Protein Alignment SLC25A5 and CG1628

DIOPT Version :10

• Sequence 1: NP_001143.2
• Gene: SLC25A5 / 292
• HGNCID: 10991
• Length: 298
• Species: Homo sapiens
• Sequence 2: NP_572639.2
• Gene: CG1628 / 31990
• FlyBaseID: FBgn0030218
• Length: 459
• Species: Drosophila melanogaster
• Alignment Length: 309
• Identity: 80/309 - (25%)
• Similarity: 135/309 - (43%)
• Gaps: 50/309 - (16%)

Human    11 DFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNL 75
            |||||.:..|.......|::.||:.||        |..:.|:|::||.:...::.|||   ||..
  Fly   172 DFLAGSLGGAAQVYVSQPLDTVKVKLQ--------TFPEAYRGMLDCFLSTYRKDGVL---RGLY 225

Human    76 A-NVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWL--YFAGNLAS--GGAAGATSLCF----V 131
            | :|...|...|.|......|     ||..|...|.:  ..||:|.:  ...||:.:.||    :
  Fly   226 AGSVPAVFANVAENSVLFAAY-----GGCQKFVAFCVGKETAGDLTTVQNACAGSLAACFSTLTL 285

Human   132 YPLDFARTRLAA-----DVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQG----FNVSVQGIIIY 187
            .|.:..:.:|.|     :..:....::.|........|::::||:|.|:|    |...:.|...
  Fly   286 CPTELIKCKLQALREMKNFVEPAHPQDIRTPWTLTRYIWRTEGIRGFYRGLSSTFLREMPGYFF- 349

Human   188 RAAYFGIYDTAKGML--PDPKNTHI-VISWMIAQTVTAVAGLTS-YPFDTVRRRMMMQSGRKGTD 248
               :||.|:..:.:|  .|.....| .:..|||..:..|...|| :|.|.::.|:.:::..:.
  Fly   350 ---FFGSYEGTRELLRRDDQSKDDIGPLRTMIAGAIGGVCLWTSTFPADVIKSRIQVKNLNES-- 409

Human   249 IMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGM-GGAFVLVLYDEIKK 296
             |:....|    |.|.||..|.::|...:|||.: ..|.:.|:|:..|:
  Fly   410 -MFAVGAD----IVRREGVLALYRGLLPSVLRTIPATATLFVVYEYTKR 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC25A5	NP_001143.2	Solcar 1	6..98		27/87 (31%)
		PTZ00169	7..296	CDD:240302	79/307 (26%)
		Solcar 2	111..201		22/106 (21%)
		Solcar 3	212..297		24/87 (28%)
		Important for transport activity. /evidence=ECO:0000250|UniProtKB:P12235	235..240		1/4 (25%)
		Nucleotide carrier signature motif. /evidence=ECO:0000250|UniProtKB:P02722	235..240		1/4 (25%)
CG1628	NP_572639.2	Mito_carr	170..252	CDD:395101	29/95 (31%)
		Mito_carr	263..364	CDD:395101	22/104 (21%)
		Mito_carr	369..456	CDD:395101	25/92 (27%)