DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cd36 and CG10345

DIOPT Version :9

Sequence 1:	NP_113749.2	Gene:	Cd36 / 29184	RGDID:	2301	Length:	472	Species:	Rattus norvegicus
Sequence 2:	NP_650563.2	Gene:	CG10345 / 42017	FlyBaseID:	FBgn0027562	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	454	Identity:	113/454 - (24%)
Similarity:	208/454 - (45%)	Gaps:	61/454 - (13%)

- Green bases have known domain annotations that are detailed below.

  Rat     5 RNCGLITGAVIGAVLAVFGGILMPVGDLLIEKTIKREVVLEEGTIAFKNWVKTGTTVYRQFWIFD 69
            ||..|:..|.:|..|..||.::: :.|.| :..:..::.|:.||:..:.|:.....||...::|:
  Fly    10 RNAKLLRSAALGMTLLFFGSLVI-ISDPL-QSILDTQLSLKPGTLLHRLWLLPPLDVYINVYMFN 72

  Rat    70 VQNPEE-VAKNSSKIKVKQRGPYTYRVRYLAKENITQDPKDSTVSFVQPNGAIFEPSLSVGTEN- 132
            ..|.:| .:..:||:::::.|||.|: ..|:..|:|.:..::|:::......:|.|..|||...
  Fly    73 YTNVDEFTSGRASKLQLQEVGPYVYK-EVLSNHNVTYNESNNTITYSPKREYVFAPERSVGDPKI 136

  Rat   133 -----DNFTVLNLAVAAAPHIYTNSFVQGVLNSLIKKSKSSMFQTRSLKELLWGYKDPFLSL--- 189
                 .|..::.:...|:.   .:.|....|:::.::..|......|:.:.:|||:|..:.|
  Fly   137 DRIRAPNIPLMGVTTLASS---LSMFAALGLSAITRQLNSQPMLEMSVHDYMWGYEDHLVELASR 198

  Rat   190 -VPYPIS-TTVGV----FYPYNNTVDGVYKVFN-----GKD-------NISKVAIIDTYKGKRNL 236
             ||..|. ::.|:    |...|.:     .|||     .||       :..:...:|:..|:|..
  Fly   199 FVPNWIDFSSFGIMEKLFREGNES-----NVFNMNLPEPKDKYGMRMTDAPRGYTVDSINGERGF 258

  Rat   237 SYWESYCDMINGT---------DAASFPPFVEKSRTLRFFSSDICRSIYAVFGSEVNLKGIPVYR 292
            ..|: |.:..|||         ||..||..::::.....:....||.:...|.......|:..:.
  Fly   259 KGWQ-YNEETNGTMCNRIWGSHDATLFPLDMDENDEFFLYRRTFCRRLPVKFNRTTTFNGLDAFE 322

  Rat   293 FVLPANAFASPLQNPDNHCFCTEKVISNNCTSYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPI 357
            ||:..::|.|.:.|.::.|:|.    :|.|...||.::..|....|:.|:.|||:||.|.:.||.
  Fly   323 FVMEPDSFDSEVDNANSSCYCK----NNRCLKKGVGNVSPCYYNIPLAITYPHFMHADPSLLEPF 383

  Rat   358 EGLNPNEDEHRTYLDVEPITGFTLQFAK-RLQVNILVKPA---RKIEALKNLKRPYIVPILWLN 417
            :||.||.....:...|:|..|..:|... |||.|.:|...   |.:...:|:    |:|:||::
  Fly   384 DGLQPNVSRFTSTFVVQPQLGAPMQGTHLRLQANQVVGKVNFNRMMTPFENM----ILPLLWVD 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cd36	NP_113749.2	CD36	14..463	CDD:395898	109/445 (24%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000250	93..120		5/26 (19%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000250\|UniProtKB:P16671	460..472
CG10345	NP_650563.2	CD36	21..488	CDD:279474	109/443 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920