DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sptbn2 and Dys

DIOPT Version :9

Sequence 1:XP_008758314.1 Gene:Sptbn2 / 29211 RGDID:3751 Length:2395 Species:Rattus norvegicus
Sequence 2:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster


Alignment Length:2975 Identity:606/2975 - (20%)
Similarity:1053/2975 - (35%) Gaps:921/2975 - (30%)


- Green bases have known domain annotations that are detailed below.


  Rat    58 LQDEREAVQKKTFTKWVNSHLARVTCR-VGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIH 121
            |.|||:.:||||||||:||||....|. |.||:.|||||..||.||..|: :|..||.|||||:|
  Fly     6 LIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLT-QTNLKPEKGRMRVH 69

  Rat   122 CLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAK 186
            .:.|::|.:..:::..|.|.|:.|.|||.||.:|||||:|.|.|.|..|.:......|..:||  
  Fly    70 HINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVEKS-- 132

  Rat   187 DALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLA 251
              ||.|.:..|..: .:.:::|::||.||.||..|:..|..: |:.::..:.:|...|..||:||
  Fly   133 --LLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEE-LNLQAALQQHALKRLHLAFDLA 193

  Rat   252 EKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMK------------------------- 291
            .:...:.||||.|||:..:||.|||..||...||....|:                         
  Fly   194 HRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSIT 258

  Rat   292 ---------------------ALAVEGKRIGKVLDHAM-------EAEHLVEKYESLASELLQWI 328
                                 |.::|.:..|::..|:|       .|...:..|:|....:|   
  Fly   259 DLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAVL--- 320

  Rat   329 EQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQ----------SKL 383
               .:.|.|.||.:     || |.....::|.:.  :|.|..:..:.|...|          |.|
  Fly   321 ---TLLLEDEQLLS-----QN-LPDPQDFQTAKL--QFHENESFMLKLTEHQEYVGEALEEGSNL 374

  Rat   384 RANNQKVYTPREGRLISD------------INKAWE--RLEKAEHERELALRTELIRQEKLEQLA 434
            ...:||.     |..:|.            :|:.||  ||...:.:.::.:|....:::||||| 
  Fly   375 INESQKA-----GAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQL- 433

  Rat   435 ARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAEL- 498
                     |:...|...|:....:.|..|...|..:.:.:.::.|:   |.:.:.||::::.: 
  Fly   434 ---------RQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADL---SEQQELVDSLSSMVV 486

  Rat   499 ----AAEHYHDIK-RIAA---RQNNVARLWDFLRE-----------MVAARRERLLL-------- 536
                .:.:::|:: |::|   |.::|.: |..||:           .:.||.:.|.|        
  Fly   487 IVNDTSGNFNDLEDRLSALGERWSHVVK-WSDLRKEKLQQYKCISRWLDAREQDLKLMESRDVTD 550

  Rat   537 --------NLELQKVFQDLL----YLMDWMAEMKGRLQ-SQDLGK----HLAGVEDLLQ-LHELV 583
                    | ||....:|||    ||:|....:...|| ..|.|:    .|...||.|. |.::|
  Fly   551 VGGITQRIN-ELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIV 614

  Rat   584 EADIAVQAERV-----------------RAVSASA-------LRFCDPGKEYRPCDPQLVSER-- 622
            |    ||..|:                 |.|....       :||.:...:....:..|.|::  
  Fly   615 E----VQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRK 675

  Rat   623 --------------------VATLEQSYEAL--------CELAATRRARLEESRRL-----WRFL 654
                                |..:||..:.|        |||  .:..:.|.|||.     .:.|
  Fly   676 LRNADNFNALENHIMEHFGYVQEVEQKLQQLQRQSLRQQCEL--LKELQAENSRRCGTLPELKKL 738

  Rat   655 WEVGEAEAWVR----EQQHLLASAETGRDLTGVL--RLLNKHTALRGE-MSGRLGPLKLTLEQGQ 712
            :||.|.|...|    |:.|:....:...:|:..|  :....||.|..| ....|...||.|...:
  Fly   739 YEVCELEDPSRNLLLEETHIKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSR 803

  Rat   713 QLVAEGHPGANQASTRAAELQAQWERLEALAEERAQRLAQAA------SLYQFQADAN-DMEAW- 769
            ....: |.|    |....||:.:...:|:||.|.::  |:.|      :|.:::.|.. ..::| 
  Fly   804 DWYKQ-HAG----SASGNELEQRLSHMESLASEISE--AKTATEELDDNLIEWKQDFGLFYDSWH 861

  Rat   770 -LVDALRLVSSPEVGHDEFSTQALARQHRALEEEI------RAHRPTLDALREQAAALPPALSHT 827
             :..||:.:.....|      ::|:||.:.:::.:      :.....|:.::||...|...|...
  Fly   862 DMKQALQALIQQRGG------ESLSRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEM 920

  Rat   828 PEVQGRVPTLEQHY-------------EELQARAGERARALE-----AA--LAFYTMLSEAGACG 872
            ..::.....:.:|.             |:|..|..::..|:|     ||  .|...||..|.   
  Fly   921 ESLRLTYDNIPKHLIGEELQTAWNRLPEQLNERVIKQTTAIENLNHFAAEYNAIIAMLRSAA--- 982

  Rat   873 LWVEEKEQWLNGL--ALPERLEDLEVVQQRFETLEPEMNALAARVTAVSDIAEQLLKASPPGKDR 935
                  :..|||.  |..:.|..||:            :.::||     :.:|.|:|.:.|.:..
  Fly   983 ------DSKLNGSDGASSQDLRKLEI------------DVISAR-----NFSEILIKEAEPAQKE 1024

  Rat   936 IIGTQ-EQLNQRWQQFRSLADGKKAALTSALS-IQNYHLECTETQAWMRE--------------- 983
            .:.:| ..||..:.|...:...||...|...| |....|...||..|:.:               
  Fly  1025 SLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQLRLKETDQWLTDLESNTPKSGISDIVN 1089

  Rat   984 ---------------KTKVIESTQ--DLGNDLAGVLALQR-KLAGTERD---------LEAISAR 1021
                           :|...|:||  || |:..|.|.||. :|...:|:         ...|:||
  Fly  1090 SNELFQSKSRFQTLKETCERETTQFRDL-NERGGELLLQMDELQDQDRESRYGSLAKQFTRINAR 1153

  Rat  1022 VGELTQEANALAAGHPAQAPAINTRLGEV------QTGWED-LRATMRRREESLGEARRLQDFLR 1079
            ..|:|:    |.....|....|:|:|||.      :||:.| |...:|...|:..:|   ::.:.
  Fly  1154 WTEVTE----LVYAKTALLEHISTQLGEFKKFMVSETGYLDKLENKIRNTPENAADA---EEIME 1211

  Rat  1080 SLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSE--YSRLRTLGEEVTRDQ 1142
            .|||.:                                  .|.|:.||  ..:::.:|.|:..::
  Fly  1212 ELDDLE----------------------------------NVLRSHSEEWLDKIQEIGNELIDNE 1242

  Rat  1143 --ADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHT 1205
              ||.    :|:.::.....|.:|.:..:.|...|.|.      :.:|.|:|..:...|..|:..
  Fly  1243 FMADS----IRRDIDETVQRWTQLQQQAKKRTELLEQK------VSEAEQSEKCIVQFEKWLTRV 1297

  Rat  1206 EMPGTLQAADAAIKKLEDFMSTMD-------------ANGERIRGLLEAGRQLVSKGNI-HAEKI 1256
            :        |.....|::.::.:|             ||.:..:.:.|...:....|.: .|.::
  Fly  1298 D--------DILSDHLDNDVTIVDQPEEFQRLAHEFVANEKNFKEISELIDEHTRNGKVGAANRL 1354

  Rat  1257 QEKADSIEKRHRKNQEAVQQLLGRLRDNREQQHFLQDCQELKL---WID----EKMLTAQDVSYD 1314
            ||:.:.:|.|.:..|..:.:...           :|...|.:|   :.|    |:.....||:..
  Fly  1355 QEQLNLMEVRFKYCQAKLSKCTA-----------IQHSYESRLNRAYTDLRNVERSTEVVDVASA 1408

  Rat  1315 EARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEK----PELKVLVSEKLEDLHRRWDEL 1375
            ....:.|::||.......|:..|..::...|.||.:..::    |:   .:|::::.|...::.|
  Fly  1409 GPNTVQTQYQKCLQIYRTLSEIKSEIESTIKTGRRVCEDRYTKSPK---QLSQRIDALKHLYNTL 1470

  Rat  1376 -ETTTQAK---------ARSL---FDA--NRAELFA----------------------------- 1396
             |..||:|         ||.|   ||:  |....|.                             
  Fly  1471 GENVTQSKATLERLLTLARQLEECFDSADNLIRRFESPQEVHDRNSILLEFEDVLRRCEDHYNEY 1535

  Rat  1397 -----QSCSA-LESWLESLQAQLH---SDDYGKDLTSV--------NILLKKQQMLEREM----A 1440
                 |||.. ....::.|:|..|   |.|..|.||.:        ||.|:..:.:|.::    .
  Fly  1536 NKSCDQSCMVETRQRIDGLKATYHKLTSADIIKRLTEMKTTLQNLDNISLETLRAMEHDLKEINV 1600

  Rat  1441 VREKEVEAIQAQAKALAQEDQSAGEVERTSRAVEEKFRALCQPMKD--------------RCRRL 1491
            ....|:|.:|.|..|:..:.......|.|:.|.    |....|..|              |.|..
  Fly  1601 PSNPEIEKLQQQVIAIVVDVLKTRFNEATTLAA----RNTSSPDNDDTEIVVVSDTVRQRRARTP 1661

  Rat  1492 QASREQHQFHRDVEDEILWVTERLPMASSLEHGKD-LPSVQLLMKKNQTLQKEIQGHEPRIADL- 1554
            |:.......|....:......|..|.|...:...| ||.....:.::.||..:|..:..::.:. 
  Fly  1662 QSGESPSSAHTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVTNTP 1726

  Rat  1555 -KERQRTLGTAAAGPELAELQEMWKRLSHELELRGKRLE-EALRAQQFYRDAAEAEAWMGE---- 1613
             .:..:|...|.:.|            :..:|:|.|.:: :.:..|..     :.|...||    
  Fly  1727 PPKPAKTKRKAPSSP------------AQVVEIRVKNIQNDKMSVQNI-----DLEPQQGEIVDT 1774

  Rat  1614 ------------------QELHMMGQEKAKDELSAQAE-----VKKHQVLEQALADYAQTIKQLA 1655
                              |.:.:.....:...:.:|.:     ..||.:.|..|...:...:..|
  Fly  1775 VNILESVEPFVPEYVETVQIVDLSEDSDSSVRVDSQGKEMRRSKSKHSLNETPLPKVSDNDEDSA 1839

  Rat  1656 ASSQDMIDHEHPESTRLTIRQAQVDKLYAGL----KELAGER---RERLQEH------------- 1700
            ...:|::   .|.:...:....:|:|.....    |.:|.||   |:..:|.             
  Fly  1840 EQEEDLL---RPSAENTSTPFLRVEKRRISFDEKRKRVANERDILRDSEEEEPKTPDTPRAAQVS 1901

  Rat  1701 --LRLCQLRRELDDLEQWIQERE-VVAASHELGQDYEHVTMLRDK-FREFSRD-TSTIGQER--- 1757
              .|..||:.|:|.||.....|: ..:...|.|.|.|.:....|: ...||.: ||||..:.   
  Fly  1902 KPKRWRQLQPEMDALEPESPGRDSFYSPDKESGFDAEPLVFSDDEDIPRFSLEMTSTIDSDSDTS 1966

  Rat  1758 ------------------------VDSANALANGLIAG-------------GHAARATVAEWK-- 1783
                                    ||.:|......|:.             ...|:..:.:.|  
  Fly  1967 RIMTPSTKNPNPFLSKVLESLSSPVDDSNVTLKSPISEEQPQNLDDRVREFDKQAKQMIYKLKLT 2031

  Rat  1784 ----DSLNEAWADLLELL--DTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAA 1842
                :..:|:.|:.|.||  .....:::....|....||.:.:::|:..:.|.:.....|::..|
  Fly  2032 KAKIEQCHESEAEDLRLLIAPDAATLISQGDSLVLETHGRQGSISRLVMRTQIILREQFREVQQA 2096

  Rat  1843 EALQRRHCAYEHDIQALSTQVQQVQDDGLR-----LQKAYAGDKAEEIGRHMQAVAEAWAQLQ-- 1900
            .:......|....:.  |..::::...|||     ::|......:.::.:.|:.:.|....||  
  Fly  2097 RSKTSGSGAPAPPLD--SVNIEELVTKGLRRINVLIEKTVDLKSSTDLEKRMEDINERHDDLQVI 2159

  Rat  1901 ----GSSAARRQ---LLLDTTDKFRFFKAVRELMLWMDGINLQM----------DAQERPRDVSS 1948
                |.:|...:   |:::..:|.:     ..|:...|.|.|.:          :.:||| |.||
  Fly  2160 VSAIGKNAQMPKVTPLMMNEIEKTK-----NNLIAHADSIELSLTELRNGPRISNGKERP-DASS 2218

  Rat  1949 A-------------------------------DLVIKNQQGIKAEIEARADRFSACIDMGQEL-- 1980
            |                               |.:...|..||.:        |..:|.|..:  
  Fly  2219 AATMSCRSEYNNEPSGTGALAGSFDKSVLQISDWLTWEQNMIKIQ--------SVLVDDGDAVRL 2275

  Rat  1981 -LARNHYAAEEISEKLSQLQS------------RRQETAEKWQEK----------MDWLQLVLEV 2022
             :.:......|:..|..||..            :||:..||..::          :|:::..|:|
  Fly  2276 AIEKQEKVLRELKMKKPQLNELVHTAEVLKGDVKRQQLQEKELKQFSLAPHCSADLDYMRCCLKV 2340

  Rat  2023 LVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSA----LEKLT 2083
                  ..:.|.|                 ||....:.:..|..|:.::..:||.|    |||..
  Fly  2341 ------TRLREHW-----------------DETSQCVLQRAAQLKNMLSDSQRFEAKRLELEKWL 2382

  Rat  2084 A------------------LEERENEQKRKREEEERRKQ------PPTSEPMASQP--------- 2115
            |                  ||.::.|||....|..:.||      ..|.:.:|..|         
  Fly  2383 ARMEQRAERMGTIATTADILEAQQKEQKSFHAELHQNKQHFDIFNELTQKLIAVYPNDDTTRIKK 2447

  Rat  2116 -------------EGSLVDGQRV---------LDTAWDGTQSKLPPSTQAPSINGVCTDTESS-- 2156
                         .|.:..|:::         .|.|.|...:.|..:      ..:|.:.||.  
  Fly  2448 MTEVINQRYANLNSGVINRGKQLHAAVHSLQSFDRAMDQFLAFLSET------ETLCENAESDIE 2506

  Rat  2157 -QPLL---EQQRLEQSNVPEGPGSGTGDESSGPRGERQTLPRGPAPSPMPQSRSSE------SAH 2211
             .||:   .|..:|...|......|||.:..|....::       .:.|.|.|..|      :..
  Fly  2507 RNPLMFKDLQSEIETHRVVYDRLDGTGRKLLGSLTSQE-------DAVMLQRRLDEMNQRWNNLK 2564

  Rat  2212 VATLPARGAELSAQEQMEGTLCRKQEMEAFNKKAANRSWQNVYCVLRRGSLGFYKDARAASAGV- 2275
            ..::..|....|..|.....|...:|:         ..|     |:|       ||...::.|: 
  Fly  2565 SKSIAIRNRLESNSEHWNALLLSLREL---------TEW-----VIR-------KDTELSTLGLG 2608

  Rat  2276 PYHGEVPVSLAR-AQGSVAF--DYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATA 2337
            |..|:. |||.: .....||  ....::.:.:..|..|::|:   .:||.:|.          |:
  Fly  2609 PVRGDA-VSLQKQLDDHKAFRRQLEDKRPIVESNLTSGRQYI---ANEAAVSD----------TS 2659

  Rat  2338 SSASGEPEEPVVPSA---SRGLTRAM--TMPPVSQPEGSIVLRSKDGRER 2382
            .:.:....:....||   ||.|||::  .:..:|:...:::.||.:.:.|
  Fly  2660 DTEANHDSDSRYMSAEEQSRELTRSIRREVGKLSEQWNNLIDRSDNWKHR 2709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sptbn2XP_008758314.1 CH 68..166 CDD:214479 51/98 (52%)
CH 184..287 CDD:237981 37/102 (36%)
Spectrin 312..421 CDD:278843 26/132 (20%)
Spectrin 436..529 CDD:278843 18/112 (16%)
SPEC 541..753 CDD:238103 65/287 (23%)
SPEC 756..965 CDD:238103 46/240 (19%)
SPEC 968..1179 CDD:238103 53/263 (20%)
SPEC 1181..1390 CDD:238103 46/248 (19%)
SPEC 1391..1595 CDD:238103 46/271 (17%)
SPEC 1596..1808 CDD:238103 51/311 (16%)
SPEC 1809..2017 CDD:238103 48/287 (17%)
SPEC 2025..>2082 CDD:197544 11/60 (18%)
PH_beta_spectrin 2228..2331 CDD:269975 21/106 (20%)
PH 2249..2331 CDD:278594 19/85 (22%)
DysNP_001036722.1 CH 13..111 CDD:278723 52/98 (53%)
CH 129..225 CDD:278723 36/101 (36%)
SPEC 312..525 CDD:238103 50/245 (20%)
SbcC <325..957 CDD:223496 137/678 (20%)
Smc <816..1591 CDD:224117 171/882 (19%)
SPEC 1174..1365 CDD:238103 43/245 (18%)
SPEC 1289..1485 CDD:295325 38/217 (18%)
SPEC 2369..2576 CDD:238103 41/219 (19%)
SPEC 2477..2714 CDD:238103 56/281 (20%)
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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