DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cdh10 and CadN

DIOPT Version :9

Sequence 1:NP_001162102.1 Gene:Cdh10 / 29181 RGDID:619741 Length:788 Species:Rattus norvegicus
Sequence 2:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster


Alignment Length:597 Identity:173/597 - (28%)
Similarity:294/597 - (49%) Gaps:79/597 - (13%)


- Green bases have known domain annotations that are detailed below.


  Rat    30 PGLQQMTAESHVPRGDGKILHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILS 94
            |..::.|..:.:...|.:.|.::           :.:.|.:|        .|:|:.. ::.|.|:
  Fly  1516 PVFERPTYRTQITEEDDRNLPKR-----------VLQVTATD--------GDKDRPQ-NIVYFLT 1560

  Rat    95 GDG------AGTLFIIDEKTGDIHATRRIDREE-----KAFYTLRAQAINRRTLRPVEPESEFVI 148
            |.|      |.:.|.|:..||:|...:.:||::     :..:|:.||......|   ...::..:
  Fly  1561 GQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGL---VGYADVQV 1622

  Rat   149 KIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQ-------GQ 206
            .:.|||||.|.||:.:|..:|.|....|..|:.:||.|.|||:.|::||::|||.:       |.
  Fly  1623 NLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGS 1687

  Rat   207 PYFSVEPETGIIRTALPNMNRENKEQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQ 271
            |.|.:||:||:|:||:..::||....|.:.:.|.|    .|||.||.|.:|.:.|:||.||:|.:
  Fly  1688 PIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTASIRVKDINDMPPQFTK 1748

  Rat   272 NTIHLRVLESSPVGTAVGS---VKATDADTGKNAEVDYRIID--GDGTDMFDIITEKDTQEGIIT 331
            :.....|.|:.  |||:..   :..|..|..:..:..|::||  |.|.|.|.::...| ..|.:.
  Fly  1749 DEWFTEVDETD--GTALPEMPILTVTVHDEDETNKFQYKVIDNSGYGADKFTMVRNND-GTGSLK 1810

  Rat   332 VKKPLDYE-----NRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIEDV-DEPPVFSRSSYL 390
            :.:|||||     |...:.::|..:....|...|::.    .:.|.:.:.|: |..|.|.|::..
  Fly  1811 IVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVA----YSWVVVKLRDINDNKPHFERANVE 1871

  Rat   391 FEVHEDIEVGTIIGTVMARDPD-STSSPIRFTLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQW 454
            ..|.||.:|||.:....|.||| ...|.:.:::||.:|..|.|.|:. |||:...:.||||:...
  Fly  1872 VSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAINQ-NGSVTIQRSLDREVVPR 1935

  Rat   455 HNLTVIAAEINNPKETTRVSVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDD-- 517
            |.:.::|.:..:|.:|...::.|.:.|:|||||:|...|...:.|:..|.:::: |.|.|.||  
  Fly  1936 HQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPRKVVE-ILATDDDDRS 1999

  Rat   518 PLGGQKFFFSL-----AAVNPNFTVQD-----NEDNTARILTRKNGFNRHEISTYLLPVVISDND 572
            ...|..|.|.|     ..:..:|.|:.     |.|..| :::....|:|.:...|::|:||.|:.
  Fly  2000 KSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMA-VISSLRSFDREQQKEYMIPIVIKDHG 2063

  Rat   573 YPIQSSTGTLTI 584
            .|..:.|.|||:
  Fly  2064 SPAMTGTSTLTV 2075

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cdh10NP_001162102.1 CA 80..158 CDD:214520 23/88 (26%)
Cadherin_repeat 164..265 CDD:206637 41/107 (38%)
Cadherin_repeat 273..380 CDD:206637 27/117 (23%)
Cadherin_repeat 388..485 CDD:206637 31/97 (32%)
Cadherin_repeat 493..587 CDD:206637 29/104 (28%)
Cadherin_C 643..780 CDD:279398
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637
Cadherin_repeat 973..1074 CDD:206637
Cadherin_repeat 1083..1166 CDD:206637
Cadherin_repeat <1219..1298 CDD:206637
Cadherin_repeat 1310..1414 CDD:206637
Cadherin_repeat 1423..1514 CDD:206637
Cadherin_repeat 1522..1630 CDD:206637 26/130 (20%)
Cadherin_repeat 1638..1741 CDD:206637 40/106 (38%)
Cadherin_repeat 1762..1861 CDD:206637 23/103 (22%)
Cadherin_repeat 1871..1966 CDD:206637 31/95 (33%)
Cadherin_repeat 1974..2083 CDD:206637 29/104 (28%)
EGF 2350..2380 CDD:278437
LamG 2385..2570 CDD:238058
EGF_2 <2605..2631 CDD:285248
Laminin_G_2 2665..2800 CDD:280389
EGF_CA 2869..2907 CDD:238011
Cadherin_C 2952..3088 CDD:279398
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 130 1.000 Domainoid score I5067
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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