Protein Alignment SLC25A5 and DPCoAC

DIOPT Version :10

• Sequence 1: NP_001143.2
• Gene: SLC25A5 / 292
• HGNCID: 10991
• Length: 298
• Species: Homo sapiens
• Sequence 2: NP_650891.1
• Gene: DPCoAC / 42429
• FlyBaseID: FBgn0067783
• Length: 365
• Species: Drosophila melanogaster
• Alignment Length: 299
• Identity: 96/299 - (32%)
• Similarity: 150/299 - (50%)
• Gaps: 36/299 - (12%)

Human    13 LAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNLAN 77
            ::|..|.|::||.:||::|.|:..|:::     .....::..:..:......:|||:.||||.|.
  Fly    77 ISGAAAGALAKTVIAPLDRTKINFQIRN-----DVPFSFRASLRYLQNTYANEGVLALWRGNSAT 136

Human    78 VIRYFPTQALNFAFKDKYKQIFLGGVDK---RTQFWLYFAGNLASGGAAGATSLCFVYPLDFART 139
            :.|..|..|:.|...:::::|.  .|||   .|:...:.||:|     ||.||....||||.||.
  Fly   137 MARIVPYAAIQFTAHEQWRRIL--HVDKDGTNTKGRRFLAGSL-----AGITSQSLTYPLDLARA 194

Human   140 RLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAK----G 200
            |:|......|    :|.|.....||:..:|.:.|::|:..:|.|:|.|....|..|:|.|    .
  Fly   195 RMAVTDRYTG----YRTLRQVFTKIWVEEGPRTLFRGYWATVLGVIPYAGTSFFTYETLKREYYE 255

Human   201 MLPDPK-NTHIVISWMIAQTVTAVAGLT-SYPFDTVRRRMM-MQSGRKGTDIMYTGTLDCWRKIA 262
            ::.:.| ||.:.:::..|   ...||.| |||.|.|||||. |:....|.| .|...|:...||.
  Fly   256 VVGNNKPNTLVSLAFGAA---AGAAGQTASYPLDIVRRRMQTMRVNTAGGD-RYPTILETLVKIY 316

Human   263 RDEGGK-AFFKGAWSNVLRG---MGGAFVLVLYDEIKKY 297
            |:||.| .|:||...|.::|   :|.:|  ..||.||.:
  Fly   317 REEGVKNGFYKGLSMNWIKGPIAVGISF--STYDLIKAW 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC25A5	NP_001143.2	Solcar 1	6..98		22/84 (26%)
		PTZ00169	7..296	CDD:240302	95/296 (32%)
		Solcar 2	111..201		31/93 (33%)
		Solcar 3	212..297		35/90 (39%)
		Important for transport activity. /evidence=ECO:0000250|UniProtKB:P12235	235..240		4/5 (80%)
		Nucleotide carrier signature motif. /evidence=ECO:0000250|UniProtKB:P02722	235..240		4/5 (80%)
DPCoAC	NP_650891.1	PTZ00169	77..336	CDD:240302	89/278 (32%)