DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cd36 and santa-maria

DIOPT Version :9

Sequence 1:	NP_113749.2	Gene:	Cd36 / 29184	RGDID:	2301	Length:	472	Species:	Rattus norvegicus
Sequence 2:	NP_609121.2	Gene:	santa-maria / 34024	FlyBaseID:	FBgn0025697	Length:	563	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	135/497 - (27%)
Similarity:	248/497 - (49%)	Gaps:	51/497 - (10%)

- Green bases have known domain annotations that are detailed below.

  Rat     2 GCDRNCGLITGAVIGAVLAVFGGILMPVGDLLIEKTIKREVVLEEGTIAFKNWVKTGTTVYRQFW 66
            |...|..||.| :.|..|.:||.:.......|.:..:.:|:.|...|..::||......:....:
  Fly    10 GQKSNRKLIIG-IFGFCLGLFGILCGMFWVDLFDWIMHKEMALAPDTRVYENWKSPPIDLSLDIY 73

  Rat    67 IFDVQNPEEVAKNSSKIKVKQRGPYTYRVRYLAKENITQDPKDSTVSFVQPNGAIFEPSLSVGTE 131
            :::..|||:....|:|..::|.|||.: :....|.:|...|::::|::.:.:...|:.:.|.|:.
  Fly    74 LYNWTNPEDFGNLSTKPILEQVGPYRF-IERPDKVDIHWHPENASVTYRRRSLFYFDAAGSNGSL 137

  Rat   132 NDNFTVLN-LAVAAAPHIYTNSFVQGVLNSLI----KKSKSSMFQTRSLKELLW-GYKDPFLSL- 189
            :|..|.|| :|::||.   |..:...|..||:    |...:.|...:|:.|||: ||.|..:.:
  Fly   138 DDEITTLNAVALSAAA---TAKYWPPVKRSLVDVGLKMYGAEMSVQKSIDELLFTGYNDAMIDVA 199

  Rat   190 -----------VPYPISTTVGVFYPYNNTVD--GVYKVFNGKDNISKVAIIDTYKGKRNLSYWES 241
                       ||:   ...|.||..|.:.|  ||:.||.|.|.::|:..:.::..:.|..:::|
  Fly   200 MAMPIFGDEVKVPF---DKFGWFYTRNGSADLTGVFNVFTGADQLAKLGQMHSWNYQENTGFFDS 261

  Rat   242 YCDMINGTDAASFPPFVEKSRTLRFFSSDICRSIYAVFGSEVNLKGIPVYRFVLPANAFASPLQN 306
            ||.|.||:.....|..::...::..|:.|:||:|...:...|:::|:..|:|.....:..:..|.
  Fly   262 YCGMTNGSAGEFQPQHLKPGDSVGLFTPDMCRTIPLDYVETVDIEGLEGYKFSGGPRSVDNGTQY 326

  Rat   307 PDNHCFCTEKVISNNCTSYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLNPNEDEHRTYL 371
            |:|.|||     ...|...||::|..|:.|.||::|.|||.:|.|...:.:|||:||:.:|..|:
  Fly   327 PENLCFC-----GGQCVPSGVMNISSCRFGSPVFMSYPHFFNADPYYPDQVEGLSPNQKDHEFYM 386

  Rat   372 DVEPITGFTLQFAKRLQVNILVKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFRNQVTG 436
            .|:|.||..|:.|.|.|||:||:|.:.|.....:.|.:. |::|..:...|..:.|:
  Fly   387 VVQPSTGIPLEVAARFQVNMLVEPIQGISLYTGIPRIFF-PLVWFEQKVRITPDMAD-------- 442

  Rat   437 KIKLLGLVEM---------VLLGVGVVMFVAFMISYCACRSK 469
            ::|:|.:|.:         :::|:.::.:....|...:||::
  Fly   443 QLKVLPIVMLSGHIFAGICLIVGITLLCWTPVQILLASCRNR 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cd36	NP_113749.2	CD36	14..463	CDD:395898	128/477 (27%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000250	93..120		4/26 (15%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000250\|UniProtKB:P16671	460..472		3/10 (30%)
santa-maria	NP_609121.2	CD36	23..474	CDD:279474	127/471 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920