Protein Alignment SLC25A5 and CG7943

DIOPT Version :10

• Sequence 1: NP_001143.2
• Gene: SLC25A5 / 292
• HGNCID: 10991
• Length: 298
• Species: Homo sapiens
• Sequence 2: NP_651766.1
• Gene: CG7943 / 43574
• FlyBaseID: FBgn0039741
• Length: 332
• Species: Drosophila melanogaster
• Alignment Length: 308
• Identity: 65/308 - (21%)
• Similarity: 116/308 - (37%)
• Gaps: 57/308 - (18%)

Human     7 SFAKDFLAGGVAAAISKTAVA-PIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSF 70
            ||..:..|.|..||....||. ||.:: :..|:.|.....:|..|.           :.:|:...
  Fly    51 SFQWEEFACGCGAAFVNIAVTYPIYKM-IFRQMLHGVPITSAFAQL-----------RHEGLGFL 103

Human    71 WRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWL--------YFAGNLASGGAAGATS 127
            :||.|..:.:  .|.:|:..|          ||...|:.:|        |.|..||:..|..|.|
  Fly   104 YRGMLPPLAQ--KTISLSIMF----------GVFDGTRRYLVEDYRLNDYGAKVLAAVVAGSAES 156

Human   128 LCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYF 192
            :  :.|.:..:|.||    .:...:.|....:....:....|.:.||:|.........:..|.:|
  Fly   157 I--LLPFERVQTLLA----DSKFHQHFSNTQNAFRYVVSHHGYRELYRGLEPVFWRNGLSNALFF 215

Human   193 GIYDTAKGMLPDPK--NTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTL 255
            .:.:.|...||..|  :|..|..::....:.|......||.:.::..:..:.|::.     .|:.
  Fly   216 VLREEASVRLPKRKSVSTRTVQEFIAGAVIGASISTIFYPLNVIKVSLQSEMGQRS-----EGSW 275

Human   256 DCWRKI--ARDEGGKAFFKGAWSNVLRGMGGAFVL-----VLYDEIKK 296
            ...::|  .||.....|::|...|.    |.:|:.     ..|:.:||
  Fly   276 QACKRIYVERDRRIGNFYRGCPFNT----GRSFISWGIMNTAYENLKK 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC25A5	NP_001143.2	Solcar 1	6..98		21/91 (23%)
		PTZ00169	7..296	CDD:240302	63/306 (21%)
		Solcar 2	111..201		20/97 (21%)
		Solcar 3	212..297		16/92 (17%)
		Important for transport activity. /evidence=ECO:0000250|UniProtKB:P12235	235..240		0/4 (0%)
		Nucleotide carrier signature motif. /evidence=ECO:0000250|UniProtKB:P02722	235..240		0/4 (0%)
CG7943	NP_651766.1	Mito_carr	54..136	CDD:395101	23/105 (22%)
		Mito_carr	141..229	CDD:395101	21/93 (23%)
		Mito_carr	235..322	CDD:395101	17/94 (18%)