKNRGMVMGVDFHY 432
                   |:.:..:|::.:..         .:.:..:|.|  |.|  :...:.|...|:||  .|
  Fly   383 -------DNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSKVIGV--AY 438

  Rat   433 QKHRVFWTDPMQ--EKVFSTDINGLNTQEILNVSVDTPENLAVDWINNKLYLVETKVNRIDVVNL 495
            ....::||:...  |.:...:.:|.|.:.:|...:|.||:|||||:...:|..:..:..|.|.:.
  Fly   439 DGSHIYWTNIQNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSN 503

  Rat   496 EGNQRVTLITENLGHPRGIALDPTVGYLFFSDWGSLSGQPKVERAFMDGSNRKDLVTTKVGWPAG 560
            :|.....|:|:::..||.:|:.|..|.:|::|||.   :|.:.||.||||..:.:|:..:.||.|
  Fly   504 DGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGE---KPMIGRASMDGSRSRPIVSDNIEWPNG 565

  Rat   561 ITLDLVSKRVYWVDSRYDYIETVTYDGIQRKTVARGGSLVPHPFGISLFEEHVFFTDWTKMAVMK 625
            |.||:..:|:||||::...::||..||..|:||..|  ::.||:|:::||:.::::||...:|..
  Fly   566 IALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSDWATKSVHA 628

  Rat   626 ASKFTETNPQVYHQSSLRPHGVTVYHALRQPNATNPCGSNNGGCAQVCVLSHRTDNGGLGYRCKC 690
            ..||:..:.::..:.. ..:.|.:||..:|||  :|.|..|..|:.:|:|: ..:.|  |:.|.|
  Fly   629 CHKFSGKDHRILAKDR-TIYAVHIYHPAKQPN--SPHGCENATCSHLCLLA-EPEIG--GHSCAC 687

  Rat   691 EFGFELDDDEHRCVAV--KNFLLFSSKTAVRGIPFTLSTQEDVMVPVTGSPSFFVGIDFDAQHST 753
            ..|..|..|..||:.:  :..|.......:..|..|...:..|....| .|.....:.::..:.:
  Fly   688 PDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYT-LPCLINEMVYNRINGS 751

  Rat   754 VFYSDLSKDIIYKQKIDGTGKEVITANRLESVECLTFDWISRNLYWTDGGLKSVTVLRLADKSRR 818
            :..:|..:.:|.:.:.:.....|:..:.|.:|..|.||.:||||||.|.....:.||.|..:.|.
  Fly   752 LIIADNDQRLILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRA 816

  Rat   819 QI--ISNLNNPRSIVVHPTAGYMFLSDWFRPAKIMRAWSDGSHL-----------MPIVNTSLGW 870
            .|  ......|..:.|.|..||:::        :::| ...||:           :.:....||.
  Fly   817 LIRFFPGQEVPIGLTVMPAEGYLYV--------VLKA-KRHSHIDKIPLSGKGEQVHVFEDDLGD 872

  Rat   871 PN-GLAIDWSASRLYWVDAFFDKIEHSTLDGLDRKRLGHVD----QMTHPFGLTVFKDNVFITDW 930
            .: .|..|:....::|.|:...:|.:|..      |:.|..    ::..|:.|.:...::|..:.
  Fly   873 DDIKLVTDYETQTIFWSDSDLGRISYSNY------RVPHSQIFRGKLRRPYSLAMVHHDLFWNEL 931

  Rat   931 RLGAIIRVRKSDGGDMTVI-------RRGISSVMHVKAYDADLQTGSNYCSQTTH----ANGDCS 984
            ....|....||:.|...||       ...|...:.|...:......|:...|.:|    .||.||
  Fly   932 GTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQESHPCQQQNGGCS 996

  Rat   985 HFCFPVPNFQRVCGCPYGMKLQRD--QMTCEGDPAREPPTQQCGSLSFPCNNGKCVPSFFRCDGV 1047
            |.|.....:..:|.||.|. :.||  ..||          .:.....|.|::|:|:....||:|.
  Fly   997 HICVGEGPYHSICLCPAGF-VYRDAGNRTC----------VEALDCEFRCHSGECLTMNHRCNGR 1050

  Rat  1048 DDCHDNSDEHQCGVFNN-----TCSPSAFACVRGGQCIPGQWHCDRQNDCLDGSDEQNCPTHATS 1107
            .||.|||||..|...:.     .|||:.|||..|.||:..:..||.:.||.|.||||:|.....|
  Fly  1051 RDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEKFDKS 1115

  Rat  1108 STCPSTSFTCDNHVCIPKDWVCDTDNDCSDGSDEKNCQASGTCQPTQFRCPDHRCISPLYVCDGD 1172
            ..|......|||..|:....|||..|||.|.|||..|:|:..|:|..|:|....||:..:.|||.
  Fly  1116 KKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSRCEPGMFQCGSGSCIAGSWECDGR 1180

  Rat  1173 KDCADGSDEAG-CV-LNCTSAQFKCADGSSCINSRYRCDGVYDCRDNSDEAGCPTRPPGM---CH 1232
            .||:|||||.. || .:|.....:|..| .|::....|||..||.|.|||..|.|....|   |.
  Fly  1181 IDCSDGSDEHDKCVHRSCPPDMQRCLLG-QCLDRSLVCDGHNDCGDKSDELNCGTDSSTMNISCA 1244

  Rat  1233 LDEFQCQGD-GTCIPNTWECDGHPDCIHGSDEHTGCVPKTCSPTHFLCDNG-NCIYKAWICDGDN 1295
            .|::||..: ..|:|:|..|:|..:|..|.|| ..| ...||...|.|.:| .||.:.:.|||..
  Fly  1245 EDQYQCTSNLKICLPSTVRCNGTTECPRGEDE-ADC-GDVCSIYEFKCRSGRECIRREFRCDGQK 1307

  Rat  1296 DCRDMSDEKDCPTQPFHCPSTQ---WQCPGYS-----------TCINLSALCDGVFDCPNGTDES 1346
            ||.|.|||..|..:..|...:|   |.....|           .|::||.:|:...||.||.||.
  Fly  1308 DCGDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSRVCNNFPDCTNGHDEG 1372

  Rat  1347 PLCNEPQQDQDSCSHFNGG--CTHQCMQGPFGATCLCPLGYQLANDTKTCEDINECDIPGFCSQH 1409
            |.|      ..:|...:|.  |.|:|...|.||.|.|..||:|..|.|:|.||:||.....|:|.
  Fly  1373 PKC------ATACRSASGRQVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQPCAQL 1431

  Rat  1410 CVNMRGSFRCACDPEYTLESDGRTCK--VTG--------------SENPLLV----VASRDKIIV 1454
            |.|..|.::|.|..::.|..|..:||  .:|              ||.|:::    .|:..:|..
  Fly  1432 CENTLGGYQCQCHADFMLRQDRVSCKSLQSGATLLFSSFNEVRNLSEQPVMLNVAWSANDSRITG 1496

  Rat  1455 DNITAHTHNLYSLVQDVSFVVALDFDSVTGRVFWSDLLQGKTWSVFQNGTDKRVVHDSGLSVTEM 1519
            .::..|....|...:|...|..:|..:                        |.:|...||.....
  Fly  1497 FDLAMHRQMGYFSAEDEGIVYQIDLQT------------------------KVIVRALGLPAPTK 1537

  Rat  1520 IAVDWIGRNLYWTDYALETIEVSKIDGSHRTVLISKNVTKPRGLALDPRMGDNVMFWSDWGHHPR 1584
            ::|||:..|:|....|.|....|.:......::..|:....:.||:|             |:|.|
  Fly  1538 LSVDWVTGNVYVLSGAQEIQACSFVGRMCGRIVHVKSPRHVKHLAVD-------------GYHAR 1589

  Rat  1585 -----------------IERASMDGTMRTVIVQEKIYWPCGLSIDYPNRLIYFMDAYLDYIEFCD 1632
                             |..|.:||:.|.:::|....:...|:.|...:|:||:|.::..:|...
  Fly  1590 IFYIVIRTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRTLERIS 1654

  Rat  1633 Y---DGHNRRQ--VIASDLVLHHPHALTLFEDFVYWTDRGTRQVMQANKWHGGNQSVVMYSVHQP 1692
            |   .|..||.  ::.....|.||..|:::|:..:..:.|:.:.:|...:.......:..:|...
  Fly  1655 YRLKTGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLGSVEAVQCALYGSRICHKISINVLNA 1719

  Rat  1693 LGITAIHPSRQP-PSRNPCASASCSHLCLLSAQAPRHYSCACPSGWNLSDDSVNCVRGDQPFLMS 1756
            ..|.....|||| .:.:|||.|.|..|||   ||...|.|.|  |..|..:...|          
  Fly  1720 QDIVVAGRSRQPQKASHPCAHAHCHGLCL---QADYGYECMC--GNRLVAEGERC---------- 1769

  Rat  1757 VRDNIIFGISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGEIHRVKTDGSNRTVFA 1821
                        |....|:  |.:.|..:..::|                 |..:.:|....:.|
  Fly  1770 ------------PHGSGNE--VAVLGAVNSLELE-----------------HEHEQNGHFHWLMA 1803

  Rat  1822 PLSLLGSSLGLALDW------------VSRNIYYTTPASRSIEVLTLKGDTRYGKTLIANDGTPL 1874
            ...|...||...|.:            ::.|:::..|      :.||.|.    |..:.::....
  Fly  1804 LFVLAAGSLIAGLGYMYYQYRQRGHTDLNINMHFQNP------LATLGGT----KAFLEHERAEA 1858

  Rat  1875 GVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIAS 1908
            ||||........:||.   :|..|.:...:..|:
  Fly  1859 GVGFTTETGTVSSRGS---NDTFTTTSATSSFAA 1889

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp2XP_038960355.1 LDLa 28..62 CDD:238060 15/33 (45%)
LDLa 67..103 CDD:238060 3/35 (9%)
LDLa 108..142 CDD:238060 9/33 (27%)
LDLa 148..179 CDD:238060 3/30 (10%)
LDLa 183..217 CDD:238060 15/35 (43%)
LDLa 222..256 CDD:238060 17/34 (50%)
LDLa 265..299 CDD:238060 13/35 (37%)
LY 460..500 CDD:214531 13/39 (33%)
LY 502..547 CDD:214531 18/44 (41%)
LY 550..590 CDD:214531 16/39 (41%)
LY 775..817 CDD:214531 16/41 (39%)
Ldl_recept_b 837..877 CDD:423042 8/51 (16%)
LY 863..903 CDD:214531 8/40 (20%)
LDLa 1025..1059 CDD:238060 14/33 (42%)
Ldl_recept_a 1065..1101 CDD:395011 18/35 (51%)
LDLa 1110..1144 CDD:238060 15/33 (45%)
LDLa 1150..1184 CDD:238060 16/34 (47%)
LDLa 1188..1223 CDD:238060 13/34 (38%)
LDLa 1231..1263 CDD:197566 11/32 (34%)
LDLa 1272..1306 CDD:238060 16/34 (47%)
LDLa 1313..1345 CDD:197566 11/45 (24%)
FXa_inhibition 1359..1394 CDD:405372 15/36 (42%)
EGF_CA 1396..1435 CDD:214542 13/38 (34%)
LY 1507..1549 CDD:214531 11/41 (27%)
LY 1551..1595 CDD:214531 11/60 (18%)
LY 1597..1638 CDD:214531 10/43 (23%)
FXa_inhibition 1715..1746 CDD:405372 11/30 (37%)
Ldl_recept_b 1889..1933 CDD:395012 4/20 (20%)
LY 1917..1959 CDD:214531
FXa_inhibition 2028..2064 CDD:405372
YncE 2115..>2307 CDD:225926
LY 2188..2231 CDD:214531
LY 2233..2273 CDD:214531
FXa_inhibition 2352..2388 CDD:405372
LY 2465..2506 CDD:214531
Ldl_recept_b 2525..2565 CDD:395012
LY 2551..2591 CDD:214531
LY <2600..2631 CDD:214531
FXa_inhibition 2661..2698 CDD:405372
LDLa 2705..2737 CDD:197566
LDLa 2747..2781 CDD:238060
exchanger_TraA <2748..3136 CDD:411343
LDLa 2912..2944 CDD:197566
LDLa 3000..3034 CDD:238060
LDLa 3039..3070 CDD:197566
LDLa 3082..3116 CDD:238060
cEGF 3139..3162 CDD:403760
EGF_CA 3159..3198 CDD:214542
LY 3226..3268 CDD:214531
LY 3269..3311 CDD:214531
Ldl_recept_b 3340..3380 CDD:395012
LY 3365..3406 CDD:214531
LY 3407..3448 CDD:214531
FXa_inhibition 3476..>3505 CDD:405372
LDLa 3519..3553 CDD:238060
LDLa 3560..3591 CDD:197566
LDLa 3600..3632 CDD:197566
LDLa 3641..3673 CDD:197566
LDLa 3689..3721 CDD:238060
LDLa 3728..3761 CDD:238060
LDLa 3766..3800 CDD:238060
LDLa 3805..3839 CDD:238060
LDLa 3849..3881 CDD:238060
LDLa 3892..3922 CDD:197566
LDLa 3935..3969 CDD:238060
EGF_CA 4014..4054 CDD:214542
LY 4148..4183 CDD:214531
Ldl_recept_b 4204..4244 CDD:395012
LY 4229..4271 CDD:214531
FXa_inhibition 4345..>4363 CDD:405372
ylNP_996433.1 LDLa 90..124 CDD:238060 15/33 (45%)
LDLa 131..166 CDD:238060 13/59 (22%)
LDLa 184..216 CDD:238060 13/31 (42%)
LDLa 227..262 CDD:238060 17/34 (50%)
LDLa 271..302 CDD:238060 11/30 (37%)
FXa_inhibition 352..387 CDD:291342 13/41 (32%)
Ldl_recept_b 442..482 CDD:278487 11/39 (28%)
LY 466..508 CDD:214531 13/41 (32%)
Ldl_recept_b 529..569 CDD:278487 17/42 (40%)
LY 553..595 CDD:214531 16/41 (39%)
LY 596..637 CDD:214531 13/42 (31%)
FXa_inhibition 669..700 CDD:291342 10/33 (30%)
LY 774..815 CDD:214531 16/40 (40%)
LDLa 1032..1062 CDD:238060 14/29 (48%)
LDLa 1074..1109 CDD:238060 18/34 (53%)
LDLa 1118..1152 CDD:238060 15/33 (45%)
LDLa 1157..1189 CDD:197566 14/31 (45%)
LDLa 1198..1232 CDD:238060 13/34 (38%)
LDLa 1243..1279 CDD:238060 13/36 (36%)
LDLa 1283..1318 CDD:238060 16/34 (47%)
LDLa 1340..1371 CDD:197566 8/30 (27%)
FXa_inhibition 1388..1416 CDD:291342 13/27 (48%)
EGF_CA 1418..1452 CDD:214542 12/33 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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