Protein Alignment SLC25A5 and Shawn

DIOPT Version :10

• Sequence 1: NP_001143.2
• Gene: SLC25A5 / 292
• HGNCID: 10991
• Length: 298
• Species: Homo sapiens
• Sequence 2: NP_001027071.1
• Gene: Shawn / 3772641
• FlyBaseID: FBgn0031039
• Length: 387
• Species: Drosophila melanogaster
• Alignment Length: 333
• Identity: 60/333 - (18%)
• Similarity: 119/333 - (35%)
• Gaps: 95/333 - (28%)

Human    19 AAISKTAVAPIERVKLLLQVQHASKQITADK-----------------------------QYKGI 54
            |.::...:.|::.:|..||.|  .:.:.::|                             ::.|.
  Fly    50 AMVTACFMTPLDVIKTRLQAQ--QQALLSNKCFLYCNGLMDHICPCGPDTPNPAAAKPAPRFSGT 112

Human    55 IDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQ----------F 109
            ||..::|.:.:|:.|.|.|....:|...|:..:.|...:::|..|.....|.|:          .
  Fly   113 IDAFIKISRTEGIGSLWSGLSPTLISALPSTIIYFVAYEQFKARFTDIHYKYTRRPDTIAHDIPH 177

Human   110 WLYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLY 174
            .:.|...|.:|.:....::..|.|::..||::.:   :.....|..|   .:.::.:|.|:.||:
  Fly   178 PIPFLVPLLAGVSGRILAVTCVSPVELIRTKMQS---QRMTHAEMFG---TIRQVVQSQGVLGLW 236

Human   175 QGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHI------VISWMIAQTVTAVAGLTSYPFDT 233
            :|...::...:.:...|:..|:..|......:.|..      .||..:|.|:|.       |||.
  Fly   237 RGLPPTILRDVPFSGIYWTCYEYLKSSFGVVEPTFSFSFAAGAISGSVAATITT-------PFDV 294

Human   234 VRRRMMMQSGRK---------------------------GTDIMYTG--------TLDCWRKIAR 263
            |:....::.|.|                           |...:::|        ...|...|:.
  Fly   295 VKTHEQIEFGEKFIFSDNPPKQVATKSVAMRLASIYRMGGVPAIFSGLGPRLFKVAPACAIMISS 359

Human   264 DEGGKAFF 271
            .|.||:||
  Fly   360 FEYGKSFF 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC25A5	NP_001143.2	Solcar 1	6..98		19/107 (18%)
		PTZ00169	7..296	CDD:240302	60/333 (18%)
		Solcar 2	111..201		17/89 (19%)
		Solcar 3	212..297		20/95 (21%)
		Important for transport activity. /evidence=ECO:0000250|UniProtKB:P12235	235..240		0/4 (0%)
		Nucleotide carrier signature motif. /evidence=ECO:0000250|UniProtKB:P02722	235..240		0/4 (0%)
Shawn	NP_001027071.1	Mito_carr	39..159	CDD:395101	20/110 (18%)
		Mito_carr	178..265	CDD:395101	17/92 (18%)
		Mito_carr	268..371	CDD:395101	21/107 (20%)